Marius Ueffings's group focuses on medical proteomics as well as disease mechanisms. The group teams up with computational and structural biologists to develop and apply molecular and bioanalytical strategies towards functional analysis of protein complexes and protein networks in disease, cellular signaling pathways and disease associated protein networks involved in neurodegeneration. At the technical level, the group has developed a new generation of patented tandem affinity tags allowing fast and efficient complex purification without involving proteolytic cleavage of the tag as well as the investigation of systemic perturbation of protein networks in disease.