Wissinger Lab

Molecular Genetics Laboratory

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Nicole Weisschuh

First nameNicole
Position and TitleSenior Postdoc, Dr.rer.nat.

Business address

Molecular Genetics Laboratory
Institute for Ophthalmic Research
Centre for Ophthalmology,
University of Tübingen
Elfriede-Aulhorn-Strasse 7
D-72076 Tübingen,

Phone: +49 (0)7071 29-87618

E-mail: nicole.weisschuh[at]uni-tuebingen.de

Academic Education

02/2002Diploma in Biology, Eberhard-Karls-University, Tübingen, Germany
03/1998PhD in Microbiology, Eberhard-Karls-University, Tübingen, Germany

Postdoctoral Training and Prior Positions

Since 04/2002PostDoc, Institute of Ophthalmic Research, Centre for Ophthalmology, University of Tübingen, Germany


1998 – 2000Scholarship: Graduiertenförderung Baden-Württemberg

Research interests


  • Genetics in glaucoma,
  • Genetics in inherited retinal disease - novel techniques

Research interests

  • Implementation of next generation sequencing technology in our lab using the Fluidigm 48.48 Access Array™ PCR system in combination with subsequent Roche 454 sequencing (GS Junior platform)
  • Downstream computational analysis of sequence data derived from all major next generation sequencing platforms (SOLiD, Illumina, Roche 454) to identify disease-causing mutations
  • Identification of risk factors in various glaucoma subtypes using linkage and association analysis

Editorship for Scientific Journals & Reviewer Activities

  • ad hoc reviewer for scientific journals including Hum Genet, Eur J Hum Genet, J Med Genet, Eur J Ophthalmol, Mol Vis, Ophthalmic Res.


  1. Weisschuh N, Dressler P, Schuettauf F, Wolf C, Wissinger B, Gramer E (2006) Novel mutations of FOXC1 and PITX2 in patients with Axenfeld-Rieger malformations. Invest Ophthalmol Vis Sci 47: 3846-3852.
  2. Weisschuh N, Alavi MV, Bonin M, Wissinger B (2007) Identification of genes that are linked with optineurin expression using a combined RNAi-microarray approach. Exp Eye Res 85: 450-461
  3. Weisschuh N, Wolf C, Wissinger B, Gramer E (2008) A novel mutation in the FOXC1 gene in a family with Axenfeld-Rieger syndrome and Peters' anomaly. Clin Genet 74: 476-480.
  4. Weisschuh N, Wolf C, Wissinger B, Gramer E (2009) A clinical and molecular genetic study of German patients with primary congenital glaucoma. Am J Ophthalmol 147: 744-753. 
  5. Wolf C, Gramer E, Müller-Myhsok B, Pasutto F, Reinthal E, Wissinger B, Weisschuh N (2009) Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study. BMC Med Genet 10: 91-96.
  6. Pasutto F, Matsumoto T, Mardin CY, Sticht H, Brandstätter JH, Michels-Rautenstrauss K, Weisschuh N, Gramer E, Ramdas WD, van Koolwijk LM, Klaver CC, Vingerling JR, Weber BH, Kruse FE, Rautenstrauss B, Barde YA, Reis A (2009) Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. Am J Hum Genet 85: 447-456.
  7. Weisschuh N, Wissinger B, Gramer E (2012) A splice site mutation in the PAX6 gene which induces exon skipping causes autosomal dominant inherited aniridia. Mol Vis 18: 751-757.
  8. Weisschuh N, Aisenbrey S, Wissinger B, Riess A (2012) Identification of a novel CRYBB2 missense mutation causing congenital autosomal dominant cataract. Mol Vis 18: 174-180.
  9. Pasutto F, Keller KE, Weisschuh N, Sticht H, Samples JR, Yang YF, Zenkel M, Schlötzer-Schrehardt U, Mardin CY, Frezzotti P, Edmunds B, Kramer PL, Gramer E, Reis A, Acott TS, Wirtz MK (2012) Variants in ASB10 are associated with open-angle glaucoma. Hum Mol Genet 21: 1336-1349.
  10. van Koolwijk LM, Ramdas WD, Ikram MK, Jansonius NM, Pasutto F, Hysi PG, Macgregor S, Janssen SF, Hewitt AW, Viswanathan AC, ten Brink JB, Hosseini SM, Amin N, Despriet DD, Willemse-Assink JJ, Kramer R, Rivadeneira F, Struchalin M, Aulchenko YS, Weisschuh N, Zenkel M, Mardin CY, Gramer E, Welge-Lüssen U, Montgomery GW, Carbonaro F, Young TL; DCCT/EDIC Research Group, Bellenguez C, McGuffin P, Foster PJ, Topouzis F, Mitchell P, Wang JJ, Wong TY, Czudowska MA, Hofman A, Uitterlinden AG, Wolfs RC, de Jong PT, Oostra BA, Paterson AD; Wellcome Trust Case Control Consortium 2, Mackey DA, Bergen AA, Reis A, Hammond CJ, Vingerling JR, Lemij HG, Klaver CC, van Duijn CM (2012) Common genetic determinants of intraocular pressure and primary open-angle glaucoma.PLoS Genet May;8(5): e1002611.