Business address

Section of Neurobiology of the Eye
Institute for Ophthalmic Research
Centre for Ophthalmology,
University of Tübingen
Elfriede-Aulhorn-Strasse 7
D-72076 Tübingen,
Germany

Phone: +49 (0)7071 29-80739
Fax: +49 (0)7071 29-5196
E-mail: frank.schaeffel[at]uni-tuebingen.de

Since 1988 Reviewer for scientific journals: Nature Medicine, Science, Journal of Physiology, Vision Research, European Journal of Neuroscience, Journal of Neuroscience, Journal of the Optical Society of America, Visual Neuroscience, Experimental Eye Research, Ophthalmological and Physiological Optics, Graefe´s Archive for Clinical and Experimental Ophthalmology, Clinical Vision Science, Canadian Journal of Zoology, Investigative Opthalmology and Visual Science, Journal of Comparative Physiology, Ophthalmic Research, Optometry and Visual Science, Neurochemistry International, Strabismus, Journal of cataract and refractive surgery and others

From 1994 until now, 22 PhD students (Marieluise Bartmann, Hartmut Schwahn, Sigrid Diether, Sibylle Ohngemach, Matthias Ott, Anne Seidemann, Michaela Bitzer, Daniel Hartmann, Perikles Simon, Christine Brand, Beatrix Kovacs, Christine Schmucker, Ruth Schippert, Arne Ohlendorf, Alexandra Penha, Tudor Tepelus, Weizhong Lan, Yun Chen, Klaus Graef, Felix Maier, Barbara Świątczak, Andrea Carillo Alleman) have completed under my supervision and 2 are currently supervised (Sandra Gisbert, Daria Ivanchenko).

In addition, 3 MD student have finished (Florian Gekeler, Hakan Kaymak, Silke Thomas). About 15 students have completed their Diploma thesis in Biology.

More than 150 original research articles were published from 1985 until now (mostly on myopia), four patents, and more 5 Million Euros of extramural grants were attracted (German Research Council and German Ministery of Science and Technology (BMBF)).

In addition, three multicenter grants from the European Community, a Madam Curie Research Training Network (RTN) on Myopia (see archived website my-europia.net) with a volume of 3.2 Million Euros, an Initial Training Network (ITN) on optical and adaptational limits of vision (see archived website itn-opal.eu) with a volume of 2.8 Million Euros and a European Training Network (ETN) on the fundamental understanding of Myopia www.itn-myfun.eu with a volume of 3.5 Million Euro were attracted.

Invited presentations

Over 250 invited national and international presentations outside Tübingen from 1990-2019

Citations and h-index

Citations and h-index of Frank Schaeffel on Google Scholars

1. Mathis U, Feldkaemper M, Wang M, Schaeffel F. Studies on retinal mechanisms possibly related to myopia inhibition by atropine in the chicken.  Graefes Arch Clin Exp Ophthalmol. 2020 Feb;258(2):319-333. doi: 10.1007/s00417-019-04573-y. PMID: 31879820
2. Sanz Diez P, Schaeffel F, Wahl S, Ohlendorf A. Accommodation responses following contrast adaptation. Vision Res. 2020 May;170:12-17. doi: 10.1016/j.visres.2020.03.003. Epub 2020 Mar 24.  PMID: 32217367 Free article.
3. Wagner S, Schaeffel F, Troilo D. Changing accommodation behaviour during multifocal soft contact lens wear using auditory biofeedback training.  Sci Rep. 2020 Mar 19;10(1):5018. doi: 10.1038/s41598-020-61904-4. PMID: 32193512 Free PMC article.
4. Liu H, Schaeffel F, Trier K, Feldkaemper M. Effects of 7-Methylxanthine on Deprivation Myopia and Retinal Dopamine Release in Chickens. Ophthalmic Res. 2019 Sep 18:1-11. doi: 10.1159/000502529.
5. Wagner S, Schaeffel F, Zrenner E, Straßer T. Response to comment on 'Prolonged nearwork affects the ciliary muscle morphology' by Schachar & Schachar. Exp Eye Res. 2019 Oct;187:107786. doi: 10.1016/j.exer.2019.107786.
6. Swiatczak B, Feldkaemper M, Schraermeyer U, Schaeffel F. Demyelination and shrinkage of axons in the retinal nerve fiber layer in chickens developing deprivation myopia. Exp Eye Res. 2019 Nov;188:107783. doi: 10.1016/j.exer.2019.107783.
7. Sanz Diez P, Ohlendorf A, Schaeffel F, Wahl S. Effect of spatial filtering on accommodation. Vision Res. 2019 Nov;164:62-68. doi: 10.1016/j.visres.2019.07.005.
8. Wagner S, Schaeffel F, Zrenner E, Straßer T. Prolonged nearwork affects the ciliary muscle morphology. Exp Eye Res. 2019 Sep;186:107741. doi: 10.1016/j.exer.2019.107741. Epub 2019 Jul 20.
9. Wang M, Aleman AC, Schaeffel F. Probing the Potency of Artificial Dynamic ON or OFF Stimuli to Inhibit Myopia Development. Invest Ophthalmol Vis Sci. 2019 Jun 3;60(7):2599-2611. doi: 10.1167/iovs.18-26471.
10. Swiatczak B, Feldkaemper M, Schaeffel F. Changes in fundus reflectivity during myopia development in chickens. Biomed Opt Express. 2019 Mar 13;10(4):1822-1840. doi: 10.1364/BOE.10.001822.
11. Schaeffel F. [Prevention of myopia]. Ophthalmologe. 2019 Jun;116(6):509-517. doi: 10.1007/s00347-019-0892-4. Review. German.
12. Wang M, Schaeffel F, Jiang B, Feldkaemper M. Effects of Light of Different Spectral Composition on Refractive Development and Retinal Dopamine in Chicks. Invest Ophthalmol Vis Sci. 2018 Sep 4;59(11):4413-4424. doi: 10.1167/iovs.18-23880.
13. Kaymak H, Fricke A, Mauritz Y, Löwinger A, Klabe K, Breyer D, Lagenbucher A, Seitz B, Schaeffel F. Short-term effects of low-concentration atropine eye drops on pupil size and accommodation in young adult subjects. Graefes Arch Clin Exp Ophthalmol. 2018 Nov;256(11):2211-2217. doi: 10.1007/s00417-018-4112-8.
14. Aleman AC, Wang M, Schaeffel F. Reading and Myopia: Contrast Polarity Matters. Sci Rep. 2018 Jul 18;8(1):10840. doi: 10.1038/s41598-018-28904-x.
15. Aleman A, Schaeffel F. Lag of accommodation does not predict changes in eye growth in chickens. Vision Res. 2018 Aug;149:77-85. doi: 10.1016/j.visres.2018.06.007.
16. Schaeffel F. All about restraining eye growth: the 16th International Myopia Conference in Birmingham, UK. Ophthalmic Physiol Opt. 2018 May;38(3):210-214. doi: 10.1111/opo.12458. No abstract available.
17. Gisbert S, Schaeffel F. M to L cone ratios determine eye sizes and baseline refractions in chickens. Exp Eye Res. 2018 Jul;172:104-111. doi: 10.1016/j.exer.2018.03.029. Epub 2018 Mar 30.
18. García MG, Ohlendorf A, Schaeffel F, Wahl S. Dioptric defocus maps across the visual field for different indoor environments. Biomed Opt Express. 2017 Dec 22;9(1):347-359. doi: 10.1364/BOE.9.000347.
19. Schaeffel F. [Comparative analysis of light sensitivity, depth and motion perception in animals and humans]. Ophthalmologe. 2017 Nov;114(11):997-1007. doi: 10.1007/s00347-017-0568-x. Review. German.
20. Lagrèze WA, Schaeffel F. Preventing Myopia. Dtsch Arztebl Int. 2017 Sep 4;114(35-36):575-580. doi: 10.3238/arztebl.2017.0575.
21. Schaeffel F. [Visual performance of animals and humans in comparison]. Ophthalmologe. 2017 Nov;114(11):976-977. doi: 10.1007/s00347-017-0569-9. German. No abstract available.
22. Maedel S, Hirnschall N, Bayer N, Markovic S, Tabernero J, Artal P, Schaeffel F, Findl O. Comparison of intraocular lens decentration and tilt measurements using 2 Purkinje meter systems. J Cataract Refract Surg. 2017 May;43(5):648-655. doi: 10.1016/j.jcrs.2017.01.022.
23. Baden T, Schaeffel F, Berens P. Visual Neuroscience: A Retinal Ganglion Cell to Report Image Focus? Curr Biol. 2017 Feb 20;27(4):R139-R141. doi: 10.1016/j.cub.2016.12.022.
24. Schaeffel F, Smith EL 3rd. Inhibiting Myopia by (Nearly) Invisible Light? EBioMedicine. 2017 Feb;16:27-28. doi: 10.1016/j.ebiom.2017.01.016. No abstract available.
25. Maier F, Wahl S, Schaeffel F. Off-axis astigmatism in the isolated chicken crystalline lens. Vision Res. 2016 Dec;129:61-68. doi: 10.1016/j.visres.2016.10.005.
26. Schaeffel F. [Biological mechanisms of myopia]. Ophthalmologe. 2017 Jan;114(1):5-19. doi: 10.1007/s00347-016-0388-4. Review. German.
27. Wagner S, Ohlendorf A, Schaeffel F, Wahl S. Reducing the lag of accommodation by auditory biofeedback: A pilot study. Vision Res. 2016 Dec;129:50-60. doi: 10.1016/j.visres.2016.10.002.
28. Schaeffel F, Feldkaemper M. Myopia and Outdoor Exposures. Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4790. doi: 10.1167/iovs.16-20540. No abstract available.
29. Lagrèze WA, Joachimsen L, Schaeffel F. [Current recommendations for deceleration of myopia progression]. Ophthalmologe. 2017 Jan;114(1):24-29. doi: 10.1007/s00347-016-0346-1. Review. German.
30. Schaeffel F. Myopia-What is Old and What is New? Optom Vis Sci. 2016 93(9):1022–1030
31. Schaeffel F, Feldkaemper M. Animal models in myopia research. Clin Exp Optom. 2015 Nov;98(6):507-17. doi: 10.1111/cxo.12312. Review.
32. Lan W, Yang Z, Feldkaemper M, Schaeffel F. Changes in dopamine and ZENK during suppression of myopia in chicks by intense illuminance. Exp Eye Res. 2016 Apr;145:118-124. doi: 10.1016/j.exer.2015.11.018.
33. Janunts E, Chashchina E, Seitz B, Schaeffel F, Langenbucher A. Reliability of a Single Light Source Purkinjemeter in Pseudophakic Eyes. Optom Vis Sci. 2015 Aug;92(8):884-91. doi: 10.1097/OPX.0000000000000644.
34. Schaeffel F, Starostzik C. [Does outdoor play prevent myopia]. MMW Fortschr Med. 2015 May 28;157(10):8. doi: 10.1007/s15006-015-3103-5. German. No abstract available.
35. Maier FM, Howland HC, Ohlendorf A, Wahl S, Schaeffel F. Lack of oblique astigmatism in the chicken eye. Vision Res. 2015 Apr;109(Pt A):68-76. doi: 10.1016/j.visres.2015.02.002. Epub 2015 Feb 18.
36. Chen Y, Lan W, Schaeffel F. Size of the foveal blue scotoma related to the shape of the foveal pit but not to macular pigment. Vision Res. 2015 Jan;106:81-9. doi: 10.1016/j.visres.2014.10.011. Epub 2014 Nov 15.
37. Lan W, Feldkaemper M, Schaeffel F. Intermittent episodes of bright light suppress myopia in the chicken more than continuous bright light. PLoS One. 2014 Oct 31;9(10):e110906. doi: 10.1371/journal.pone.0110906. eCollection 2014.
38. Schaeffel F. Does emmetropization need rods? Invest Ophthalmol Vis Sci. 2014 Oct 8;55(10):6280. doi: 10.1167/iovs.14-15524. No abstract available.
39. Jiang L, Long K, Schaeffel F, Zhou X, Zheng Y, Ying H, Lu F, Stell WK, Qu J. Effects of dopaminergic agents on progression of naturally occurring myopia in albino guinea pigs (Cavia porcellus). Invest Ophthalmol Vis Sci. 2014 Sep 30;55(11):7508-19. doi: 10.1167/iovs.14-14294.
40. Mathis U, Ziemssen F, Schaeffel F. Effects of a human VEGF antibody (Bevacizumab) on deprivation myopia and choroidal thickness in the chicken. Exp Eye Res. 2014 Oct;127:161-9. doi: 10.1016/j.exer.2014.07.022.
41. Chen Y, Schaeffel F. Crystalline lens thickness determines the perceived chromatic difference in magnification. J Opt Soc Am A Opt Image Sci Vis. 2014 Mar 1;31(3):524-31. doi: 10.1364/JOSAA.31.000524.
42. Bueno JM, Palacios R, Giakoumaki A, Gualda EJ, Schaeffel F, Artal P. Retinal cell imaging in myopic chickens using adaptive optics multiphoton microscopy. Biomed Opt Express. 2014 Feb 7;5(3):664-74. doi: 10.1364/BOE.5.000664.
43. Lan W, Schaeffel F. Authors' response. Optom Vis Sci. 2014 Apr;91(4):e94-5. doi: 10.1097/OPX.0000000000000208.
44. Iribarren R, Rozema JJ, Schaeffel F, Morgan IG. Calculation of crystalline lens power in chickens with a customized version of Bennett's equation. Vision Res. 2014 Mar;96:33-8. doi: 10.1016/j.visres.2014.01.003.
45. Jiang L, Zhang S, Schaeffel F, Xiong S, Zheng Y, Zhou X, Lu F, Qu J. Interactions of chromatic and lens-induced defocus during visual control of eye growth in guinea pigs (Cavia porcellus). Vision Res. 2014 Jan;94:24-32. doi: 10.1016/j.visres.2013.10.020.
46. Mutti DO, Gwiazda J, Norton TT, Smith EL 3rd, Schaeffel F, To CH. Myopia--yesterday, today, and tomorrow. Optom Vis Sci. 2013 Nov;90(11):1161-4. doi: 10.1097/OPX.0000000000000117. No abstract available.
47. Wildenmann U, Schaeffel F. Variations of pupil centration and their effects on video eye tracking. Ophthalmic Physiol Opt. 2013 Nov;33(6):634-41. doi: 10.1111/opo.12086. Epub 2013 Sep 17. Erratum in: Ophthalmic Physiol Opt. 2014 Jan;34(1):123.
48. Lan W, Feldkaemper M, Schaeffel F. Bright light induces choroidal thickening in chickens. Optom Vis Sci. 2013 Nov;90(11):1199-206. doi: 10.1097/OPX.0000000000000074.
49. Maier FM, Schaeffel F. Is adaptation to perceived interocular differences in height explained by vertical fusional eye movements? Invest Ophthalmol Vis Sci. 2013 Jul 24;54(7):5020-6. doi: 10.1167/iovs.13-11857.
50. Schaeffel F, Wildsoet C. Can the retina alone detect the sign of defocus? Ophthalmic Physiol Opt. 2013 May;33(3):362-7. doi: 10.1111/opo.12058.
51. Feldkaemper M, Schaeffel F. An updated view on the role of dopamine in myopia. Exp Eye Res. 2013 Sep;114:106-19. doi: 10.1016/j.exer.2013.02.007. Epub 2013 Feb 19. Review.
52. Penha AM, Burkhardt E, Schaeffel F, Feldkaemper MP. Effects of intravitreal insulin and insulin signaling cascade inhibitors on emmetropization in the chick. Mol Vis. 2012;18:2608-22. Epub 2012 Oct 20.
53. Schaeffel F. [Clinical risk factors for progressive myopia]. Ophthalmologe. 2012 Aug;109(8):738-48. doi: 10.1007/s00347-011-2497-4. German.
54. Penha AM, Burkhardt E, Schaeffel F, Feldkaemper MP. Ultrasonography and optical low-coherence interferometry compared in the chicken eye. Optom Vis Sci. 2012 Jun;89(6):916-21. doi: 10.1097/OPX.0b013e318257a255.
55. Jaeken B, Tabernero J, Schaeffel F, Artal P. Comparison of two scanning instruments to measure peripheral refraction in the human eye. J Opt Soc Am A Opt Image Sci Vis. 2012 Mar 1;29(3):258-64. doi: 10.1364/JOSAA.29.000258.
56. Tabernero J, Ohlendorf A, Fischer MD, Bruckmann AR, Schiefer U, Schaeffel F. Peripheral refraction in pseudophakic eyes measured by infrared scanning photoretinoscopy. J Cataract Refract Surg. 2012 May;38(5):807-15. doi: 10.1016/j.jcrs.2011.11.040.
57. Graef K, Schaeffel F. Control of accommodation by longitudinal chromatic aberration and blue cones. J Vis. 2012 Jan 18;12(1):14. doi: 10.1167/12.1.14.
58. Tepelus TC, Vazquez D, Seidemann A, Uttenweiler D, Schaeffel F. Effects of lenses with different power profiles on eye shape in chickens. Vision Res. 2012 Feb 1;54:12-9. doi: 10.1016/j.visres.2011.11.014. Epub 2011 Dec 13.
59. Penha AM, Burkhardt E, Schaeffel F, Feldkaemper MP. Ultrasonography and optical low-coherence interferometry compared in the chicken eye. Optom Vis Sci. 2012 Jun;89(6):916-21.
60. Jaeken B, Tabernero J, Schaeffel F, Artal P. Comparison of two scanning instruments to measure peripheral refraction in the human eye. J Opt Soc Am A Opt Image Sci Vis. 2012 Mar 1;29(3):258-64.
61. Tabernero J, Ohlendorf A, Fischer MD, Bruckmann AR, Schiefer U, Schaeffel F. Peripheral refraction in pseudophakic eyes measured by infrared scanning photoretinoscopy. J Cataract Refract Surg. 2012 May;38(5):807-15.
62. Graef K, Schaeffel F. Control of accommodation by longitudinal chromatic aberration and blue cones. J Vis. 2012 Jan 18;12-21(1)
63. Tepelus TC, Vazquez D, Seidemann A, Uttenweiler D, Schaeffel F. Effects of lenses with different power profiles on eye shape in chickens. Vision Res. 2011 Dec 13;54C:12-19
64. Schaeffel F. Myopia update 2011. Klin Monbl Augenheilkd. 2011 Sep;228(9):754-6 (in German)
65. Bueno JM, Giakoumaki A, Gualda EJ, Schaeffel F, Artal P. Analysis of the chicken retina with an adaptive optics multiphoton microscope. Biomed Opt Express. 2011 Jun 1;2(6):1637-48
66. Jiang L, Long K, Schaeffel F, Zhang S, Zhou X, Lu F, Qu J. Disruption of emmetropization and high susceptibility to deprivation myopia in albino guinea pigs.Invest Ophthalmol Vis Sci. 2011 Aug 3;52(9):6124-32
67. Penha AM, Schaeffel F, Feldkaemper M. Insulin, insulin-like growth factor-1, insulin receptor, and insulin-like growth factor-1 receptor expression in the chick eye and their regulation with imposed myopic or hyperopic defocus. Mol Vis. 2011;17:1436-48
68. Ohlendorf A, Tabernero J, Schaeffel F. Visual acuity with simulated and real astigmatic defocus. Optom Vis Sci. 2011 May;88(5):562-9
69. Chen YP, Hocking PM, Wang L, Povazay B, Prashar A, To CH, Erichsen JT, Feldkaemper M, Hofer B, Drexler W, Schaeffel F, Guggenheim JA. Selective breeding for susceptibility to myopia reveals a gene-environment interaction. Invest Ophthalmol Vis Sci. 2011 Jun 8;52(7):4003-11
70. Mutti DO, Schaeffel F, Feldkaemper M. 13th International Conference on Myopia.Optom Vis Sci. 2011 Mar;88(3):362-4
71. Ohlendorf A, Tabernero J, Schaeffel F. Neuronal adaptation to simulated and optically-induced astigmatic defocus. Vision Res. 2011 Mar 25;51(6):529-34
72. Tabernero J, Ohlendorf A, Fischer MD, Bruckmann AR, Schiefer U, Schaeffel F. Peripheral refraction profiles in subjects with low foveal refractive errors. Optom Vis Sci. 2011 Mar;88(3):E388-9
73. Ashby RS, Schaeffel F. The effect of bright light on lens compensation in chicks. Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5247-53
74. Mathis U, Schaeffel F. Transforming growth factor-beta in the chicken fundal layers: an immunohistochemical study. Exp Eye Res. 2010 Jun;90(6):780-790
75. Schippert R, Schaeffel F, Feldkaemper MP. Microarray analysis of retinal gene expression in Egr-1 knockout mice. Mol Vis. 2009 Dec 10;15:2720-2739
76. Diedrich E, Schaeffel F. Spatial resolution, contrast sensitivity, and sensitivity to defocus of chicken retinal ganglion cells in vitro. Vis Neurosci. 2009 Nov;26(5-6):467-476
77. Tepelus TC, Schaeffel F. Individual set-point and gain of emmetropization in chickens. Vision Res. 2010 Jan;50(1):57-64
78. Tabernero J, Schaeffel F. Fast scanning photoretinoscope for measuring peripheral refraction as a function of accommodation. J Opt Soc Am A Opt Image Sci Vis. 2009 Oct;26(10):2206-2210
79. Chen YP, Prashar A, Hocking PM, Erichsen JT, To CH, Schaeffel F, Guggenheim JA. Sex, eye size, and the rate of myopic eye growth due to form deprivation in outbred white leghorn chickens. Invest Ophthalmol Vis Sci. 2010 Feb;51(2):651-657
80. Tabernero J, Vazquez D, Seidemann A, Uttenweiler D, Schaeffel F. Effects of myopic spectacle correction and radial refractive gradient spectacles on peripheral refraction. Vision Res. 2009 Aug;49(17):2176-2186
81. Ashby R, Ohlendorf A, Schaeffel F. The effect of ambient illuminance on the development of deprivation myopia in chicks. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5348-5354
82. Tabernero J, Schaeffel F. More irregular eye shape in low myopia than in emmetropia. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4516-4522
83. Barathi VA, Beuerman RW, Schaeffel F. Effects of unilateral topical atropine on binocular pupil responses and eye growth in mice. Vision Res. 2009 Feb;49(3):383-387
84. Jiang L, Schaeffel F, Zhou X, Zhang S, Jin X, Pan M, Ye L, Wu X, Huang Q, Lu F, Qu J. Spontaneous axial myopia and emmetropization in a strain of wild-type guinea pig (Cavia porcellus). Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1013-1019.
85. Ohlendorf A, Schaeffel F. Contrast adaptation induced by defocus - A possible error signal for emmetropization? Vision Res. 2009 Jan;49(2):249-256
86. Feldkaemper MP, Neacsu I, Schaeffel F. Insulin acts as a powerful stimulator of axial myopia in chicks. Invest Ophthalmol Vis Sci. 2009 Jan;50(1):13-23
87. Schippert R, Schaeffel F, Feldkaemper MP.Microarray analysis of retinal gene expression in chicks during imposed myopic defocus. Mol Vis. 2008 Aug 31;14:1589-1599.
88. Schaeffel F. Test systems for measuring ocular parameters and visual function in mice. Front Biosci. 2008 May 1;13:4904-4911.
89. Schaeffel F. Binocular lens tilt and decentration measurements in healthy subjects with phakic eyes. Invest Ophthalmol Vis Sci. 2008 May;49(5):2216-2222.
90. Brand C, Schaeffel F, Feldkaemper MP. A microarray analysis of retinal transcripts that are controlled by image contrast in mice. Mol Vis. 2007 Jun 18;13:920-932.
91. Schaeffel F, Mathis U, Brüggemann G. Noncycloplegic photorefractive screening in pre-school children with the "PowerRefractor" in a pediatric practice. Optom Vis Sci. 2007 Jul;84(7):630-639.
92. Schippert R, Burkhardt E, Feldkaemper M, Schaeffel F. Relative axial myopia in Egr-1 (ZENK) knockout mice. Invest Ophthalmol Vis Sci. 2007 Jan;48(1):11-7.
93. Diether S, Schaeffel F, Lambrou GN, Fritsch C, Trendelenburg AU. Effects of intravitreally and intraperitoneally injected atropine on two types of experimental myopia in chicken. Exp Eye Res. 2007 Feb;84(2):266-74
94. Mathis U, Schaeffel F.Glucagon-related peptides in the mouse retina and the effects of deprivation of form vision. Graefes Arch Clin Exp Ophthalmol. 2007 Feb;245(2):267-75.