Seeliger Lab

Ocular Neurodegeneration

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Vithiyanjali Sothilingam

First nameVithiyanjali
Present position and titlePost-Doc (Dr. rer. nat.), Electrodiagnostic specialist

Business address

Institute for Ophthalmic Research
Centre for Ophthalmology,
University of Tübingen
Elfriede-Aulhorn-Straße 7
72076 Tübingen

Phone: +49 (0)7071 29-87767
Fax: +49 (0)7071 29-4503
E-mail: vithiyanjali.sothilingam[at]

Academic Education

Year Degree University Field of study
11/2010 - 05 / 2016 Doctoral thesis University of Tuebingen
03/2010 Diplom Hohenheim University, Germany Biology

Professional Experience

Period Institution Position Discipline
Division of Ocular Neurodegeneration, Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen Post-Doc
Institute of Physiology, University Hohenheim Research associate

Research Interests

  • Electrophysiology (Electroretinography)
  • Animal model for hereditary retinal diseases
  • Retinal physiology and pathophysiology

Additional information


01/2014 Recipient of the Swiss Retina Award for Young researcher at Eye Research Meeting, Biel, Switzerland


  1. Sothilingam  V,  Garcia  Garrido  M,  Beck  SC,  Mühlfriedel  R,  Seeliger  MW  (2018) Nichtinvasive Bildgebung der Netzhaut zur Reduktion konventioneller präklinischer Histologie. Berl Münch Tierärztl Wochenschr;131:401-40.
  2. Burkard M, Kohl S, Krätzig T, Tanimoto N, Brennenstuhl C, Bausch AE, Junger K, Reuter P, Sothilingam V, Beck SC, Huber G, Ding XQ, Mayer AK, Baumann B, Weisschuh N, Zobor D, Hahn GA, Kellner U, Venturelli S, Becirovic E, Charbel Issa P, Koenekoop RK, Rudolph G, Heckenlively J, Sieving P, Weleber RG, Hamel C, Zong X, Biel M, Lukowski R, Seeliger MW, Michalakis S, Wissinger B, Ruth P. Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy. J Clin Invest. 2018;128:5663-5675.
  3. Mühlfriedel R, Michalakis S, Garrido MG, Sothilingam V, Schön C, Biel M, Seeliger MW. Optimized Subretinal Injection Technique for Gene Therapy Approaches. Methods Mol Biol. 2019;1834:405-412.
  4. Kahle NA, Peters T, Zobor D, Kuehlewein L, Kohl S, Zhour A, Werner A, Seitz IP, Sothilingam V, Michalakis S, Biel M, Ueffing M, Zrenner E, Bartz-Schmidt KU, Fischer MD, Wilhelm BJC. Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial. Hum Gene Ther Clin Dev. 2018;29:121-131.
  5. Beck SC, Karlstetter M, Garcia Garrido M, Feng Y, Dannhausen K, Mühlfriedel R, Sothilingam V, Seebauer B, Berger W, Hammes HP, Seeliger MW, Langmann T. Cystoid edema, neovascularization and inflammatory processes in the murine Norrin-deficient retina. Sci Rep. 2018;8:5970.
  6. Schön C*, Sothilingam V*, Mühlfriedel R, Garcia Garrido M, Beck SC, Tanimoto N, Wissinger B, Paquet-Durand F, Biel M, Michalakis S, Seeliger MW, Consortium RC Gene therapy successfully delays degeneration in a mouse model of PDE6A-linked retinitis pigmentosa (RP 43). Hum Gene Ther. 2017;28:1180-1188. * Equal Contribution.
  7. Sothilingam V, Mühlfriedel R, Tanimoto N, Seeliger MW. In-Depth Functional Analysis of Rodents by Full-Field Electroretinography. Methods Mol Biol. 2018;1715:207-213.
  8. Mühlfriedel R, Tanimoto N, Schön C, Sothilingam V, Garcia Garrido M, Beck SC, Huber G, Biel M, Seeliger MW, Michalakis S. AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects. Front Neurosci. 2017;11:292.
  9. Beck SC, Feng Y, Sothilingam V, Garcia Garrido M, Tanimoto N, Acar N, Shan S, Seebauer B, Berger W, Hammes HP, Seeliger MW. Long-term consequences of developmental vascular defects on retinal vessel homeostasis and function in a mouse model of Norrie disease. PLoS One. 2017;2;e0178753.
  10. Mühlfriedel R, Sothilingam V, Tanimoto N, Seeliger MW. Gene Replacement Therapy for Inherited Retinal Dystrophies. Klin Monbl Augenheilkd. 2017;234:320-328.
  11. Stojic A, Fairless R, Beck SC, Sothilingam V, Weissgerber P, Wissenbach U, Gimmy V, Seeliger MW, Flockerzi V, Diem R, Williams SK. Murine Autoimmune Optic Neuritis Is Not Phenotypically Altered by the Retinal Degeneration 8 Mutation. Invest Ophthalmol Vis Sci. 2017;58:318-328.
  12. Sothilingam V, Michalakis S, Garcia Garrido M, Biel M, Tanimoto N, Seeliger MW. HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure. PLoS One. 2016;11:e0147728.
  13. Schön C, Asteriti S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Herms J, Seeliger MW, Cangiano L, Biel M, Michalakis S. Loss of HCN1enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia. Hum Mol Genet. 2016;25:1165-1175.
  14. Sothilingam V*, Garcia Garrido M*, Jiao K*, Buena-Atienza E, Sahaboglu A, Trifunović D, Balendran S, Koepfli T, Mühlfriedel R, Schön C, Biel M, Heckmann A, Beck SC, Michalakis S, Wissinger B, Seeliger MW, Paquet- Durand F. Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype. Hum Mol Genet. 2015;24:5486-5499. * Equal Contribution
  15. Tanimoto N, Sothilingam V, Kondo M, Biel M, Humphries P, Seeliger MW. Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice. Sci Rep. 2015;5:10731.
  16. Katiyar R, Weissgerber P, Roth E, Dörr J, Sothilingam V, Garcia Garrido M, Beck SC, Seeliger MW, Beck A, Schmitz F, Flockerzi V. Influence of the β2-Subunit of L-Type Voltage-Gated Cav Channels on the Structural and Functional Development of Photoreceptor Ribbon Synapses. Invest Ophthalmol Vis Sci. 2015;56:2312-2324.
  17. Michalakis S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Schulze E, Becirovic E, Koch F, Seide C, Beck SC, Seeliger MW, Mühlfriedel R, BielM. Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa. Adv Exp Med Biol. 2014;801:733-739.
  18. Michalakis S, Shaltiel L, Sothilingam V, Koch S, Schludi V, Krause S, Zeitz C, Audo I, Lancelot ME, Hamel C, Meunier I, Preising MN, Friedburg C, Lorenz B, Zabouri N, Haverkamp S, Garcia Garrido M, Tanimoto N, Seeliger MW, Biel M, Wahl-Schott CA. Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2. Hum Mol Genet. 2014;23:1538-1550.
  19. Knoflach D, Kerov V, Sartori SB, Obermair GJ, Schmuckermair C, Liu X, Sothilingam V, Garcia Garrido M, Baker SA, Glösmann M, Schicker K, Seeliger M, Lee A, Koschak A. Cav1.4 IT mouse as model for vision impairment in human congenital stationary night blindness type 2. Channels (Austin). 2013;7:503-513.
  20. Tanimoto N, Sothilingam V, Seeliger MW. Functional phenotyping of mouse models with ERG. Methods Mol Biol. 2013;935:69-78.
  21. Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Becirovic E, Koch F, Seide C, Beck SC, Seeliger MW, Biel M, Mühlfriedel R, Michalakis S. Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa. Hum Mol Genet. 2012;21:4486-4496.