Molecular Genetics Laboratory
European Research Project on Mendelian Inherited Optic Neuropathies
Inherited optic neuropathies (IONs) represent a genetically heterogeneous group of degenerative disorders of the optic nerve that affect more than 50.000 persons in Europe. The five main objectives of ERMION are the following :
- establishment of joint biological resources to study the genetics and cellular pathophysiology of IONs.
- mapping of new gene loci and identification of new genes associated with ION.
- identification of proteins that interact with OPA1, a major disease factor in IONs.
- studying the mitochondrial and cellular disease process in retinal ganglion cells obtained from OPA1 mouse models.
- investigation of cellular changes in mitochondrial bioenergetics and dynamics induced by OPA1 dysfunction in human neuronal like cells and their application for the evaluation of drugs with potential therapeutic effect.
|Project Coordinator:||Dominique Bonneau, Angers (France)|
|Other Partners:||Bernd Wissinger (Tübingen, Germany), Guy Lenears (Montpellier/France), Andrea Martinuzzi (Conegliano, Italy)|
|Funding Agency:||BMBF-DLR (ERA-Net Program), Contract-No.: 01GM1006|
|Funding Period:||05/2010 - 04/2013 (36 Month)|