Ueffing Lab

Molecular Biology of Retinal Degenerations

Home » Labs » Ueffing Lab » Research Topics » Parkinson Disease

Molecular Mechanism of Parkinson Disease

Parkinson Disease (PD) is the second most common neurodegenerative disorder. Besides the sporadic form of PD (idiopathic PD) characterized by a complex etiology and the absence of a clear pattern of inheritance, familial forms exist which are caused by single gene defects.

The leucine-rich repeat kinase 2 (LRRK2) is the most prevalent gene associated with those forms of Parkinson's Disease which are familial and caused by a single gene defect. We employ biochemical, cell biological and biophysical approaches as well as structural biology techniques to investigate the molecular basis of LRRK2's physiological and pathophysiological function.

Related Projects

  • LRRK2
    Functional Genomics - learning from protein complexes analysis of the Parkinson's Disease Protein LRRK2