Paquet-Durand Lab

Cell Death Mechanisms

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Current Research Projects

The following topics are currently being investigated:

  1. Enzymatic activities of calpains, poly-ADP-ribose polymerase (PARP) and poly-ADP-glycohydrolase (PARG), as well as Histone DeACetylases (HDAC) in retinal function and disease.
  2. The relations between rod and cone photoreceptor cell death and a comparison of relevant pathophysiological mechanisms.
  3. cGMP metabolism and the use of cGMP analogues to prevent RD.
  4. Use of organotypic retinal explant cultures as a model for diabetic retinopathy.
  5. Evaluation of drug delivery systems for ocular drug applications.