Ueffing Lab

Molecular Biology of Retinal Degenerations

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2019

  1. Achberger K, Probst C, Haderspeck J, Bolz S, Rogal J, Chuchuy J, Nikolova M, Cora V, Antkowiak L, Haq W, Shen N, Schenke-Layland K, Ueffing M, Liebau S, Loskill P. Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform. Elife. 2019 Aug 27. Epub 2019/08/28. doi: 10.7554/eLife.46188. PubMed PMID: 31451149.
  2. Charitou T, Srihari S, Lynn MA, Jarboui MA, Fasterius E, Moldovan M, Shirasawa S, Tsunoda T, Ueffing M, Xie J, Xin J, Wang X, Proud CG, Boldt K, Al-Khalili Szigyarto C, Kolch W, Lynn DJ. Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRAS(G13D) mutation. Br J Cancer. 2019 Jul. Epub 2019/05/28. doi: 10.1038/s41416-019-0477-7. PubMed PMID: 31133691.
  3. Cora V, Haderspeck J, Antkowiak L, Mattheus U, Neckel PH, Mack AF, Bolz S, Ueffing M, Pashkovskaia N, Achberger K, Liebau S. A Cleared View on Retinal Organoids. Cells. 2019 Apr 28. Epub 2019/05/01. doi: 10.3390/cells8050391. PubMed PMID: 31035373.
  4. Fischer MD, Ochakovski GA, Beier B, Seitz IP, Vaheb Y, Kortuem C, Reichel FFL, Kuehlewein L, Kahle NA, Peters T, Girach A, Zrenner E, Ueffing M, MacLaren RE, Bartz-Schmidt KU, Wilhelm B. Efficacy and Safety of Retinal Gene Therapy Using Adeno-Associated Virus Vector for Patients With Choroideremia: A Randomized Clinical Trial. JAMA Ophthalmol. 2019 Aug 29. Epub 2019/08/30. doi: 10.1001/jamaophthalmol.2019.3278. PubMed PMID: 31465092.
  5. Handa JT, Bowes Rickman C, Dick AD, Gorin MB, Miller JW, Toth CA, Ueffing M, Zarbin M, Farrer LA. A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration. Nature communications. 2019 Jul 26. Epub 2019/07/28. doi: 10.1038/s41467-019-11262-1. PubMed PMID: 31350409.
  6. Kersten E, Dammeier S, Ajana S, Groenewoud JMM, Codrea M, Klose F, Lechanteur YT, Fauser S, Ueffing M, Delcourt C, Hoyng CB, de Jong EK, den Hollander AI, Consortium E-R. Metabolomics in serum of patients with non-advanced age-related macular degeneration reveals aberrations in the glutamine pathway. PloS one. 2019 Epub 2019/06/21. doi: 10.1371/journal.pone.0218457. PubMed PMID: 31220133.
  7. Knapp B, Roedig J, Boldt K, Krzysko J, Horn N, Ueffing M, Wolfrum U. Affinity proteomics identifies novel functional modules related to adhesion GPCRs. Ann N Y Acad Sci. 2019 Nov. Epub 2019/08/24. doi: 10.1111/nyas.14220. PubMed PMID: 31441075.
  8. Lauer J, Segeletz S, Cezanne A, Guaitoli G, Raimondi F, Gentzel M, Alva V, Habeck M, Kalaidzidis Y, Ueffing M, Lupas AN, Gloeckner CJ, Zerial M. Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding. Elife. 2019 Nov 13. Epub 2019/11/14. doi: 10.7554/eLife.46302. PubMed PMID: 31718772.
  9. Rachev E, Schuster-Gossler K, Fuhl F, Ott T, Tveriakhina L, Beckers A, Hegermann J, Boldt K, Mai M, Kremmer E, Ueffing M, Blum M, Gossler A. CFAP43 modulates ciliary beating in mouse and Xenopus. Dev Biol. 2019 Dec 27. Epub 2019/12/31. doi: 10.1016/j.ydbio.2019.12.010. PubMed PMID: 31884020.
  10. Samardzija M, Masarini K, Ueffing M, Trifunovic D. HDAC Inhibition Prevents Primary Cone Degeneration Even After the Onset of Degeneration. Adv Exp Med Biol. 2019 Epub 2019/12/31. doi: 10.1007/978-3-030-27378-1_63. PubMed PMID: 31884642.
  11. Stingl KT, Kuehlewein L, Weisschuh N, Biskup S, Cremers FPM, Khan MI, Kelbsch C, Peters T, Ueffing M, Wilhelm B, Zrenner E, Stingl K. Chromatic Full-Field Stimulus Threshold and Pupillography as Functional Markers for Late-Stage, Early-Onset Retinitis Pigmentosa Caused by CRB1 Mutations. Transl Vis Sci Technol. 2019 Nov. Epub 2019/12/28. doi: 10.1167/tvst.8.6.45. PubMed PMID: 31879567.
  12. van Dam TJP, Kennedy J, van der Lee R, de Vrieze E, Wunderlich KA, Rix S, Dougherty GW, Lambacher NJ, Li C, Jensen VL, Leroux MR, Hjeij R, Horn N, Texier Y, Wissinger Y, van Reeuwijk J, Wheway G, Knapp B, Scheel JF, Franco B, Mans DA, van Wijk E, Kepes F, Slaats GG, Toedt G, Kremer H, Omran H, Szymanska K, Koutroumpas K, Ueffing M, Nguyen TT, Letteboer SJF, Oud MM, van Beersum SEC, Schmidts M, Beales PL, Lu Q, Giles RH, Szklarczyk R, Russell RB, Gibson TJ, Johnson CA, Blacque OE, Wolfrum U, Boldt K, Roepman R, Hernandez-Hernandez V, Huynen MA. CiliaCarta: An integrated and validated compendium of ciliary genes. PloS one. 2019 Epub 2019/05/17. doi: 10.1371/journal.pone.0216705. PubMed PMID: 31095607.

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2018

  1. Dammeier S, Martus P, Klose F, Seid M, Bosch D, D‘Alvise J, Ziemssen F, Dimopoulos S, Ueffing M. Combined Targeted Analysis of Metabolites and Proteins in Tear Fluid With Regard to Clinical Applications. Translational Vision Science & Technology. 2018. doi: 10.1167/tvst.7.6.22.
  2. Balta EA, Schaffner I, Wittmann MT, Sock E, von Zweydorf F, von Wittgenstein J, Steib K, Heim B, Kremmer E, Haberle BM, Ueffing M, Lie DC, Gloeckner CJ. Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis. Sci Rep. 2018 Nov 1. Epub 2018/11/06. doi: 10.1038/s41598-018-34480-x. PubMed PMID: 30385877.
  3. Beckers A, Ott T, Schuster-Gossler K, Boldt K, Alten L, Ueffing M, Blum M, Gossler A. The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice. Sci Rep. 2018 Oct 2. Epub 2018/10/04. doi: 10.1038/s41598-018-33045-2. PubMed PMID: 30279523.
  4. Beyer T, Bolz S, Junger K, Horn N, Moniruzzaman M, Wissinger Y, Ueffing M, Boldt K. CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement. Molecular & cellular proteomics : MCP. 2018 Jul. Epub 2018/04/05. doi: 10.1074/mcp.RA117.000487. PubMed PMID: 29615496.
  5. Falk N, Kessler K, Schramm SF, Boldt K, Becirovic E, Michalakis S, Regus-Leidig H, Noegel AA, Ueffing M, Thiel CT, Roepman R, Brandstatter JH, Giessl A. Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis. J Cell Sci. 2018 Aug 17. Epub 2018/07/29. doi: 10.1242/jcs.218487. PubMed PMID: 30054381.
  6. Fischer MD, Ochakovski GA, Beier B, Seitz IP, Vaheb Y, Kortuem C, Reichel FFL, Kuehlewein L, Kahle NA, Peters T, Girach A, Zrenner E, Ueffing M, MacLaren RE, Bartz-Schmidt K, Wilhelm B. Changes in Retinal Sensitivity after Gene Therapy in Choroideremia. Retina. 2018 Oct 9. Epub 2018/10/12. doi: 10.1097/IAE.0000000000002360. PubMed PMID: 30308560.
  7. Hartill VL, van de Hoek G, Patel MP, Little R, Watson CM, Berry IR, Shoemark A, Abdelmottaleb D, Parkes E, Bacchelli C, Szymanska K, Knoers NV, Scambler PJ, Ueffing M, Boldt K, Yates R, Winyard PJ, Adler B, Moya E, Hattingh L, Shenoy A, Hogg C, Sheridan E, Roepman R, Norris D, Mitchison HM, Giles RH, Johnson CA. DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport. Human molecular genetics. 2018 Feb 1. Epub 2017/12/12. doi: 10.1093/hmg/ddx422. PubMed PMID: 29228333.
  8. Kahle NA, Peters T, Zobor D, Kuehlewein L, Kohl S, Zhour A, Werner A, Seitz IP, Sothilingam V, Michalakis S, Biel M, Ueffing M, Zrenner E, Bartz-Schmidt KU, Fischer MD, Wilhelm BJC. Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial. Hum Gene Ther Clin Dev. 2018 Sep. Epub 2018/09/07. doi: 10.1089/humc.2018.088. PubMed PMID: 30187779.
  9. Kersten E, Paun CC, Schellevis RL, Hoyng CB, Delcourt C, Lengyel I, Peto T, Ueffing M, Klaver CCW, Dammeier S, den Hollander AI, de Jong EK. Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration. Surv Ophthalmol. 2018 Jan - Feb. Epub 2017/05/20. doi: 10.1016/j.survophthal.2017.05.003. PubMed PMID: 28522341.
  10. Reichel FF, Peters T, Wilhelm B, Biel M, Ueffing M, Wissinger B, Bartz-Schmidt KU, Klein R, Michalakis S, Fischer MD, Consortium R-C. Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients. Investigative ophthalmology & visual science. 2018 Apr 1. Epub 2018/04/21. doi: 10.1167/iovs.17-22494. PubMed PMID: 29677353.
  11. Trifunovic D, Petridou E, Comitato A, Marigo V, Ueffing M, Paquet-Durand F. Primary Rod and Cone Degeneration Is Prevented by HDAC Inhibition. Adv Exp Med Biol. 2018 Epub 2018/05/04. doi: 10.1007/978-3-319-75402-4_45. PubMed PMID: 29721965.
  12. van Leeuwen EM, Emri E, Merle BMJ, Colijn JM, Kersten E, Cougnard-Gregoire A, Dammeier S, Meester-Smoor M, Pool FM, de Jong EK, Delcourt C, Rodrigez-Bocanegra E, Biarnes M, Luthert PJ, Ueffing M, Klaver CCW, Nogoceke E, den Hollander AI, Lengyel I. A new perspective on lipid research in age-related macular degeneration. Prog Retin Eye Res. 2018 Nov. Epub 2018/05/08. doi: 10.1016/j.preteyeres.2018.04.006. PubMed PMID: 29729972.
  13. Vighi E, Trifunovic D, Veiga-Crespo P, Rentsch A, Hoffmann D, Sahaboglu A, Strasser T, Kulkarni M, Bertolotti E, van den Heuvel A, Peters T, Reijerkerk A, Euler T, Ueffing M, Schwede F, Genieser HG, Gaillard P, Marigo V, Ekstrom P, Paquet-Durand F. Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration. Proc Natl Acad Sci U S A. 2018 Mar 27. Epub 2018/03/14. doi: 10.1073/pnas.1718792115. PubMed PMID: 29531030.
  14. Ying G, Boldt K, Ueffing M, Gerstner CD, Frederick JM, Baehr W. The small GTPase RAB28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium. J Biol Chem. 2018 Nov 9. Epub 2018/09/20. doi: 10.1074/jbc.RA118.005484. PubMed PMID: 30228185.

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2017

  1. Reichel FF, Dauletbekov DL, Klein R, Peters T, Ochakovski GA, Seitz IP, Wilhelm B, Ueffing M, Biel M, Wissinger B, Michalakis S, Bartz-Schmidt KU, Fischer MD, Consortium R-C. AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye. Mol Ther. 2017 Dec 6. Epub 2017/10/04. doi: 10.1016/j.ymthe.2017.08.018. PubMed PMID: 28970046.
  2. Tikidji-Hamburyan A, Reinhard K, Storchi R, Dietter J, Seitter H, Davis KE, Idrees S, Mutter M, Walmsley L, Bedford RA, Ueffing M, Ala-Laurila P, Brown TM, Lucas RJ, Munch TA. Rods progressively escape saturation to drive visual responses in daylight conditions. Nature communications. 2017 Nov 27. Epub 2017/11/29. doi: 10.1038/s41467-017-01816-6. PubMed PMID: 29180667.
  3. Seitz IP, Michalakis S, Wilhelm B, Reichel FF, Ochakovski GA, Zrenner E, Ueffing M, Biel M, Wissinger B, Bartz-Schmidt KU, Peters T, Fischer MD, Consortium R-C. Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates. Investigative ophthalmology & visual science. 2017 Nov 1. Epub 2017/11/09. doi: 10.1167/iovs.17-22473. PubMed PMID: 29117317.
  4. Wills ES, Te Morsche RHM, van Reeuwijk J, Horn N, Geomini I, van de Laarschot LFM, Mans DA, Ueffing M, Boldt K, Drenth JPH, Roepman R. Liver cyst gene knockout in cholangiocytes inhibits cilium formation and Wnt signaling. Human molecular genetics. 2017 Nov 1. Epub 2017/10/04. doi: 10.1093/hmg/ddx308. PubMed PMID: 28973524.
  5. Stauber M, Boldt K, Wrede C, Weidemann M, Kellner M, Schuster-Gossler K, Kuhnel MP, Hegermann J, Ueffing M, Gossler A. 1700012B09Rik, a FOXJ1 effector gene active in ciliated tissues of the mouse but not essential for motile ciliogenesis. Dev Biol. 2017 Sep 1. Epub 2017/07/02. doi: 10.1016/j.ydbio.2017.06.027. PubMed PMID: 28666954.
  6. Clin L, Leitritz MA, Dietter J, Dynowski M, Burgert O, Ueffing M, Thies C. Design, Implementation and Operation of a Reading Center Platform for Clinical Studies. Stud Health Technol Inform. 2017 Epub 2017/04/21. PubMed PMID: 28423750.
  7. Straubinger J, Boldt K, Kuret A, Deng L, Krattenmacher D, Bork N, Desch M, Feil R, Feil S, Nemer M, Ueffing M, Ruth P, Just S, Lukowski R. Amplified pathogenic actions of angiotensin II in cysteine-rich LIM-only protein 4-negative mouse hearts. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017 Apr. Epub 2017/02/01. doi: 10.1096/fj.201601186. PubMed PMID: 28138039.
  8. Degroote RL, Uhl PB, Amann B, Krackhardt AM, Ueffing M, Hauck SM, Deeg CA. Formin like 1 expression is increased on CD4+ T lymphocytes in spontaneous autoimmune uveitis. J Proteomics. 2017 Feb 10. Epub 2017/01/07. doi: 10.1016/j.jprot.2016.12.015. PubMed PMID: 28057602.

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2016

  1. Trifunović D, Arango-Gonzalez B, Comitato A, Barth M, Del Amo EM, Kulkarni M, Sahaboglu A, Hauck SM, Urtti A, Arsenijevic Y, Ueffing M, Marigo V, Paquet-Durand F. HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo. Hum Mol Genet. 2016 Aug 15. pii: ddw275. [Epub ahead of print] PubMed PMID: 27530254.
  2. Kortvely E, Hauck SM, Behler J, Ho N, Ueffing M. The unconventional secretion of ARMS2. Hum Mol Genet. 2016 Jun 6. pii: ddw162. [Epub ahead of print] PubMed PMID: 27270414.
  3. Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R; UK10K Rare Diseases Group. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016 May 13;7:11491. doi: 10.1038/ncomms11491. PubMed PMID: 27173435; PubMed Central PMCID: PMC4869170.
  4. Valdés J, Trachsel-Moncho L, Sahaboglu A, Trifunović D, Miranda M, Ueffing M, Paquet-Durand F, Schmachtenberg O. Organotypic retinal explant cultures as in vitro alternative for diabetic retinopathy studies. ALTEX. 2016 May 9. doi: 10.14573/altex.1603111. [Epub ahead of print] PubMed PMID: 27159027.
  5. Ly A, Merl-Pham J, Priller M, Gruhn F, Senninger N, Ueffing M, Hauck SM. Proteomic Profiling Suggests Central Role Of STAT Signaling during Retinal Degeneration in the rd10 Mouse Model. J Proteome Res. 2016 Apr 1;15(4):1350-9. doi: 10.1021/acs.jproteome.6b00111. Epub 2016 Mar 14. PubMed PMID: 26939627.
  6. Ivanov IV, Leitritz MA, Norrenberg LA, Völker M, Dynowski M, Ueffing M, Dietter J. Human Vision-Motivated Algorithm Allows Consistent Retinal Vessel Classification Based on Local Color Contrast for Advancing General Diagnostic Exams. Invest Ophthalmol Vis Sci. 2016 Feb;57(2):731-8. doi: 10.1167/iovs.15-17831. PubMed PMID: 26906159.
  7. Schultheiss M, Schnichels S, Hermann T, Hurst J, Feldkaemper M, Arango-Gonzalez B, Ueffing M, Bartz-Schmidt KU, Zeck G, Spitzer MS. Hypothermia Protects and Prolongs the Tolerance Time of Retinal Ganglion Cells against Ischemia. PLoS One. 2016 Feb 5;11(2):e0148616. doi: 10.1371/journal.pone.0148616. eCollection 2016. PubMed PMID: 26848953; PubMed Central PMCID: PMC4744055.
  8. Sanders AA, de Vrieze E, Alazami AM, Alzahrani F, Malarkey EB, Sorusch N, Tebbe L, Kuhns S, van Dam TJ, Alhashem A, Tabarki B, Lu Q, Lambacher NJ, Kennedy JE, Bowie RV, Hetterschijt L, van Beersum S, van Reeuwijk J, Boldt K, Kremer H, Kesterson RA, Monies D, Abouelhoda M, Roepman R, Huynen MH, Ueffing M, Russell RB, Wolfrum U, Yoder BK, van Wijk E, Alkuraya FS, Blacque OE. KIAA0556 is a novel ciliary basal body component mutated in Joubert syndrome. Genome Biol. 2015 Dec 29;16:293. doi: 10.1186/s13059-015-0858-z. PubMed PMID: 26714646; PubMed Central PMCID: PMC4699358.
  9. Oroszlán G, Kortvely E, Szakács D, Kocsis A, Dammeier S, Zeck A, Ueffing M, Závodszky P, Pál G, Gál P, Dobó J. MASP-1 and MASP-2 Do Not Activate Pro-Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors. J Immunol. 2016 Jan 15;196(2):857-65. doi: 10.4049/jimmunol.1501717. Epub 2015 Dec 16. PubMed PMID: 26673137.
  10. Dammeier S, Nahnsen S, Veit J, Wehner F, Ueffing M, Kohlbacher O. Mass-Spectrometry-Based Proteomics Reveals Organ-Specific Expression Patterns To Be Used as Forensic Evidence. J Proteome Res. 2016 Jan 4;15(1):182-92. doi: 10.1021/acs.jproteome.5b00704. Epub 2015 Dec 8. PubMed PMID: 26593679.

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2015

  1. Bachmann-Gagescu R, Dona M, Hetterschijt L, Tonnaer E, Peters T, de Vrieze E, Mans DA, van Beersum SE, Phelps IG, Arts HH, Keunen JE, Ueffing M, Roepman R, Boldt K, Doherty D, Moens CB, Neuhauss SC, Kremer H, van Wijk E. The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking. PLoS Genet. 2015 Oct 20;11(10):e1005575. doi: 10.1371/journal.pgen.1005575. eCollection 2015 Oct. PubMed PMID: 26485645; PubMed Central PMCID: PMC4617701.
  2. Dona M, Bachmann-Gagescu R, Texier Y, Toedt G, Hetterschijt L, Tonnaer EL, Peters TA, van Beersum SE, Bergboer JG, Horn N, de Vrieze E, Slijkerman RW, van Reeuwijk J, Flik G, Keunen JE, Ueffing M, Gibson TJ, Roepman R, Boldt K, Kremer H, van Wijk E. NINL and DZANK1 Co-function in Vesicle Transport and Are Essential for Photoreceptor Development in Zebrafish. PLoS Genet. 2015 Oct 20;11(10):e1005574. doi: 10.1371/journal.pgen.1005574. eCollection 2015 Oct. PubMed PMID: 26485514; PubMed Central PMCID: PMC4617706.
  3. Wheway G, Schmidts M, Mans DA, Szymanska K, Nguyen TM, Racher H, Phelps IG, Toedt G, Kennedy J, Wunderlich KA, Sorusch N, Abdelhamed ZA, Natarajan S, Herridge W, van Reeuwijk J, Horn N, Boldt K, Parry DA, Letteboer SJ, Roosing S, Adams M, Bell SM, Bond J, Higgins J, Morrison EE, Tomlinson DC, Slaats GG, van Dam TJ, Huang L, Kessler K, Giessl A, Logan CV, Boyle EA, Shendure J, Anazi S, Aldahmesh M, Al Hazzaa S, Hegele RA, Ober C, Frosk P, Mhanni AA, Chodirker BN, Chudley AE, Lamont R, Bernier FP, Beaulieu CL, Gordon P, Pon RT, Donahue C, Barkovich AJ, Wolf L, Toomes C, Thiel CT, Boycott KM, McKibbin M, Inglehearn CF; UK10K Consortium; University of Washington Center for Mendelian Genomics, Stewart F, Omran H, Huynen MA, Sergouniotis PI, Alkuraya FS, Parboosingh JS, Innes AM, Willoughby CE, Giles RH, Webster AR, Ueffing M, Blacque O, Gleeson JG, Wolfrum U, Beales PL, Gibson T, Doherty D, Mitchison HM, Roepman R, Johnson CA. An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes. Nat Cell Biol. 2015 Aug;17(8):1074-87. doi: 10.1038/ncb3201. Epub 2015 Jul 13.
  4. Schaefer A, Neschen S, Kahle M, Sarioglu H, Gaisbauer T, Imhof A, Adamski J, Hauck SM, Ueffing M. The Epoxyeicosatrienoic Acid Pathway Enhances Hepatic Insulin Signaling and Is Repressed in Insulin-Resistant Mouse Liver. Mol Cell Proteomics. 2015 Jun 12. pii: mcp.M115.049064. [Epub ahead of print]
  5. Schmidts M, Hou Y, Cortés CR, Mans DA, Huber C, Boldt K, Patel M, van Reeuwijk J, Plaza JM, van Beersum SE, Yap ZM, Letteboer SJ, Taylor SP, Herridge W, Johnson CA, Scambler PJ, Ueffing M, Kayserili H, Krakow D, King SM; UK10K, Beales PL, Al-Gazali L, Wicking C, Cormier-Daire V, Roepman R, Mitchison HM, Witman GB. TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport. Nat Commun. 2015 Jun 5;6:7074. doi: 10.1038/ncomms8074
  6. Benmerah A, Durand B, Giles RH, Harris T, Kohl L, Laclef C, Meilhac SM, Mitchison HM, Pedersen LB, Roepman R, Swoboda P, Ueffing M, Bastin P. The more we know, the more we have to discover: an exciting future for understanding cilia and ciliopathies. Cilia. 2015 Mar 31;4:5. doi: 10.1186/s13630-015-0014-0. eCollection 2015
  7. Agca C, Boldt K, Gubler A, Meneau I, Corpet A, Samardzija M, Stucki M, Ueffing M, Grimm C. Expression of leukemia inhibitory factor in Müller glia cells is regulated by a redox-dependent mRNA stability mechanism. BMC Biol. 2015 Apr 25;13:30. doi: 10.1186/s12915-015-0137-1.
  8. Seitz IP, Zhour A, Kohl S, Llavona P, Peter T, Wilhelm B, Zrenner E, Ueffing M, Bartz-Schmidt KU, Fischer MD. Multimodal assessment of choroideremia patients defines pre-treatment characteristics. Graefes Arch Clin Exp Ophthalmol. 2015 Mar 7. [Epub ahead of print]
  9. Kahle M, Schäfer A, Seelig A, Schultheiß J, Wu M, Aichler M, Leonhardt J, Rathkolb B, Rozman J, Sarioglu H, Hauck SM, Ueffing M, Wolf E, Kastenmueller G, Adamski J, Walch A, Hrabé de Angelis M, Neschen S. High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice. Mol Metab. 2014 Nov 14;4(1):39-50. doi: 10.1016/j.molmet.2014.11.004. eCollection 2015 Jan.
  10. Porras P, Duesbury M, Fabregat A, Ueffing M, Orchard S, Gloeckner CJ, Hermjakob H. A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology. Proteomics. 2015 Apr;15(8):1390-404. doi: 10.1002/pmic.201400390. Epub 2015 Mar 21.
  11. Thompson RB, Reffatto V, Bundy JG, Kortvely E, Flinn JM, Lanzirotti A, Jones EA, McPhail DS, Fearn S, Boldt K, Ueffing M, Ratu SG, Pauleikhoff L, Bird AC, Lengyel I. Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1565-70. doi: 10.1073/pnas.1413347112. Epub 2015 Jan 20. Erratum in: Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3971.
  12. Azimzadeh O, Sievert W, Sarioglu H, Merl-Pham J, Yentrapalli R, Bakshi MV, Janik D, Ueffing M, Atkinson MJ, Multhoff G, Tapio S. Integrative proteomics and targeted transcriptomics analyses in cardiac endothelial cells unravel mechanisms of long-term radiation-induced vascular dysfunction. J Proteome Res. 2015 Feb 6;14(2):1203-19. doi: 10.1021/pr501141b. Epub 2015 Jan 29.

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2014

  1. Ly A, Schöne C, Becker M, Rattke J, Meding S, Aichler M, Suckau D, Walch A, Hauck SM, Ueffing M. High-resolution MALDI mass spectrometric imaging of lipids in the mammalian retina. Histochem Cell Biol. 2015 May;143(5):453-62. doi: 10.1007/s00418-014-1303-1. Epub 2014 Dec 23.
  2. Kempf SJ, Casciati A, Buratovic S, Janik D, von Toerne C, Ueffing M, Neff F, Moertl S, Stenerlöw B, Saran A, Atkinson MJ, Eriksson P, Pazzaglia S, Tapio S. The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation. Mol Neurodegener. 2014 Dec 16;9:57. doi: 10.1186/1750-1326-9-57.
  3. Arango-Gonzalez B, Trifunović D, Sahaboglu A, Kranz K, Michalakis S, Farinelli P, Koch S, Koch F, Cottet S, Janssen-Bienhold U, Dedek K, Biel M, Zrenner E, Euler T, Ekström P, Ueffing M, Paquet-Durand F. Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration. PLoS One. 2014 Nov 13;9(11):e112142. doi: 10.1371/journal.pone.0112142. eCollection 2014
  4. Sabag AD, Smolkin T, Mumblat Y, Ueffing M, Kessler O, Gloeckner CJ, Neufeld G. The role of the plexin-A2 receptor in Sema3A and Sema3B signal transduction. J Cell Sci. 2014 Dec 15;127(24):5240-52. doi: 10.1242/jcs.155960. Epub 2014 Oct 21.
  5. Zahedi RP, Ueffing M, Sickmann A. Proteomics--moving from inventory to personalized medicine? Proteomics. 2014 Sep;14(17-18):1953. doi: 10.1002/pmic.201470133. No abstract available.
  6. Boldt K, Gloeckner CJ, Texier Y, von Zweydorf F, Ueffing M. Applying SILAC for the differential analysis of protein complexes. Methods Mol Biol. 2014;1188:177-90. doi: 10.1007/978-1-4939-1142-4_13.
  7. Roosing S, Lamers IJ, de Vrieze E, van den Born LI, Lambertus S, Arts HH; POC1B Study Group, Peters TA, Hoyng CB, Kremer H, Hetterschijt L, Letteboer SJ, van Wijk E, Roepman R, den Hollander AI, Cremers FP. Disruption of the basal body protein POC1B results in autosomal-recessive cone-rod dystrophy. Am J Hum Genet. 2014 Aug 7;95(2):131-42. doi: 10.1016/j.ajhg.2014.06.012. Epub 2014 Jul 10.
  8. Becirovic E, Nguyen ON, Paparizos C, Butz ES, Stern-Schneider G, Wolfrum U, Hauck SM, Ueffing M, Wahl-Schott C, Michalakis S, Biel M. Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors. Hum Mol Genet. 2014 Nov 15;23(22):5989-97. doi: 10.1093/hmg/ddu323. Epub 2014 Jun 24
  9. Ekström PA, Ueffing M, Zrenner E, Paquet-Durand F. Novel in situ activity assays for the quantitative molecular analysis of neurodegenerative processes in the retina. Curr Med Chem. 2014;21(30):3478-93. Review.
  10. von Toerne C, Menzler J, Ly A, Senninger N, Ueffing M, Hauck SM. Identification of a novel neurotrophic factor from primary retinal Müller cells using stable isotope labeling by amino acids in cell culture (SILAC). Mol Cell Proteomics. 2014 Sep;13(9):2371-81. doi: 10.1074/mcp.M113.033613. Epub 2014 Jun 12.
  11. Grabe HJ, Assel H, Bahls T, Dörr M, Endlich K, Endlich N, Erdmann P, Ewert R, Felix SB, Fiene B, Fischer T, Flessa S, Friedrich N, Gadebusch-Bondio M, Salazar MG, Hammer E, Haring R, Havemann C, Hecker M, Hoffmann W, Holtfreter B, Kacprowski T, Klein K, Kocher T, Kock H, Krafczyk J, Kuhn J, Langanke M, Lendeckel U, Lerch MM, Lieb W, Lorbeer R, Mayerle J, Meissner K, zu Schwabedissen HM, Nauck M, Ott K, Rathmann W, Rettig R, Richardt C, Saljé K, Schminke U, Schulz A, Schwab M, Siegmund W, Stracke S, Suhre K, Ueffing M, Ungerer S, Völker U, Völzke H, Wallaschofski H, Werner V, Zygmunt MT, Kroemer HK. Cohort profile: Greifswald approach to individualized medicine (GANI_MED). J Transl Med. 2014 May 23;12:144. doi: 10.1186/1479-5876-12-144.
  12. Sahaboglu A, Tanimoto N, Bolz S, Garrido MG, Ueffing M, Seeliger MW, Löwenheim H, Ekström P, Paquet-Durand F. Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptors. Cell Death Dis. 2014 May 22;5:e1234. doi: 10.1038/cddis.2014.208.
  13. Sacco F, Boldt K, Calderone A, Panni S, Paoluzi S, Castagnoli L, Ueffing M, Cesareni G. Combining affinity proteomics and network context to identify new phosphatase substrates and adapters in growth pathways. Front Genet. 2014 May 7;5:115. doi: 10.3389/fgene.2014.00115. eCollection 2014.
  14. Klar R, Schober S, Rami M, Mall S, Merl J, Hauck SM, Ueffing M, Admon A, Slotta-Huspenina J, Schwaiger M, Stevanović S, Oostendorp RA, Busch DH, Peschel C, Krackhardt AM. Therapeutic targeting of naturally presented myeloperoxidase-derived HLA peptide ligands in myeloid leukemia cells by TCR-transgenic T cells. Leukemia. 2014 Apr 16. doi: 10.1038/leu.2014.131. [Epub ahead of print] PubMed PMID: 24736212.
  15. Piccoli G, Onofri F, Cirnaru MD, Kaiser CJ, Jagtap P, Kastenmüller A, Pischedda F, Marte A, von Zweydorf F, Vogt A, Giesert F, Pan L, Antonucci F, Kiel C, Zhang M, Weinkauf S, Sattler M, Sala C, Matteoli M, Ueffing M, Gloeckner CJ. LRRK2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain. Mol Cell Biol. 2014 Mar 31. [Epub ahead of print] PubMed PMID: 24687852.
  16. Paquet-Durand F, Sahaboglu A, Dietter J, Paquet-Durand O, Hitzmann B, Ueffing M, Ekström PA. How long does a photoreceptor cell take to die? Implications for the causative cell death mechanisms. Adv Exp Med Biol. 2014;801:575-81. doi: 10.1007/978-1-4614-3209-8_73. PubMed PMID: 24664746.
  17. Sahaboglu A, Bolz S, Löwenheim H, Paquet-Durand F. Expression of Poly(ADP-Ribose) Glycohydrolase in Wild-Type and PARG-110 Knock-Out Retina. Adv Exp Med Biol. 2014;801:463-9. doi: 10.1007/978-1-4614-3209-8_59. PubMed PMID: 24664732.
  18. Hauck SM, von Toerne C, Ueffing M. The neuroprotective potential of retinal müller glial cells. Adv Exp Med Biol. 2014;801:381-7. doi: 10.1007/978-1-4614-3209-8_48. PubMed PMID: 24664721.
  19. Langmann T, Ueffing M, Kirchhof B, Holz FG, Pauleikhoff D. [In Process Citation]. Klin Monbl Augenheilkd. 2014 Mar;231(3):266-8. doi: 10.1055/s-0033-1360359. Epub 2014 Mar 21. German. PubMed PMID: 24658865.
  20. Arango-Gonzalez B, Leitritz MA, Fischer D, Gerberding M, Paquet-Durand F, Ueffing M. [Current therapeutic approaches in inherited retinal degeneration: from genes to chip]. Klin Monbl Augenheilkd. 2014 Mar;231(3):222-31. doi: 10.1055/s-0033-1360259. Epub 2014 Mar 21. German. PubMed PMID: 24658859.
  21. Degroote RL, Hauck SM, Amann B, Hirmer S, Ueffing M, Deeg CA. Unraveling the equine lymphocyte proteome: differential septin 7 expression associates with immune cells in equine recurrent uveitis. PLoS One. 2014 Mar 10;9(3):e91684. doi: 10.1371/journal.pone.0091684. eCollection 2014. PubMed PMID: 24614191; PubMed Central PMCID: PMC3951111.
  22. Kucharska J, Del Río P, Arango-Gonzalez B, Gorza M, Feuchtinger A, Hauck SM, Ueffing M. Cyr61 activates retinal cells and prolongs photoreceptor survival in rd1 mouse model of retinitis pigmentosa. J Neurochem. 2014 Mar 4. doi: 10.1111/jnc.12704. [Epub ahead of print] PubMed PMID: 24593181.
  23. Texier Y, Toedt G, Gorza M, Mans DA, van Reeuwijk J, Horn N, Willer J, Katsanis N, Roepman R, Gibson TJ, Ueffing M, Boldt K. Elution Profile Analysis of SDS-induced Subcomplexes by Quantitative Mass Spectrometry. Mol Cell Proteomics. 2014 May;13(5):1382-91. doi: 10.1074/mcp.O113.033233. Epub 2014 Feb 21. PubMed PMID: 24563533.
  24. Griciuc A, Roux MJ, Merl J, Giangrande A, Hauck SM, Aron L, Ueffing M. Proteomic survey reveals altered energetic patterns and metabolic failure prior to retinal degeneration. J Neurosci. 2014 Feb 19;34(8):2797-812. doi: 10.1523/JNEUROSCI.2982-13.2014. PubMed PMID: 24553922.
  25. Sun N, Ly A, Meding S, Witting M, Hauck SM, Ueffing M, Schmitt-Kopplin P, Aichler M, Walch A. High-resolution metabolite imaging of light and dark treated retina using MALDI-FTICR mass spectrometry. Proteomics. 2014 Apr;14(7-8):913-23. doi: 10.1002/pmic.201300407. PubMed PMID: 24459044.
  26. Pischedda F, Szczurkowska J, Cirnaru MD, Giesert F, Vezzoli E, Ueffing M, Sala C, Francolini M, Hauck SM, Cancedda L, Piccoli G. A cell surface biotinylation assay to reveal membrane-associated neuronal cues: Negr1 regulates dendritic arborization. Mol Cell Proteomics. 2014 Mar;13(3):733-48. doi: 10.1074/mcp.M113.031716. Epub 2013 Dec 31. PubMed PMID: 24382801; PubMed Central PMCID: PMC3945905.
  27. Muda K, Bertinetti D, Gesellchen F, Hermann JS, von Zweydorf F, Geerlof A, Jacob A, Ueffing M, Gloeckner CJ, Herberg FW. Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E34-43. doi: 10.1073/pnas.1312701111. Epub 2013 Dec 18. PubMed PMID: 24351927; PubMed Central PMCID: PMC3890784.
  28. Amann B, Hirmer S, Hauck SM, Kremmer E, Ueffing M, Deeg CA. True blue: S-opsin is widely expressed in different animal species. J Anim Physiol Anim Nutr (Berl). 2014 Feb;98(1):32-42. doi: 10.1111/jpn.12016. Epub 2012 Nov 22. PubMed PMID: 23173557.

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2013

  1. Ly A, Scheerer MF, Zukunft S, Muschet C, Merl J, Adamski J, Hrabě de Angelis M, Neschen S, Hauck SM, Ueffing M. Retinal proteome alterations in a mouse model of type 2 diabetes. Diabetologia. 2013 Sep 29. [Epub ahead of print] PubMed PMID: 24078137.
  2. Merl J, Deeg CA, Swadzba ME, Ueffing M, Hauck SM. Identification of autoantigens in body fluids by combining pull-downs and organic precipitations of intact immune complexes with quantitative label-free mass spectrometry. J Proteome Res. 2013 Sep 23. [Epub ahead of print] PubMed PMID: 24059262.
  3. Ly-Verdú S, Schaefer A, Kahle M, Groeger T, Neschen S, Arteaga-Salas JM, Ueffing M, de Angelis MH, Zimmermann R. The impact of blood on liver metabolite profiling - a combined metabolomic and proteomic approach. Biomed Chromatogr. 2013 Aug 12. doi: 10.1002/bmc.3010. [Epub ahead of print] PubMed PMID: 23934789.
  4. Priglinger CS, Szober CM, Priglinger SG, Merl J, Euler KN, Kernt M, Gondi G, Behler J, Geerlof A, Kampik A, Ueffing M, Hauck SM. Galectin-3 induces clustering of CD147 and integrin-β1 transmembrane glycoprotein receptors on the RPE cell surface. PLoS One. 2013 Jul 29;8(7):e70011. doi: 10.1371/journal.pone.0070011. Print 2013. PubMed PMID: 23922889; PubMed Central PMCID: PMC3726584.
  5. Hoff S, Halbritter J, Epting D, Frank V, Nguyen TM, van Reeuwijk J, Boehlke C, Schell C, Yasunaga T, Helmstädter M, Mergen M, Filhol E, Boldt K, Horn N, Ueffing M, Otto EA, Eisenberger T, Elting MW, van Wijk JA, Bockenhauer D, Sebire NJ, Rittig S, Vyberg M, Ring T, Pohl M, Pape L, Neuhaus TJ, Elshakhs NA, Koon SJ, Harris PC, Grahammer F, Huber TB, Kuehn EW, Kramer-Zucker A, Bolz HJ, Roepman R, Saunier S, Walz G, Hildebrandt F, Bergmann C, Lienkamp SS. ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3. Nat Genet. 2013 Aug;45(8):951-6. doi: 10.1038/ng.2681. Epub 2013 Jun 23. PubMed PMID: 23793029; PubMed Central PMCID: PMC3786259.
  6. Veiga-Crespo P, del Río P, Blindert M, Ueffing M, Hauck SM, Vecino E. Phenotypic map of porcine retinal ganglion cells. Mol Vis. 2013 Apr 16;19:904-16. Print 2013. PubMed PMID: 23687427; PubMed Central PMCID: PMC3654859.
  7. Wahl V, Vogler S, Grosche A, Pannicke T, Ueffing M, Wiedemann P, Reichenbach A, Hauck SM, Bringmann A. Osteopontin inhibits osmotic swelling of retinal glial (Müller) cells by inducing release of VEGF. Neuroscience. 2013 Aug 29;246:59-72. doi: 10.1016/j.neuroscience.2013.04.045. Epub 2013 Apr 30. PubMed PMID: 23639879.
  8. Sahaboglu A, Paquet-Durand O, Dietter J, Dengler K, Bernhard-Kurz S, Ekström PA, Hitzmann B, Ueffing M, Paquet-Durand F. Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanisms. Cell Death Dis. 2013 Feb 7;4:e488. doi: 10.1038/cddis.2013.12. PubMed PMID: 23392176; PubMed Central PMCID: PMC3593146.
  9. Fischer MD, Goldmann T, Wallrapp C, Mühlfriedel R, Beck SC, Stern-Schneider G, Ueffing M, Wolfrum U, Seeliger MW. Successful subretinal delivery and monitoring of MicroBeads in mice. PLoS One. 2013;8(1):e55173. doi: 10.1371/journal.pone.0055173. Epub 2013 Jan 28. PubMed PMID: 23383096; PubMed Central PMCID: PMC3557268.
  10. von Toerne C, Kahle M, Schäfer A, Ispiryan R, Blindert M, Hrabe De Angelis M, Neschen S, Ueffing M, Hauck SM. Apoe, Mbl2, and Psp plasma protein levels correlate with diabetic phenotype in NZO mice--an optimized rapid workflow for SRM-based quantification. J Proteome Res. 2013 Mar 1;12(3):1331-43. doi: 10.1021/pr3009836. Epub 2013 Feb 12. PubMed PMID: 23350727.
  11. Euler KN, Hauck SM, Ueffing M, Deeg CA. Bovine neonatal pancytopenia--comparative proteomic characterization of two BVD vaccines and the producer cell surface proteome (MDBK). BMC Vet Res. 2013 Jan 23;9:18. doi: 10.1186/1746-6148-9-18. PubMed PMID: 23343349; PubMed Central PMCID: PMC3560244.
  12. Gillardon F, Kremmer E, Froehlich T, Ueffing M, Hengerer B, Gloeckner CJ. ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2? J Neurosci Methods. 2013 Mar 30;214(1):62-8. doi: 10.1016/j.jneumeth.2012.12.015. Epub 2013 Jan 12.
  13. Vogt A, Fuerholzner B, Kinkl N, Boldt K, Ueffing M. Isotope coded protein labeling coupled immunoprecipitation (ICPL-IP): a novel approach for quantitative protein complex analysis from native tissue. Mol Cell Proteomics. 2013 May;12(5):1395-406. doi: 10.1074/mcp.O112.023648. Epub 2012 Dec 26. PubMed PMID: 23268931; PubMed Central PMCID: PMC3650347.
  14. Schiller C, Diakopoulos KN, Rohwedder I, Kremmer E, von Toerne C, Ueffing M, Weidle UH, Ohno H, Weiss EH. LST1 promotes the assembly of a molecular machinery responsible for tunneling nanotube formation. J Cell Sci. 2013 Feb 1;126(Pt 3):767-77. doi: 10.1242/jcs.114033. Epub 2012 Dec 13. PubMed PMID: 23239025.

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2012

  1. Amann B., Hirmer S., Hauck S. M., Kremmer E., Ueffing M., Deeg C. A.; True blue: S-opsin is widely expressed in different animal species; J.Anim.Physiol.Anim.Nutr.(Berl);  ;  
  2. Azimzadeh O., Scherthan H., Yentrapalli R., Barjaktarovic Z., Ueffing M., Conrad M., Neff F., Calzada-Wack J., Aubele M., Buske C., Atkinson M. J., Hauck S. M., Tapio S.; Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation; J.Proteomics; 75; 2384
  3. Barjaktarovic Z., Anastasov N., Azimzadeh O., Sriharshan A., Sarioglu H., Ueffing M., Tammio H., Hakanen A., Leszczynski D., Atkinson M. J., Tapio S.; Integrative proteomic and microRNA analysis of primary human coronary artery endothelial cells exposed to low-dose gamma radiation; Radiat.Environ.Biophys.;  EPub ahead of print;  
  4. Degroote R. L., Hauck S. M., Kremmer E., Amann B., Ueffing M., Deeg C. A.; Altered expression of talin 1 in peripheral immune cells points to a significant role of the innate immune system in spontaneous autoimmune uveitis; J.Proteomics; 75; 4536
  5. Dong G., Callegari E., Gloeckner C. J., Ueffing M., Wang H.; Mass spectrometric identification of novel posttranslational modification sites in Huntingtin; Proteomics; 12; 2060
  6. Dong G., Callegari E. A., Gloeckner C. J., Ueffing M., Wang H.; Prothymosin-alpha interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture; J.Biol.Chem.; 287; 1279
  7. Dong G., Gross K., Qiao F., Ferguson J., Callegari E. A., Rezvani K., Zhang D., Gloeckner C. J., Ueffing M., Wang H.; Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity; J.Neurochem.; 123; 437
  8. Elsner M., Rauser S., Maier S., Schone C., Balluff B., Meding S., Jung G., Nipp M., Sarioglu H., Maccarrone G., Aichler M., Feuchtinger A., Langer R., Jutting U., Feith M., Kuster B., Ueffing M., Zitzelsberger H., Hofler H., Walch A.; MALDI imaging mass spectrometry reveals COX7A2  TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma; J.Proteomics; 75; 4693
  9. Griciuc A., Aron L., Ueffing M.; Looking into eyes: rhodopsin pathologies in Drosophila; Adv.Exp.Med.Biol.; 723; 415
  10. Han Y., Yu G., Sarioglu H., Caballero-Martinez A., Schlott F., Ueffing M., Haase H., Peschel C., Krackhardt A. M.; Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity; J.Proteomics; 78C; 72
  11. Hauck S. M., Hofmaier F., Dietter J., Swadzba M. E., Blindert M., Amann B., Behler J., Kremmer E., Ueffing M., Deeg C. A.; Label-free LC-MSMS analysis of vitreous from autoimmune uveitis reveals a significant decrease in secreted Wnt signalling inhibitors DKK3 and SFRP2; J.Proteomics; 75; 4545
  12. Kortvely E., Ueffing M.; Common mechanisms for separate maculopathies?; Adv.Exp.Med.Biol.; 723; 61
  13. Meding S., Balluff B., Elsner M., Schone C., Rauser S., Nitsche U., Maak M., Schafer A., Hauck S. M., Ueffing M., Langer R., Hofler H., Friess H., Rosenberg R., Walch A.; Tissue-based proteomics reveals FXYD3  S100A11 and GSTM3 as novel markers for regional lymph node metastasis in colon cancer; J.Pathol.;  EPub ahead of print;  
  14. Merl J., Ueffing M., Hauck S. M., von Toerne C.; Direct comparison of MS-based label-free and SILAC quantitative proteome profiling strategies in primary retinal Muller cells; Proteomics; 12; 1902
  15. Nipp M., Elsner M., Balluff B., Meding S., Sarioglu H., Ueffing M., Rauser S., Unger K., Hofler H., Walch A., Zitzelsberger H.; S100-A10  thioredoxin  and S100-A6 as biomarkers of papillary thyroid carcinoma with lymph node metastasis identified by MALDI imaging; J.Mol.Med.(Berl); 90; 163
  16. Schafer A., von Toerne C., Becker S., Sarioglu H., Neschen S., Kahle M., Hauck S. M., Ueffing M.; Two-dimensional peptide separation improving sensitivity of selected reaction monitoring-based quantitative proteomics in mouse liver tissue: comparing off-gel electrophoresis and strong cation exchange chromatography; Anal.Chem.; 84; 8853
  17. Schiller C., Diakopoulos K. N., Rohwedder I., Kremmer E., von Toerne C., Ueffing M., Weidle U. H., Ohno H., Weiss E. H.; LST1 promotes the assembly of a molecular machinery responsible for tunneling nanotube formation; J.Cell.Sci.;  EPub ahead of print;  
  18. Schwarz A., Ueffing M., Deng Y., Gu X., Fattahi H., Metzger T., Ossiander M., Krausz F., Kienberger R.; Active stabilization for optically synchronized optical parametric chirped pulse amplification; Opt.Express; 20; 5557
  19. Sriharshan A., Boldt K., Sarioglu H., Barjaktarovic Z., Azimzadeh O., Hieber L., Zitzelsberger H., Ueffing M., Atkinson M. J., Tapio S.; Proteomic analysis by SILAC and 2D-DIGE reveals radiation-induced endothelial response: four key pathways; J.Proteomics; 75; 2319
  20. Szober C. M., Hauck S. M., Euler K. N., Frohlich K. J., Alge-Priglinger C., Ueffing M., Deeg C. A.; Profound re-organization of cell surface proteome in equine retinal pigment epithelial cells in response to in vitro culturing; Int.J.Mol.Sci.; 13; 14053
  21. Texier Y., Kinkl N., Boldt K., Ueffing M.; From quantitative protein complex analysis to disease mechanism; Vision Res.; 75; 108
  22. Trifunovic D., Sahaboglu A., Kaur J., Mencl S., Zrenner E., Ueffing M., Arango-Gonzalez B., Paquet-Durand F.; Neuroprotective strategies for the treatment of inherited photoreceptor degeneration; Curr.Mol.Med.; 12; 598
  23. Vogt A., Fuerholzner B., Kinkl N., Boldt K., Ueffing M.; ICPL-IP: A novel approach for quantitative protein complex analysis from native tissue; Mol.Cell.Proteomics;  EPub ahead of print;  
  24. Zipplies J. K., Hauck S. M., Eberhardt C., Hirmer S., Amann B., Stangassinger M., Ueffing M., Deeg C. A.; Miscellaneous vitreous-derived IgM antibodies target numerous retinal proteins in equine recurrent uveitis; Vet.Ophthalmol.; 15 Suppl 2; 57

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2011

  1. Balluff B., Rauser S., Meding S., Elsner M., Schone C., Feuchtinger A., Schuhmacher C., Novotny A., Jutting U., Maccarrone G., Sarioglu H., Ueffing M., Braselmann H., Zitzelsberger H., Schmid R. M., Hofler H., Ebert M. P., Walch A.; MALDI imaging identifies prognostic seven-protein signature of novel tissue markers in intestinal-type gastric cancer; Am.J.Pathol.; 179; 2720
  2. Boldt K., Mans D. A., Won J., van Reeuwijk J., Vogt A., Kinkl N., Letteboer S. J., Hicks W. L., Hurd R. E., Naggert J. K., Texier Y., den Hollander A. I., Koenekoop R. K., Bennett J., Cremers F. P., Gloeckner C. J., Nishina P. M., Roepman R., Ueffing M.; Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice; J.Clin.Invest.; 121; 2169
  3. Coene K. L., Mans D. A., Boldt K., Gloeckner C. J., van Reeuwijk J., Bolat E., Roosing S., Letteboer S. J., Peters T. A., Cremers F. P., Ueffing M., Roepman R.; The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase; Hum.Mol.Genet.; 20; 3592
  4. Del Rio P., Irmler M., Arango-Gonzalez B., Favor J., Bobe C., Bartsch U., Vecino E., Beckers J., Hauck S. M., Ueffing M.; GDNF-induced osteopontin from Muller glial cells promotes photoreceptor survival in the Pde6brd1 mouse model of retinal degeneration; Glia; 59; 821
  5. Griciuc A., Aron L., Ueffing M.; ER stress in retinal degeneration: a target for rational therapy?; Trends Mol.Med.; 17; 442
  6. Kiel C., Vogt A., Campagna A., Chatr-aryamontri A., Swiatek-de Lange M., Beer M., Bolz S., Mack A. F., Kinkl N., Cesareni G., Serrano L., Ueffing M.; Structural and functional protein network analyses predict novel signaling functions for rhodopsin; Mol.Syst.Biol.; 7; 551
  7. Meixner A., Boldt K., Van Troys M., Askenazi M., Gloeckner C. J., Bauer M., Marto J. A., Ampe C., Kinkl N., Ueffing M.; A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics; Mol.Cell.Proteomics; 10; M110.001172
  8. Piccoli G., Condliffe S. B., Bauer M., Giesert F., Boldt K., De Astis S., Meixner A., Sarioglu H., Vogt-Weisenhorn D. M., Wurst W., Gloeckner C. J., Matteoli M., Sala C., Ueffing M.; LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool; J.Neurosci.; 31; 2225
  9. Stanton C. M., Yates J. R., den Hollander A. I., Seddon J. M., Swaroop A., Stambolian D., Fauser S., Hoyng C., Yu Y., Atsuhiro K., Branham K., Othman M., Chen W., Kortvely E., Chalmers K., Hayward C., Moore A. T., Dhillon B., Ueffing M., Wright A. F.; Complement factor D in age-related macular degeneration; Invest.Ophthalmol.Vis.Sci.; 52; 8828
  10. Van Campenhout C. A., Eitelhuber A., Gloeckner C. J., Giallonardo P., Gegg M., Oller H., Grant S. G., Krappmann D., Ueffing M., Lickert H.; Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases; Dev.Cell.; 21; 479
  11. Webb K. J., Coolen M., Gloeckner C. J., Stigloher C., Bahn B., Topp S., Ueffing M., Bally-Cuif L.; The Enhancer of split transcription factor Her8a is a novel dimerisation partner for Her3 that controls anterior hindbrain neurogenesis in zebrafish; BMC Dev.Biol.; 11; 27
  12. Azimzadeh O, Scherthan H, Sarioglu H, Barjaktarovic Z, Conrad M, Vogt A, Calzada-Wack J, Neff F, Aubele M, Buske C, Atkinson MJ, Tapio S.; Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation.; Proteomics; 11; 3299
  13. Julien S, Peters T, Ziemssen F, Arango-Gonzalez B, Beck S, Thielecke H, Büth H, Van Vlierberghe S, Sirova M, Rossmann P, Rihova B, Schacht E, Dubruel P, Zrenner E, Schraermeyer U.; Implantation of ultrathin, biofunctionalized polyimide membranes into the subretinal space of rats.; Biomaterials; 32; 3890
  14. Schuettauf F, Stein T, Choragiewicz TJ, Rejdak R, Bolz S, Zurakowski D, Varde MA, Laties AM, Thaler S.; Caspase inhibitors protect against NMDA-mediated retinal ganglion cell death.; Clin Experiment Ophthalmol; 39; 545
    Kitiratschky VB, Glöckner CJ, Kohl S.; Mutation screening of the GUCA1B gene in patients with autosomal dominant cone and cone rod dystrophy.; Ophthalmic Genet; 32; 151
  15. Paquet-Durand F, Beck S, Michalakis S, Goldmann T, Huber G, Mühlfriedel R, Trifunović D, Fischer MD, Fahl E, Duetsch G, Becirovic E, Wolfrum U, van Veen T, Biel M, Tanimoto N, Seeliger MW.; A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa.; Hum Mol Genet; 20; 941
  16. Willmann G, Schäferhoff K, Fischer MD, Arango-Gonzalez B, Bolz S, Naycheva L, Röck T, Bonin M, Bartz-Schmidt KU, Zrenner E, Schatz A, Gekeler F.; Gene expression profiling of the retina after transcorneal electrical stimulation in wild-type Brown Norway rats.; Invest Ophthalmol Vis Sci; 52; 7529

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2010

  1. Gloeckner C. J., Boldt K., von Zweydorf F., Helm S., Wiesent L., Sarioglu H., Ueffing M.; Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2; J.Proteome Res.; 9; 1738
  2. Gloriam D. E., Orchard S., Bertinetti D., Bjorling E., Bongcam-Rudloff E., Borrebaeck C. A., Bourbeillon J., Bradbury A. R., de Daruvar A., Dubel S., Frank R., Gibson T. J., Gold L., Haslam N., Herberg F. W., Hiltke T., Hoheisel J. D., Kerrien S., Koegl M., Konthur Z., Korn B., Landegren U., Montecchi-Palazzi L., Palcy S., Rodriguez H., Schweinsberg S., Sievert V., Stoevesandt O., Taussig M. J., Ueffing M., Uhlen M., van der Maarel S., Wingren C., Woollard P., Sherman D. J., Hermjakob H.; A community standard format for the representation of protein affinity reagents; Mol.Cell.Proteomics; 9; 1
  3. Griciuc A., Aron L., Piccoli G., Ueffing M.; Clearance of Rhodopsin(P23H) aggregates requires the ERAD effector VCP; Biochim.Biophys.Acta; 1803; 424
  4. Griciuc A., Aron L., Roux M. J., Klein R., Giangrande A., Ueffing M.; Inactivation of VCP/ter94 suppresses retinal pathology caused by misfolded rhodopsin in Drosophila; PLoS Genet.; 6; 10.1371/journal.pgen.1001075
  5. Haebig K., Gloeckner C. J., Miralles M. G., Gillardon F., Schulte C., Riess O., Ueffing M., Biskup S., Bonin M.; ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2; PLoS One; 5; e13762
  6. Hauck S. M., Dietter J., Kramer R. L., Hofmaier F., Zipplies J. K., Amann B., Feuchtinger A., Deeg C. A., Ueffing M.; Deciphering membrane-associated molecular processes in target tissue of autoimmune uveitis by label-free quantitative mass spectrometry; Mol.Cell.Proteomics; 9; 2292
  7. Kinzel D., Boldt K., Davis E. E., Burtscher I., Trumbach D., Diplas B., Attie-Bitach T., Wurst W., Katsanis N., Ueffing M., Lickert H.; Pitchfork regulates primary cilia disassembly and left-right asymmetry; Dev.Cell.; 19; 66
  8. Kortvely E., Hauck S. M., Duetsch G., Gloeckner C. J., Kremmer E., Alge-Priglinger C. S., Deeg C. A., Ueffing M.; ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations; Invest.Ophthalmol.Vis.Sci.; 51; 79

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2009

  1. Apweiler R., Aslanidis C., Deufel T., Gerstner A., Hansen J., Hochstrasser D., Kellner R., Kubicek M., Lottspeich F., Maser E., Mewes H. W., Meyer H. E., Mullner S., Mutter W., Neumaier M., Nollau P., Nothwang H. G., Ponten F., Radbruch A., Reinert K., Rothe G., Stockinger H., Tarnok A., Taussig M. J., Thiel A., Thiery J., Ueffing M., Valet G., Vandekerckhove J., Verhuven W., Wagener C., Wagner O., Schmitz G.; Approaching clinical proteomics: current state and future fields of application in fluid proteomics; Clin.Chem.Lab.Med.; 47; 724
  2. Apweiler R., Aslanidis C., Deufel T., Gerstner A., Hansen J., Hochstrasser D., Kellner R., Kubicek M., Lottspeich F., Maser E., Mewes H. W., Meyer H. E., Mullner S., Mutter W., Neumaier M., Nollau P., Nothwang H. G., Ponten F., Radbruch A., Reinert K., Rothe G., Stockinger H., Tarnok A., Taussig M. J., Thiel A., Thiery J., Ueffing M., Valet G., Vandekerckhove J., Wagener C., Wagner O., Schmitz G.; Approaching clinical proteomics: current state and future fields of application in cellular proteomics; Cytometry A.; 75; 816
  3. Bauer M., Kinkl N., Meixner A., Kremmer E., Riemenschneider M., Forstl H., Gasser T., Ueffing M.; Prevention of interferon-stimulated gene expression using microRNA-designed hairpins; Gene Ther.; 16; 142
  4. Becker K. F., Walch A., Ueffing M.; Protein analysis of tissues--current views and clinical perspectives; Virchows Arch.; 455; 191
  5. Boldt K., van Reeuwijk J., Gloeckner C. J., Ueffing M., Roepman R.; Tandem affinity purification of ciliopathy-associated protein complexes; Methods Cell Biol.; 91; 143
  6. Braun R. J., Kinkl N., Zischka H., Ueffing M.; 16-BAC/SDS-PAGE analysis of membrane proteins of yeast mitochondria purified by free flow electrophoresis; Methods Mol.Biol.; 528; 83
  7. Gloeckner C. J., Boldt K., Schumacher A., Ueffing M.; Tandem affinity purification of protein complexes from mammalian cells by the Strep/FLAG (SF)-TAP tag; Methods Mol.Biol.; 564; 359
  8. Gloeckner C. J., Boldt K., Ueffing M.; Strep/FLAG tandem affinity purification (SF-TAP) to study protein interactions; Curr.Protoc.Protein Sci.; Chapter 19; Unit19.20
  9. Gloeckner C. J., Schumacher A., Boldt K., Ueffing M.; The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro; J.Neurochem.; 109; 959
  10. Hadian K., Vincendeau M., Mausbacher N., Nagel D., Hauck S. M., Ueffing M., Loyter A., Werner T., Wolff H., Brack-Werner R.; Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein; J.Biol.Chem.; 284; 33384
  11. Hauck S. M., Ueffing M.; Muller-cell-derived neurotrophic factors, a road to neuroprotective therapy in the retina; Arch.Soc.Esp.Oftalmol.; 84; 423
  12. Paquet-Durand F., Hauck S. M., van Veen T., Ueffing M., Ekstrom P.; PKG activity causes photoreceptor cell death in two retinitis pigmentosa models; J.Neurochem.; 108; 796
  13. Zipplies J. K., Hauck S. M., Schoeffmann S., Amann B., Stangassinger M., Ueffing M., Deeg C. A.; Serum PEDF levels are decreased in a spontaneous animal model for human autoimmune uveitis; J.Proteome Res.; 8; 992

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