Zrenner Lab

Experimental Retinal Prosthetics Group

SysRetPro: SYStems neuroscience in service of the next-generation RETinal PROsthesis

SysRetPro uses linear systems analysis and explicit (visual and electrical) stimulus-response models to better understand how both light and electrical stimulation are encoded by the mouse retina. These models are used to improve the visual experiences of retinal implant patients. By altering the functioning of retinal implants to generate more natural spike patterns for the brain, we seek to perfect the simulated visual world of bionic vision recipients.

PartnerRathbun, Hosseinzadeh, Jalligampala, Sekhar, Sadeghi
DatesOct. 2013 – Mar. 2019
Funding Insititutions

Results

  1. Hosseinzadeh Z, Jalligampala A, Zrenner E, Rathbun DL.  “The spatial extent of epiretinal electrical stimulation in the healthy mouse retina.”  Neurosignals.  2017 Jul 26;25(1):15-25.
  2. Sekhar S, Jalligampala A, Zrenner E, Rathbun DL.  “Correspondence between visual and electrical input filters of ON and OFF mouse retinal ganglion cells.”  J. Neural Eng. 2017 May;14(4):046017.
  3. Jalligampala A, Sekhar S, Zrenner E, Rathbun DL.  "Optimal Voltage Stimulation Parameters for Network-Mediated Responses in Wild Type and rd10 Mouse Retinal Ganglion Cells.” J. Neural Eng.  2017 Apr;14(2):026004.
  4. Sekhar S, Jalligampala A, Zrenner E, Rathbun DL.  “Tickling the Retina: Integration of Subthreshold Electrical Pulses can Activate Retinal Neurons.”  J. Neural Eng. 2016 Aug;13(4):046004.
  5. Rathbun DL, Sekhar S, Jalligampala A, Zrenner E.  “Linear Input Filters in Retinal Prosthetics.” Artificial Vision,
    Aachen, Germany, Nov 2015