The retina is a thin layered nervous tissue in the back of the eye (left). Retinal cross section (right): Bipolar cells (coloured) connect the outer (top) with the inner retina (bottom) and represent a layer that lacks direct counterparts in other vertebrate sensory systems
figure 1

All visual information is broadcasted by an intra-retinal pathway formed by a group of neurons called bipolar cells. They collect photoreceptor signals in the outer retina and relay the signals to the inner retinal neurons. This transfer of visual information is far from passive: Each of the at least 10 bipolar cell types transforms the photoreceptor signals in a unique and highly specific way. As a result, the bipolar cell output signals form the first “elementary operations” from which the neural circuits of the inner retina compose a feature-oriented description of the visual world (for review, see Euler et al., 2014).

Schematics showing the individual projects of the Early Stage Researchers (ESRs), orga¬nized in three Work Packages (WP): WP1, Circuit & Function; WP2, Degeneration & Remodelling; WP3, Models & Technology. (MEA, multi-electrode array)
figure 2

Reflecting the partitioning of visual information into parallel channels, the retinal layer in which bipolar cell axon terminals meet their synaptic partners, is highly organized: This so-called “inner plexiform layer” effectively serves as the retina’s “switch board”: The input is provided by the different bipolar cell “channels”, while the output is carried by an even larger number of channels, represented by ganglion cells that form the optic nerve. Each of the ~20 ganglion cell types composes its feature-extracting circuits from a specific set of bipolar cell input it receives. Owing to its regular structure and ease of experimental access, the retina is amongst the best understood self-standing neuronal networks in neuroscience. Indeed, recent advances hold the exciting promise that an in-depth understanding of the bipolar cells – an entire class of neurons – and their role in the first critical steps of visual processing is within reach.

Our network trains young researchers in world-leading research labs towards completing this goal. We will accomplish this by exposing the students to a host of cutting-edge techniques and a broad spectrum of research approaches within the training network – from imaging at synaptic resolution, genetic models and retina degeneration to the application of retinal circuit principles for signal processing in artificial vision chips.

Euler T, Haverkamp S, Schubert T, Baden T (2014) Retinal bipolar cells: elementary building blocks of vision. Nat Rev Neurosci. 2014 Aug;15(8):507-19. http://www.ncbi.nlm.nih.gov/pubmed/?term=euler+baden+2014