Schnichels Lab

Neuroprotection & Drug Delivery


  1. Ebner M, Mariacher S, Hurst J, Szurman P, Schnichels S, Spitzer MS, Januschowski K. Characterization of a Standardized Ex-vivo Porcine Model to Assess Short Term Intraocular Pressure Changes and Trabecular Meshwork Vitality After Pars Plana Vitrectomy with Different Silicone Oil and BSS Tamponades. Curr Eye Res. 2017 Apr 25:1-6. doi: 10.1080/02713683.2017.1297461. [Epub ahead of print] PubMed PMID: 28441060.
  2. Hurst J, Kuehn S, Jashari A, Tsai T, Bartz-Schmidt KU, Schnichels S, Joachim SC. A novel porcine ex vivo retina culture model for oxidative stress induced by H₂O₂. Altern Lab Anim. 2017 Mar;45(1):11-25. PubMed PMID: 28409994.
  3. Hurst J, Schnichels S, Spitzer MS, Bartz-Schmidt KU, Farecki ML, Szurman P, Januschowski K. Negative Effects of Acid Violet-17 and MBB Dual In Vitro on Different Ocular Cell Lines. Curr Eye Res. 2017 Mar 30:1-6. doi: 10.1080/02713683.2017.1285942. [Epub ahead of print] PubMed PMID: 28358247.
  4. Schnichels S, Schneider N, Hohenadl C, Hurst J, Schatz A, Januschowski K, Spitzer MS. Efficacy of two different thiol-modified crosslinked hyaluronate formulations as vitreous replacement compared to silicone oil in a model of retinal detachment. PLoS One. 2017 Mar 1;12(3):e0172895. doi: 10.1371/journal.pone.0172895. eCollection 2017. PubMed PMID: 28248989; PubMed Central PMCID: PMC5332068.
  5. Kuehn S, Hurst J, Jashari A, Ahrens K, Tsai T, Wunderlich IM, Dick HB, Joachim SC, Schnichels S. The novel induction of retinal ganglion cell apoptosis in porcine organ culture by NMDA - an opportunity for the replacement of animals in experiments. Altern Lab Anim. 2016 Dec;44(6):557-568. PubMed PMID: 28094536.
  6. Kuehn S, Hurst J, Rensinghoff F, Tsai T, Grauthoff S, Satgunarajah Y, Dick HB, Schnichels S, Joachim SC. Degenerative effects of cobalt-chloride treatment on neurons and microglia in a porcine retina organ culture model. Exp Eye Res. 2017 Feb;155:107-120. doi: 10.1016/j.exer.2017.01.003. Epub 2017 Jan 12. PubMed PMID: 28089775.
  7. Schultheiss M, Schnichels S, Konrad EM, Bartz-Schmidt KU, Zahn G, Caldirola P, Fsadni MG, Caram-Lelham N, Spitzer MS. α5β1-Integrin inhibitor (CLT-28643) effective in rabbit trabeculectomy model. Acta Ophthalmol. 2017 Feb;95(1):e1-e9. doi: 10.1111/aos.13215. Epub 2016 Aug 31. PubMed PMID: 27576860.
  8. Süsskind D, Hurst J, Rohrbach JM, Schnichels S. Novel mouse model for primary uveal melanoma: a pilot study. Clin Exp Ophthalmol. 2017 Mar;45(2):192-200. doi: 10.1111/ceo.12814. Epub 2016 Sep 7. PubMed PMID: 27505446.
  9. Mariacher S, Ebner M, Januschowski K, Hurst J, Schnichels S, Szurman P. Investigation of a novel implantable suprachoroidal pressure transducer for telemetric intraocular pressure monitoring. Exp Eye Res. 2016 Oct;151:54-60. doi: 10.1016/j.exer.2016.07.016. Epub 2016 Jul 25. PubMed PMID: 27456134.
  10. Schnichels S, Dorfi T, Schultheiss M, Arango-Gonzalez B, Bartz-Schmidt KU, Januschowski K, Spitzer MS, Ziemssen F. Ex-vivo-examination of ultrastructural changes in organotypic retina culture using near-infrared imaging and optical coherence tomography. Exp Eye Res. 2016 Jun;147:31-6. doi: 10.1016/j.exer.2016.04.011. Epub 2016 Apr 21. PubMed PMID: 27109031.
  11. Süsskind D, Hagemann U, Schrader M, Januschowski K, Schnichels S, Aisenbrey S. Toxic effects of melphalan, topotecan and carboplatin on retinal pigment epithelial cells. Acta Ophthalmol. 2016 Aug;94(5):471-8. doi: 10.1111/aos.12990. Epub 2016 Feb 19. PubMed PMID: 26893290.
  12. Schultheiss M, Schnichels S, Hermann T, Hurst J, Feldkaemper M, Arango-Gonzalez B, Ueffing M, Bartz-Schmidt KU, Zeck G, Spitzer MS. Hypothermia Protects and Prolongs the Tolerance Time of Retinal Ganglion Cells against Ischemia. PLoS One. 2016 Feb 5;11(2):e0148616. doi: 10.1371/journal.pone.0148616. eCollection 2016. PubMed PMID: 26848953; PubMed Central PMCID: PMC4744055.
  13. Januschowski K, Krupp C, Mueller S, Hofmann K, Schnichels S, Hagemann U, Spitzer MS, Bartz-Schmidt KU, Aisenbrey S. Investigating short-term toxicity of melphalan in a model of an isolated and superfused bovine retina. Graefes Arch Clin Exp Ophthalmol. 2016 Jan;254(1):91-6. doi: 10.1007/s00417-015-3149-1. Epub 2015 Sep 3. PubMed PMID: 26335534.
  14. Januschowski K, Müller S, Krupp C, Spitzer MS, Hurst J, Schultheiss M, Bartz-Schmidt KU, Szurman P, Schnichels S. Glutamate and hypoxia as a stress model for the isolated perfused vertebrate retina. J Vis Exp. 2015 Mar 22;(97). doi: 10.3791/52270. PubMed PMID: 25868118; PubMed Central PMCID: PMC4401365.
  15. Januschowski K, Mueller S, Dollinger R, Schnichels S, Hofmann J, Spitzer MS, Bartz-Schmidt KU, Szurman P, Thaler S. Investigating retinal toxicity of tempol in a model of isolated and perfused bovine retina. Graefes Arch Clin Exp Ophthalmol. 2014 Jun;252(6):935-41. doi: 10.1007/s00417-014-2632-4. Epub 2014 May 2. PubMed PMID: 24789463.
  16. Schultheiss M, Schnichels S, Mlynczak T, Dipl-Ing JH, Bartz-Schmidt KU, Szurman P, Spitzer MS. Cyclosporine a protects RGC-5 cells from excitotoxic cell death. J Glaucoma. 2014 Apr-May;23(4):219-24. doi: 10.1097/IJG.0000000000000040. PubMed PMID: 24633087.
  17. Januschowski K, Schnichels S, Hagemann U, Koch V, Hofmann J, Spitzer MS, Bartz-Schmidt KU, Szurman P, Lüke M, Aisenbrey S. Electrophysiological toxicity testing of VEGF Trap-Eye in an isolated perfused vertebrate retina organ culture model. Acta Ophthalmol. 2014 Jun;92(4):e305-11. doi: 10.1111/aos.12300. Epub 2013 Nov 8. PubMed PMID: 24206925.
  18. Schnichels S, Hagemann U, Januschowski K, Hofmann J, Bartz-Schmidt KU, Szurman P, Spitzer MS, Aisenbrey S. Comparative toxicity and proliferation testing of aflibercept, bevacizumab and ranibizumab on different ocular cells. Br J Ophthalmol. 2013 Jul;97(7):917-23. doi: 10.1136/bjophthalmol-2013-303130. Epub 2013 May 17. PubMed PMID: 23686000.
  19. Schultheiss M, Januschowski K, Ruschenburg H, Schramm C, Schnichels S, Szurman P, Bartz-Schmidt KU, Spitzer MS. Dulbecco's Modified Eagle Medium is neuroprotective when compared to standard vitrectomy irrigation solution. Graefes Arch Clin Exp Ophthalmol. 2013 Jun;251(6):1613-9. doi: 10.1007/s00417-012-2255-6. Epub 2013 Jan 11. PubMed PMID: 23306786.
  20. Spitzer MS, Sat M, Schramm C, Schnichels S, Schultheiss M, Yoeruek E, Dzhelebov D, Szurman P. Biocompatibility and antifibrotic effect of UV-cross-linked hyaluronate as a release-system for tranilast after trabeculectomy in a rabbit model--a pilot study. Curr Eye Res. 2012 Jun;37(6):463-70. doi: 10.3109/02713683.2012.658593. PubMed PMID: 22577763.
  21. Januschowski K, Zhour A, Lee A, Maddani R, Mueller S, Spitzer MS, Schnichels S, Schultheiss M, Doycheva D, Bartz-Schmidt KU, Szurman P. Testing the biocompatibility of a glutathione-containing intra-ocular irrigation solution by using an isolated perfused bovine retina organ culture model - an alternative to animal testing. Altern Lab Anim. 2012 Mar;40(1):23-32. PubMed PMID: 22558975.
  22. Schnichels S, Schultheiss M, Hofmann J, Szurman P, Bartz-Schmidt KU, Spitzer MS. Trichostatin A induces cell death at the concentration recommended to differentiate the RGC-5 cell line. Neurochem Int. 2012 May;60(6):581-91. doi: 10.1016/j.neuint.2012.02.017. Epub 2012 Feb 25. PubMed PMID: 22391323.
  23. Schultheiss M, Ruschenburg H, Warga M, Schramm C, Januschowski K, Schnichels S, Biedermann T, Szurman P, Spitzer MS. Neuroprotective effects of a taurine-containing irrigation solution for vitrectomy. Retina. 2012 Jul;32(7):1343-9. doi: 10.1097/IAE.0b013e318232c37c. PubMed PMID: 22322280.
  24. Schultheiss M, Schnichels S, Miteva K, Warstat K, Szurman P, Spitzer MS, Van Linthout S. Staurosporine-induced differentiation of the RGC-5 cell line leads to apoptosis and cell death at the lowest differentiating concentration. Graefes Arch Clin Exp Ophthalmol. 2012 Aug;250(8):1221-9. doi: 10.1007/s00417-011-1906-3. Epub 2012 Jan 6. PubMed PMID: 22222923.
  25. Schnichels S, Heiduschka P, Julien S. RGMA and neogenin protein expression are influenced by lens injury following optic nerve crush in the rat retina. Graefes Arch Clin Exp Ophthalmol. 2012 Jan;250(1):39-50. doi: 10.1007/s00417-011-1791-9. Epub 2011 Sep 2. PubMed PMID: 21887516.
  26. Suesskind D, Schatz A, Schnichels S, Coupland SE, Lake SL, Wissinger B, Bartz-Schmidt KU, Henke-Fahle S. GDF-15: a novel serum marker for metastases in uveal melanoma patients. Graefes Arch Clin Exp Ophthalmol. 2012 Jun;250(6):887-95. doi: 10.1007/s00417-011-1786-6. Epub 2011 Sep 1. PubMed PMID: 21881845.
  27. Gaub P, Joshi Y, Wuttke A, Naumann U, Schnichels S, Heiduschka P, Di Giovanni S. The histone acetyltransferase p300 promotes intrinsic axonal regeneration. Brain. 2011 Jul;134(Pt 7):2134-48. doi: 10.1093/brain/awr142. PubMed PMID: 21705428.
  28. Schnichels S, Heiduschka P, Julien S. Different spatial and temporal protein expressions of repulsive guidance molecule a and neogenin in the rat optic nerve after optic nerve crush with and without lens injury. J Neurosci Res. 2011 Apr;89(4):490-505. doi: 10.1002/jnr.22584. Epub 2011 Feb 2. PubMed PMID: 21290411.
  29. Heiduschka P, Julien S, Schuettauf F, Schnichels S. Loss of retinal function in aged DBA/2J mice - New insights into retinal neurodegeneration. Exp Eye Res. 2010 Nov;91(5):779-83. doi: 10.1016/j.exer.2010.09.001. Epub 2010 Sep 9. PubMed PMID: 20832401.
  30. Heiduschka P, Schnichels S, Fuhrmann N, Hofmeister S, Schraermeyer U, Wissinger B, Alavi MV. Electrophysiological and histologic assessment of retinal ganglion cell fate in a mouse model for OPA1-associated autosomal dominant optic atrophy. Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1424-31. doi: 10.1167/iovs.09-3606. Epub 2009 Oct 15. PubMed PMID: 19834041.
  31. Schraermeyer M, Schnichels S, Julien S, Heiduschka P, Bartz-Schmidt KU, Schraermeyer U. Ultrastructural analysis of the pigment dispersion syndrome in DBA/2J mice. Graefes Arch Clin Exp Ophthalmol. 2009 Nov;247(11):1493-504. doi: 10.1007/s00417-009-1146-y. Epub 2009 Jul 30. PubMed PMID: 19641932.
  32. Julien S, Kreppel F, Beck S, Heiduschka P, Brito V, Schnichels S, Kochanek S, Schraermeyer U. A reproducible and quantifiable model of choroidal neovascularization induced by VEGF A165 after subretinal adenoviral gene transfer in the rabbit. Mol Vis. 2008 Jul 30;14:1358-72. PubMed PMID: 18682809; PubMed Central PMCID: PMC2493026.
  33. Schnichels S, Conrad S, Warstat K, Henke-Fahle S, Skutella T, Schraermeyer U, Julien S. Gene expression of the repulsive guidance molecules/neogenin in the developing and mature mouse visual system: C57BL/6J vs. the glaucoma model DBA/2J. Gene Expr Patterns. 2007 Dec;8(1):1-11. Epub 2007 Sep 18. PubMed PMID: 17942375.
  34. Julien S, Schnichels S, Teng H, Tassew N, Henke-Fahle S, Mueller BK, Monnier PP. Purkinje cell survival in organotypic cultures: implication of Rho and its downstream effector ROCK. J Neurosci Res. 2008 Feb 15;86(3):531-6. PubMed PMID: 17893923.