Schnichels Lab

Neuroprotection & Drug Delivery

José Hurst

First nameJosé
Present position and titleDr.rer.nat

Business address

Institute for Ophthalmic Research
University of Tübingen
Elfriede-Aulhorn-Strasse 7
D-72076 Tübingen,

Phone: +49 (0)7071 29 87883
Fax: +49 (0)7071 29 25241
E-mail: jose.hurst[at]

Academic Education

Year Degree University Field of study
10/2008 – 02/2013 PhD (Dr. rer. nat.) University of Tuebingen, Germany Experimental virology and oncology
10/2003 - 07/2008 Diploma of Human biology University of Greifswald, Germany Immunology, Virology and Biochemistry
02/2007 - 04/2007 Internship Burnet Institute for Medical Research and Public Health, Melbourne, Australia Influence of Ca+ release on Lentivirus particle formation

Professional Experience

Period Institution Position Discipline
03/2014 - present Schnichels Lab,
University Eye Hospital Tübingen
Postdoctoral Research Fellow Drug delivery, retinal degeneration models, Glaucoma
03/2013 - 02/2014 Thermo Fisher Scientific Inc. Key Account and Product Development Manager PCR and ELISA Development for viral diagnostics

Professional Activities and Functions

Academic Teaching and Services

Since 2016 Studienpatenprogramm für Humanmediziner (Mentoring)

Past and Current Funding

2017-2019 Entwicklung von Alternativmethoden zur Vermeidung von Tierversuchen des Landes Baden-Württemberg:
„Etablierung einer retinalen Ganglienzelllinie“
2017-2018 Ernst und Berta Grimmke Stiftung:
„Validierung von Kanamycin beladenen Nanopartikeln zur Behandlung von Augeninfektionen"


  • Association for Research in Vision and Ophthalmology (ARVO)

Selected Publications

  1. J. Hurst, K. Hofmann, M. Vitkute, S. Müller, M. Löscher,  K.U. Bartz-Schmidt, M. S. Spitzer, S. Schnichels&, K. Januschowski& Comparison of Different Cell Culture Media in the Model of the Isolated and Superfused Bovine Retina: Investigating the Limits of More Physiological Perfusion Solutions Curr Eye Res. 2017
  2. J. Hurst*, S. Kuehn*, A. Jashari, K. Ahrens, T. Tsai, I. Wunderlich, H. Burkhard Dick, S. Schnichels, S. Joachim A novel ex-vivo retina culture model for oxidative stress induced by H2O2 Altern Lab Anim. 2017 Mar;45(1):11-25.
  3. J. Hurst, S. Schnichels, M. Spitzer, K.U. Bartz-Schmidt, M. Farecki, P. Szurman, K. Januschowski  “Toxic effects of Acid violet-17 on different ocular cells” Curr Eye Res. 2017 Mar 30:1-6. doi: 10.1080/02713683.2017.1285942.
  4. S. Schnichels, N. Schneider, C. Hohenadl, J. Hurst, A. Schatz, K. Januschowski, MS. Spitzer Efficacy of two different thiol-modified crosslinked hyaluronate formulations as vitreous replacement compared to silicone oil in a model of retinal detachment. PLoS One. 2017 Mar 1;12(3):e0172895. doi: 10.1371/journal.pone.0172895
  5. S. Kuehn*, J. Hurst*, F. Rensinghoff, T. Tsai, S. Grauthoff, Y. Satgunarajah, H. B. Dick, S. Schnichels, S.C.  Joachim Degenerative effects of cobalt-chloride treatment on neurons and microglia in a porcine retina organ culture model Exp Eye Res 2017 Jan 12. pii: S0014-4835(17)30023-4.
  6. S. Kuehn*, J. Hurst*, A. Jashari, K. Ahrens, T.Tsai, I.M. Wunderlich, H. B. Dick, S.C. Joachim and S. Schnichels. The Novel Induction of Retinal Ganglion Cell Apoptosis in Porcine Organ Culture by NMDA — An Opportunity for the Replacement of Animals in Experiments.  Altern Lab Anim. 2016 Dec;44(6):557-568.
  7. D. Süsskind, J. Hurst, JM Rohrbach, S. Schnichels. Novel mouse model for primary uveal melanoma: a pilot study. Clin Exp Ophthalmol. 2016 Aug 9. doi: 10.1111/ceo.12814.
  8. M. Schultheiss, S. Schnichels, T. Hermann, J. Hurst, M. Feldkaemper, B. Arango-Gonzalez, M. Ueffing, KU. Bartz-Schmidt, G. Zeck & MS. Spitzer Hypothermia Protects and Prolongs the Tolerance Time of Retinal Ganglion Cells against Ischemia. PLoS One. 2016 Feb 5;11(2):e0148616. eCollection 2016.
  9.  S. Mariacher, M. Ebner, K. Januschowski, J. Hurst, S. Schnichels, P. Szurman. Investigation of a novel implantable suprachoroidal pressure transducer for telemetric intraocular pressure monitoring. Exp Eye Res. 2016 Oct;151:54-60. doi: 10.1016/j.exer.2016.07.016.
  10. K. Januschowski, S.Mueller, C. Krupp, MS. Spitzer, J. Hurst, M. Schultheiss, KU Bartz-Schmidt, P. Szurman, S. Schnichels Glutamate and hypoxia as a stress model for the isolated perfused vertebrate retina. J Vis Exp. 2015 Mar 22;(97). doi: 10.3791/52270
  11. J. Fertey, J Hurst, E. Straub, A. Schenker, T. Iftner, F. Stubenrauch "Growth inhibition of HeLa cells is a conserved feature of high-risk human papillomavirus E8^E2C proteins and can also be achieved by an artificial repressor protein." J Virol 85(6): 2918-2926 2011.
  12. J. Reiser, J. Hurst, M. Voges, P. Krauss, P. Münch, T. Iftner, F. Stubenrauch. "High-risk human papillomaviruses repress constitutive kappa interferon transcription via E6 to prevent pathogen recognition receptor and antiviral-gene expression." J Virol 85(21): 11372-11380 2011.
    S. Finke, H. Granzow, J. Hurst, R. Pollin, TC. Mettenleiter Intergenotypic replacement of lyssavirus matrix proteins demonstrates the role of lyssavirus M proteins in intracellular virus accumulation. J Virol. 2010 Feb;84(4):1816-27. doi: 10.1128/JVI.01665-09.