Review on Therapeutic targeting of the complement system in ocular disease
The complement system has been found to be involved in the pathogenesis of several ocular diseases providing a rationale for the investigation of complement-targeting therapeutics for these conditions.
The complement system is a complex part of the immune system in the human body. It consists of a group of proteins that work together to support the immune response. However, when the complement system becomes overactive or dysregulated, it can contribute to various diseases and conditions, including autoimmune disorders and some eye diseases, such as corneal diseases, uveitis, glaucoma, diabetic retinopathy, multiple sclerosis, and AMD (age-related macular degeneration). This discovery suggests that it is worth exploring therapeutic approaches that specifically target the complement system to treat these conditions.
The authors of this review, Sonika Rathi, Marius Ueffing, Simon J. Clark of the Institute for Ophthalmic Research in Tübingen and Rafiq Hasan of Complement Therapeutics, London, want to discuss the role of complement in ocular disease, providing an overview of the complement-targeting agents currently under development for ocular conditions, and want to reflect on the lessons that can be learned from the preclinical investigations and clinical trials conducted in this field to date.
Link to the review https://doi.org/10.1016/j.drudis.2023.103757
