Ueffing Lab

Molecular Biology of Retinal Degenerations

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Cell Death Mechanisms

Retinal cross section. The cGMP (red) level increases when the rod photoreceptors die. (© Paquet-Durand)

Neurodegenerative diseases are an ever increasing health concern in the ageing human populations.

The understanding of these diseases requires the use of reliable model systems which can satisfy diverse research needs. The retina as an integral part of the central nervous system (CNS) combines easy access with a large number of animal models available for investigations of development, function and pathology.

In the group of PD Dr. François Paquet-Durand, the retina is used as a model system to investigate neuronal degeneration with a particular focus on photoreceptor cell death.

Related Projects

    Preclinical development of drugs and drug delivery technology for the treatment of inherited photoreceptor degeneration,
  • Cell Death Mechanisms
    Comparative analysis of cell death associated enzymatic activities in ten different models for retinal degeneration.