Ueffing Lab

Molecular Biology of Retinal Degenerations

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Blanca Arango-Gonzalez

SurnameArango-Gonzalez
First nameBlanca
NationalityColumbian
Present position and titleResearch fellow, Project Leader, Dr. med.

Business address

Institute for Ophthalmic Research
University of Tübingen
Elfriede-Aulhorn-Strasse 7
D-72076 Tübingen,
Germany

Phone: +49 (0)7071 29-80741
Fax: +49 (0)7071 29-5777
E-mail: blanca.arango-gonzalez[at]klinikum.uni-tuebingen.de

Academic Education

Year Degree University Field of study
2008 Dr. med University Eye Hospital, Tübingen Neuroophthalmology
1996 M.D. Universidad Nacional de Colombia Human Medicine

Professional Experience

Period Institution Position Discipline
2011-today Centre for Ophthalmology Project Leader Retinal Neurodegeneration and Neuroprotection
2008-2011 University Eye Hospital, Tübingen Senior Postdoc Retinal Neurodegeneration and Neuroprotection
2006-2008 University Eye Hospital, Tübingen Postdoc Retinal Development and Neuroprotection
2005-2006 Tufts Medical Center Postdoc Retina - Extracellular Matrix
2002-2005 University Eye Hospital and Tübingen University Dr. med. candidate Retinal Neuroprotection
1998-2002 University Eye Hospital, Tübingen Guest scientist Retinal Neuroprotection

Awards

2010“Travel Grant” by the PRO-RETINA-Stiftung zur Verhütung von Blindheit for the Association for Research in Vision and Ophthalmology (ARVO) annual meeting.
2009“American for Research in Vision and Ophthalmology – International Travel Grant” (ARVO).

Memberships and Functions in Scientific Societies

  • German Neuroscience Society (NWG)
  • Association for Research in Vision and Ophthalmology (ARVO).

Publications

  1. Schnichels S, Dorfi T, Schultheiss M, Arango-Gonzalez B, Bartz-Schmidt KU, Januschowski K, Spitzer MS, Ziemssen F. Ex-vivo-examination of ultrastructural changes in organotypic retina culture using near-infrared imaging and optical coherence tomography. Exp Eye Res. 2016 Jun;147:31-6. Epub 2016 Apr 21.
  2. Arango-Gonzalez B#, Trifunović D, Sahaboglu A, Kranz K, Michalakis S, Farinelli P, Koch S, Koch F, Cottet S, Janssen-Bienhold U, Dedek K, Biel M, Zrenner E, Euler T, Ekström P, Ueffing M, Paquet-Durand F. Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration. PLoS One. 2014 Nov 13;9(11):e112142. eCollection 2014.
  3. Haq W, Arango-Gonzalez B, Zrenner E, Euler T, Schubert T. Synaptic remodeling generates synchronous oscillations in the degenerated outer mouse retina. Front Neural Circuits. 2014 Sep 5;8:108. eCollection 2014.
  4. Arango-Gonzalez B, Leitritz MA, Fischer D, Gerberding M, Paquet-Durand F, Ueffing M.  [Current therapeutic approaches in inherited retinal degeneration: from genes to chip]. Klin Monbl Augenheilkd. 2014 Mar;231(3):222-31. doi: 10.1055/s-0033-1360259. Epub 2014 Mar 21. Review. German.
  5. Kucharska J, Del Río P, Arango-Gonzalez B, Gorza M, Feuchtinger A, Hauck SM, Ueffing M. Cyr61 activates retinal cells and prolongs photoreceptor survival in rd1 mouse model of retinitis pigmentosa. J Neurochem. 2014 Jul;130(2):227-40. Epub 2014 Mar 27.
  6. Farinelli P, Arango-Gonzalez B, Völkl J, Alesutan I, Lang F, Zrenner E, Paquet-Durand F, Ekström PA. Retinitis Pigmentosa: Over-expression of anti-ageing protein Klotho in degenerating photoreceptors. J Neurochem. 2013 Dec;127(6):868-79. Epub 2013 Jul 22.
  7. Arango-Gonzalez B, Schatz A, Bolz S, Eslava-Schmalbach J, Willmann G, Zhour A, Zrenner E, Fischer MD, Gekeler F. Effects of combined ketamine-xylazine anesthesia on light-induced retinal degeneration in rats. PLoS One. 2012;7(4):e35687. Epub 2012 Apr 25.
  8. Trifunović D, Sahaboglu A, Kaur J, Mencl S, Zrenner E, Ueffing M, Arango-Gonzalez B#, Paquet-Durand F# Neuroprotective Strategies for the Treatment of Inherited Photoreceptor Degeneration. [# corresponding authors] Curr Mol Med. 2012 Jun;12(5):598-612. Review.
  9. Kaur J, Mencl S, Sahaboglu A, Farinelli P, van Veen T, Zrenner E, Ekström P, Paquet-Durand F, Arango-Gonzalez B. Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant rats. PLoS One. 2011;6(7):e22181. Epub 2011 Jul 12.
  10. Julien S, Peters T, Ziemssen F, Arango-Gonzalez B, Beck S, Thielecke H, Büth H, Van Vlierberghe S, Sirova M, Rossmann P, Rihova B, Schacht E, Dubruel P, Zrenner E, Schraermeyer U. Implantation of ultrathin, biofunctionalized polyimide membranes into the subretinal space of rats. Biomaterials. 2011 Jun;32(16):3890-8.
  11. Del Río P, Irmler M, Arango-González B, Favor J, Bobe C, Bartsch U, Vecino E, Beckers J, Hauck SM, Ueffing M. GDNF-induced osteopontin from Müller glial cells promotes photoreceptor survival in the Pde6b(rd1) mouse model of retinal degeneration. Glia. 2011 May;59(5):821-32. doi: 10.1002/glia.21155. Epub 2011 Feb 28.
  12. Sahaboglu A, Tanimoto N, Kaur J, Sancho-Pelluz J, Huber G, Fahl E, Arango-Gonzalez B, Zrenner E, Ekström P, Löwenheim H, Seeliger M, Paquet-Durand F. PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function. PLoS One. 2010 Nov 23;5(11):e15495.
  13. Arango-Gonzalez B, Szabó A, Pinzon-Duarte G, Lukáts A, Guenther E, Kohler K. In vivo and in vitro development of S- and M-cones in rat retina. Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5320-7. Epub 2010 May 12.
  14. Arango-Gonzalez B, Cellerino A, Kohler K. (2009) Exogenous brain-derived neurotrophic factor (BDNF) reverts phenotypic changes in the retina of transgenic mice lacking the bdnf gene. Investigative Ophthalmology and Visual Science 50(3):1416-22.
  15. Sancho-Pelluz J, Arango-Gonzalez B, Kustermann S, Romero FJ, van Veen T, Zrenner E, Ekström P, Paquet-Durand F. (2008) Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration. Molecular Neurobiology 38(3):253-69.

Patents and Patent Applications

  1. Ueffing, M, Arango-Gonzalez, B, Griciuc, A,
    DE 102013110714 A1, WO 2015044251 A1, PCT/EP2014/070459.
    Prophylaxis and treatment of a neurodegenerative disease not based on a protein folding disorder.