Institute for Ophthalmic Research

Institut für Augenheilkunde

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PhD student (f/m/d)

The group of Prof. Marius Ueffing at the Institute for Ophthalmic Research is looking for a PhD student (f/m/d) with high interest in molecular and cell biology for the

“Multimodal analysis of CRB1 related retinal degeneration in human iPSC derived organoids.”

The PhD position (65%) is funded by the DFG Priority Programme 2127: Gene and cell based therapies to counteract neuroretinal degeneration and is initially limited to 30.04.2022.

Project description:

Retinal degeneration affecting photoreceptors, either inherited or age-related, leads to a mostly progressive loss of vision and subsequent blindness. One of the factors involved in an autosomal recessive early onset and severe form of Retinitis Pigmentosa (RP) is the “Crumbs Homolog 1” (CRB1). The project aims at generating knowledge and providing candidate targets for interventional therapy of patients suffering from CRB1 associated retinal degeneration.

Your tasks:

  • development of different tools to investigate CRB1-related pathomechanisms
  • cultivation of control and patient specific induced pluripotent stem cells (iPSCs)
  • generation of retinal organoids from patient iPSCs carrying homozygous mutations in the CRB1 gene
  • analysis of patient specific deregulations of global gene expression by RNAseq
  • analysis of protein expression and protein interactions dependent on CRB1
  • investigating the role of CRB1 in cellular signalling pathways
  • high-resolution microscopy imaging techniques (2 -Photon, STED und EM)

Required qualifications:

We are looking for a highly motivated candidate with a degree in life sciences (diploma/ masters) and a strong background in cell and molecular biology. Experience in cell culture and cloning would be an advantage. Experience in vision science, neurobiology or protein science is preferred.

What we offer:

The Institute for Ophthalmic Research ( is an integral part of the Centre for Ophthalmology as well as the Quantitative Biology Center at the University of Tübingen ( We can offer to work in a team of highly motivated scientists, a stimulating atmosphere and access to advanced technical infrastructure.

We offer remuneration in accordance with TV-L (collective wage agreement for the Public Service of the German Federal States) in addition to all the customary benefits granted to employees working in Public Services. Severely handicapped persons with equal qualifications are given preferential consideration. The University of Tübingen is anxious to increase its quota of female scientific staff, and therefore emphatically requests women to apply for this position. The Administration of the University Hospital is responsible for all employment matters. Personnel appointments will be made pursuant to the fundamental stipulations of the legal statutes for universities in Germany. Interview expenses are not covered.

For further information please contact: Dr. Ellen Kilger, Email: ellen.kilger[at], Phone: +49 (7071) 29-84947, Universitätsklinikum Tübingen, Department für Augenheilkunde: Forschungsinstitut, Elfriede-Aulhorn-Str. 7, 72076 Tübingen.

To apply:

Applicants should address their application to Prof. Marius Ueffing (marius.ueffing[at] referring to Kennziffer 9536. Please send a single pdf file by e-mail, containing a cover letter, CV, copy of final certificates and contact details of two academic referees. The deadline for application is 30.04.2019.

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