Date: 26.02.2021


Feb 202126Friday

Highlight Seminar of the Centre for Neurosensory Systems - Dr. Deniz Dalkara

Date / Time
26.02.2021 11:00 12:00
Center for Neurosensory Systems
Titel: Retinal Gene Therapy for Vision Restoration
Lecturer: Deniz Dalkara PhD, Institut de la Vision, Paris
Date: February 26th, 2021, 11:00-12:00h CET

Retinal Gene Therapy for Vision Restoration

Gene therapy using adeno-associated viral (AAV) vectors has shown early promise in the clinic, particularly for retinal gene therapy. The therapeutic transgene cassette can be packaged into different AAV capsid variants, each having a unique transduction profile. At present, AAV capsid serotype selection for a specific clinical trial is based on effectiveness in small animal models. Substantial progress has been made in improving effectiveness of gene therapy for eye diseases in rodents. This includes selection of the vector and promoter combination and testing phenotypic outcomes in relevant model systems. Here, I will decribe recent work from my group on developing gene therapy and gene delivery strageties for treatment of retinitis pigmentosa. Our innovative therapies aim to restore vision in late stages of the disease with a special focus on high acuity vision.

Dr. Deniz Dalkara

Deniz Dalkara is a tenured researcher in INSERM, France and leads a team on gene therapies and animal models of neurodegenerative disease at the Vision Institute in Paris. She graduated from Middle East technical University with a B.S. degree in Biology in 2001. Afterwards, she obtained a masters degree in pharmacology and pharmacochemistry in Strasbourg, France where she later pursued a PhD degree in cellular and molecular aspects of biology. She was awarded the Biovalley PhD thesis for method of protein delivery developed during her graduate studies.

Later on she conducted a postdoctoral fellowship in the laboratory of Ernst Babmerg at the Max Planck Institute of Biophysics before moving on to UC Berkeley to do a second post-doctoral training in 2007. At UC Berkeley, Dr Dalkara applied viral engineering principals to enhance AAV vectors for their application in retinal degenerative diseases. Her work includes molecular evolution and engineering of viral gene delivery vehicles and their application to develop innovative gene therapeutic strategies to combat blinding diseases of the retina.

For her work in this area, she received Euretina Science and Medicine Innovation award in 2013 and she was selected Innovator under 35 –France by MIT Technology Review in 2014. Dr Dalkara received the Young Investigator award to start her group at the Vision Institute in Paris and has been carrying on her research activities in this research institute with a strong focus on translational research.

Releated Files

  • zfn-plakat_hss_deniz_dalkara_dina3-v01-2021-01-29.pdf
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