Ueffing Lab

Molecular Biology of Retinal Degenerations

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Dragana Trifunovic

SurnameTrifunovic
First nameDragana
NationalitySerbian
Present position and titleProject leader, PhD

Business address

Institute for Ophthalmic Research
University of Tübingen
Elfriede-Aulhorn-Strasse 7
D-72076 Tübingen,
Germany

Phone: +49 (0)7071 29-84854
E-mail: dragana.trifunovic[at]uni-tuebingen.de

Academic Education

Year Degree University Field of study
2005 - 2008 PhD studies (Marie Curie fellow) in Life Sciences at the Open university of London. PhD title awarded in March 2008. Open University Life Sciences
2000 - 2004 Postgraduate studies of Molecular Biology and Biochemistry, University of Belgrade. Magister of Science (MPhil equivalent) awarded in March 2004. University of Belgrade Molecular Biology and Biochemistry
1994-2000 Studies of Molecular Biology and Physiology at the University of Belgrade. Diploma in Molecular biology and physiology (MSc equivalent) awarded in June 2000. University of Belgrade Molecular Biology and Biochemistry

Professional Experience

Period Position
12/2015 - Project leader of DFG funded project “Evidence based experimental treatment for cone photoreceptor degeneration” at the Tübingen Centre for Ophthalmology, Institute for Ophthalmic Research (Germany)
09/2015 - 12/2015 Project leader of Tistou & Charlotte Kerstan Foundation funded project “HDAC inhibition protects degenerating cone photoreceptors in vivo” at the Tübingen Centre for Ophthalmology, Institute for Ophthalmic Research
09/2014 - 09/2015 Project leader of DFG-Initiation of International Collaboration funded project “Characterization of cell death mechanisms in the central nervous system of rats suffering from experimental autoimmune encephalomyelitis” at the Tübingen Centre for Ophthalmology, Institute for Ophthalmic Research
08/2008 - 08/2015 Post-doctoral fellow at the Tübingen Centre for Ophthalmology, Institute for Ophthalmic Research (group of Dr. Francois Paquet-Durand)
02/2005 - 03/2008 Marie Curie PhD fellow in Tigem (Telethon Institute of Genetics and Medicine), Naples, Italy (groups of Prof. Sandro Banfi and Prof. Valeria Marigo)
02/2001 - 12/2004 Research assistant in the Laboratory for molecular genetics and radiobiology at the Institute of Nuclear Sciences “Vinča”, Belgrade, Serbia (group of Prof. Bogomir Dimitrijevic)

Awards

2016 Retina Suisse Award
2013 DOG Award for project proposal
2010 ARVO Travel Grant
2006 RETNET Mid-term Meeting Award

Funded grants

Institution Applicant (s) Title Reg. No. Funding period Sum
German Research Council (DFG), Bonn, Germany Trifunović Evidence based experimental treatment for cone photoreceptor degeneration TR1238/4-1 2015-18 384.178 €
Kerstan Foundation, Tübingen, Germany Trifunović HDAC inhibition protects degenerating cone photoreceptors in vivo TRI-001/2015 2015 44.000 €
German Research Council (DFG), Bonn, Germany Trifunović,
Miljković (University of Belgrade, Serbia)
Characterization of cell death mechanisms in the central nervous system of rats suffering from experimental autoimmune encephalomyelitis TR1238/2-1 2014-15 10.965 €

Selected Publications

  1. Trifunović D*, Djedović N, Lavrnja I, Wendrich KS, Paquet-Durand F, Miljković D (2015) Cell death of spinal cord ED1+ cells in a rat model of multiple sclerosis. PeerJ 3:e1189.
  2. Sothilingam V, Garcia Garrido M, Jiao K, Buena-Atienza E, Sahaboglu A, Trifunović D, Balendran S, Koepfli T, Mühlfriedel R, Schön C, Biel M, Heckmann A, Beck SC, Michalakis S, Wissinger B, Seeliger MW, Paquet-Durand F (2015). Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype. Hum Mol Genet. 2015 Jul 17. 24(19):5486-99.
  3. Brennenstuhl C, Tanimoto N, Burkard M, Wagner R, Bolz S, Trifunović D, Kabagema-Bilan C, Paquet-Durand F, Beck SC, Huber G, Seeliger MW, Ruth P, Wissinger B, Lukowski R (2015). Targeted ablation of Pde6h in mice reveals cross-species differences in cone and rod phototransduction protein inventory. The Journal of Biological Chemistry, 290(16):10242-55.
  4. Arango-Gonzalez B#, Trifunović D#, Sahaboglu A, Kranz K, Michalakis S, Farinelli P, Koch K, Koch F, Cottet S, Janssen-Bienhold U, Dedek K, Biel M, Zrenner E, Euler T, Ekström P, Ueffing M, Paquet-Durand F (2014). Hereditary retinal degeneration is governed by a common non-apoptotic cell death mechanism. Plos One, 9(11):e112142. #equally contributed
  5. Farinelli P, Perera A,  Arango-Gonzalez B, Trifunović D, Wagner M, Carell T, Biel M, Zrenner E, Michalakis S, Paquet-Durand F, Ekström P (2014). DNA methylation during inherited retinal degeneration.  Cell Death & Disease, 5:e1558.
  6. Trifunović D, Sahaboglu A, Kaur J, Mencl S, Zrenner E, Ueffing M, Arango-Gonzalez B, Paquet-Durand F (2012). Neuroprotective Strategies for the Treatment of Inherited Photoreceptor Degeneration. Current Molecular Medicine, 12:598-612 (Review).
  7. Paquet-Durand F, Beck S, Michalakis S, Goldmann T, Huber G, Mühlfriedel R, Trifunović D, Fischer MD, Fahl E, Duetsch G, Becirovic E, Wolfrum U, van Veen T, Biel M, Tanimoto N, Seeliger MW (2011). A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa. Human Molecular Genetics, 20(5):941-7.
  8. Trifunović D, Dengler K, Michalakis S, Zrenner E, Wissinger B, Paquet-Durand F (2010). cGMP-Dependent Cone Photoreceptor Degeneration in the cpfl1 Mouse Retina. The Journal of Comparative Neurology, 518(17):3604-17.
  9. Trifunović D, Karali M, Camposampiero D, Ponzin D, Banfi S, Marigo V (2008). A high-resolution RNA expression atlas of Retinitis Pigmentosa genes in the human and mouse retinas. Investigative Ophthalmology and Visual Science, 49(6):2330-6.
  10. Trifunović D, Radović M, Ristić Z, Gužvić M, Dimitrijević B (2005). Analysis of electrophoretic patterns of arbitrarily primed PCR profiling. Electrophoresis, 26(22):4277-86.