Seeliger Lab

Ocular Neurodegeneration

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Vithiyanjali Sothilingam

SurnameSothilingam
First nameVithiyanjali
NationalityGerman
Present position and titlePost-Doc (Dr. rer. nat.), Electrodiagnostic specialist

Business address

Institute for Ophthalmic Research
Centre for Ophthalmology,
University of Tübingen
Elfriede-Aulhorn-Straße 7
72076 Tübingen
Germany

Phone: +49 (0)7071 29-87767
Fax: +49 (0)7071 29-4503
E-mail: vithiyanjali.sothilingam[at]med.uni-tuebingen.de

Academic Education

Year Degree University Field of study
11/2010 - 05 / 2016 Doctoral thesis University of Tuebingen
03/2010 Diplom Hohenheim University, Germany Biology

Professional Experience

Period Institution Position Discipline
Since
06/2016
Division of Ocular Neurodegeneration, Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen Post-Doc
04/2010-
09/2010
Institute of Physiology, University Hohenheim Research associate

Research Interests

  • Electrophysiology (Electroretinography)
  • Animal model for hereditary retinal diseases
  • Retinal physiology and pathophysiology

Additional information

Awards

01/2014 Recipient of the Swiss Retina Award for Young researcher at Eye Research Meeting, Biel, Switzerland

Publications

  1. Sothilingam V, Michalakis S, Garcia Garrido M, Biel M, Tanimoto N, Seeliger MW. HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure. PLoS One. 2016;11:e0147728.
  2. Schön C, Asteriti S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Herms J, Seeliger MW, Cangiano L, Biel M, Michalakis S. Loss of HCN1enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia. Hum Mol Genet. 2016;25:1165-1175.
  3. Sothilingam V*, Garcia Garrido M*, Jiao K*, Buena-Atienza E, Sahaboglu A, Trifunović D, Balendran S, Koepfli T, Mühlfriedel R, Schön C, Biel M, Heckmann A, Beck SC, Michalakis S, Wissinger B, Seeliger MW, Paquet- Durand F. Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype. Hum Mol Genet. 2015;24:5486-5499.
  4. Tanimoto N, Sothilingam V, Kondo M, Biel M, Humphries P, Seeliger MW. Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice. Sci Rep. 2015;5:10731.
  5. Katiyar R, Weissgerber P, Roth E, Dörr J, Sothilingam V, Garcia Garrido M, Beck SC, Seeliger MW, Beck A, Schmitz F, Flockerzi V. Influence of the β2-Subunit of L-Type Voltage-Gated Cav Channels on the Structural and Functional Development of Photoreceptor Ribbon Synapses. Invest Ophthalmol Vis Sci. 2015;56:2312-2324.
  6. Michalakis S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Schulze E, Becirovic E, Koch F, Seide C, Beck SC, Seeliger MW, Mühlfriedel R, BielM. Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa. Adv Exp Med Biol. 2014;801:733-739.
  7. Michalakis S, Shaltiel L, Sothilingam V, Koch S, Schludi V, Krause S, Zeitz C, Audo I, Lancelot ME, Hamel C, Meunier I, Preising MN, Friedburg C, Lorenz B, Zabouri N, Haverkamp S, Garcia Garrido M, Tanimoto N, Seeliger MW, Biel M, Wahl-Schott CA. Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2. Hum Mol Genet. 2014;23:1538-1550.
  8. Knoflach D, Kerov V, Sartori SB, Obermair GJ, Schmuckermair C, Liu X, Sothilingam V, Garcia Garrido M, Baker SA, Glösmann M, Schicker K, Seeliger M, Lee A, Koschak A. Cav1.4 IT mouse as model for vision impairment in human congenital stationary night blindness type 2. Channels (Austin). 2013;7:503-513.
  9. Tanimoto N, Sothilingam V, Seeliger MW. Functional phenotyping of mouse models with ERG. Methods Mol Biol. 2013;935:69-78.
  10. Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Becirovic E, Koch F, Seide C, Beck SC, Seeliger MW, Biel M, Mühlfriedel R, Michalakis S. Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa. Hum Mol Genet. 2012;21:4486-4496.