Experimental Vitreoretinal Surgery

Experimentelle Vitreoretinale Chirurgie

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Research topic

The focus of our section lies on the role of the retinal pigment epithelium (RPE) which is located between the choroid and the neural retina. The RPE is a vital tissue for the maintenance of photoreceptor function and it is also affected by many diseases of the retina and choroid like age–related macular degeneration (AMD). The two major pigments of the RPE are melanin and lipofuscin whose roles in the eye remain somewhat speculative. The questions we are working on are, e.g: what role do melanin and lipofuscin play in health and disease? How can lipofuscin be removed from the RPE? Why does the RPE partially lose its function in elderly people, and how can the function of the RPE be maintained or even restored?

Our other research interests are: Transport of proteins after intravitreal application, gene and pharmacological therapies, mechanisms of pathological neovascularisation, generation of relevant cellular and animal models for preclinical studies, retinoblastoma and Stargardt disease.