Paquet-Durand Lab

Cell Death Mechanisms

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Selected Publications

  1. Power M, Das S, Schütze K, Marigo V, Ekström P, Paquet-Durand F. Cellular mechanisms of hereditary photoreceptor degeneration - Focus on cGMP.Prog Retin Eye Res. 74:100772, 2020.
  2. Himawan E, Ekström P, Buzgo M, Gaillard P, Stefánsson E, Marigo V, Loftsson T, Paquet-Durand F. Drug delivery to retinal photoreceptors. Drug Discov. Today, 24(8):1637-1643, 2019.
  3. Vighi E, Trifunović D, Veiga-Crespo P, Rentsch A, Hoffmann D, Sahaboglu A, Strasser T, Kulkarni M, Bertolotti E, van den Heuvel A, Peters T, Reijerkerk A, Euler T, Ueffing M, Schwede F, Genieser H-G, Gaillard P, Marigo V, Ekström P, Paquet-Durand F. A novel combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration. Proc Natl Acad Sci U S A, 115:E2997-E3006, 2018.
  4. Kulkarni M, Trifunović D, Schubert T, Euler T, Paquet-Durand F. Calcium dynamics change in degenerating cone photoreceptors. Hum Mol Genet. 25:3729-3740, 2016.
  5. Sothilingam V, Garcia-Garrido M, Jiao K, Buena-Atienza E, Sahaboglu A, Trifunović D, Balendran S, Koepfli T, Mühlfriedel R, Schön C, Biel M, Heckmann A, Beck SC, Michalakis S, Wissinger B, Seeliger MW, Paquet-Durand F. Retinitis Pigmentosa: Impact of different Pde6a point mutations on the disease phenotype. Hum Mol Genet. 24:5486-99, 2015.
  6. Arango-Gonzalez B, Trifunović D, Sahaboglu A, Kranz K, Michalakis S, Farinelli P, Koch S, Koch F, Cottet S, Janssen-Bienhold U, Dedek K, Biel M, Zrenner E, Euler T, Ekström P, Ueffing M, Paquet-Durand F. Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration. PLoS One, 9:e112142, 2014.
  7. Jaumann M, Dettling J, Gubelt M, Zimmermann U, Gerling A, Paquet-Durand F, Feil S, Wolpert S, Franz C, Varakina K, Xiong H, Brandt N, Kuhn S, Geisler HS, Rohbock K, Ruth P, Schlossmann J, Hütter J, Sandner P, Feil R, Engel J, Knipper M, Rüttiger L: cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. Nature Med, 18:252-9, 2012.
  8. Paquet-Durand F, Beck S, Michalakis S, Goldmann T, Huber G, Mühlfriedel R, Trifunovic D, Fischer MD, Fahl E, Duetsch G, Becirovic E, Wolfrum U, van Veen T, Biel M, Tanimoto N, Seeliger MW: A key role for cyclic–nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa. Hum Mol Gen, 20:941-7, 2011.
  9. Paquet-Durand F, Hauck SM, van Veen T, Ueffing M, Ekström P: PKG activity causes photoreceptor cell death in two Retinitis Pigmentosa models. J Neurochem, 108:796-810, 2009.
  10. Paquet-Durand F, Silva J, Talukdar T, Johnson L, Azadi S, Hauck S, Ueffing M, van Veen T, Ekström P: Excessive activation of poly (ADP-ribose) polymerase (PARP) contributes to inherited photoreceptor degeneration in the rd1 mouse. J Neurosci, 27:10311-10319, 2007.