Ueffing Lab

Molecular Biology of Retinal Degenerations

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Methodology - Technology Development

We apply state of the art mass spectrometry (MS) based analytical strategies, including quantitative methods like SILAC or ICPL.

During the last years our main efforts focused on the development of combinatory approaches to use the potential of quantitative MS for the analysis of protein complexes, protein networks and the impact of gene variants on those.

We further use quantitative MS to decipher the impact of mutations or noxes on the proteomic level. In combination with the detection and the dynamics of post-translational modifications, this enables us to further understand the cellular processes underlying disease.