Euler Lab

Ophthalmic Research

Home » Labs » Euler Lab » Projects » Synapse development

Synapse development

Synapse development

Reciprocal synapses represent a very common synapse type in the CNS. Typically for these synapses, neurotransmission is bidirectional: In the mouse retina, rod bipolar cells release glutamate onto A17 amacrine cells which, in turn, provide GABAergic feedback and control the release from the bipolar cell axon terminals. We examined the role of  neurotransmission on the formation and the maintenance of this synapse. Surprisingly, we found that while perturbing GABAergic or glutamatergic transmission does not prevent initial synaptogenesis, GABAergic activity is necessary for the maintenance of axonal GABA receptors and the adjustment of glutamate release during development.

Involved Scientists:Timm Schubert, in collaboration with R.O. Wong (UW)
Funding Agency:Funded by the DFG (CIN-EXC 307).