Zrenner Lab

Experimental Retinal Prothetics Group

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Archana Jalligampala

SurnameJalligampala
First nameArchana
NationalityIndian
Present position and titlePh.D. student,  M.Sc (Neuroscience)

Business address

Experimental Retinal Prothetics Group
Institute for Ophthalmic Research
University of Tübingen
Elfriede-Aulhorn-Strasse 7
D-72076 Tübingen,
Germany

Phone: +49 (0)7071 29-87789
Fax: +49 (0)7071 29-4472
E-mail: archana.jalligampala[at]student.uni-tuebingen.de

Project Description:

The main aim of my project is to have a better understanding of the ‘FADING’ phenomena as reported by  retinitis pigmentosa patients with retinal implants (Tuebingen retinal implant).

It has been observed that patients report phosphene fading under repetitive stimulation of the implant. Such a phenomenon in the invitro world is referred to as electrical desensitization. It has been observed from previous invitro study with various animal models that under repetitive electrical stimulation the retinal ganglion cells spiking activity decreases and eventually stps.
Much is known about the temporal aspects of desensitization. My projects aims at understanding two major aspects:

  1. The electrical properties (thresholds,responsiveness) in healthy and degenerating mice model(rd10) in epiretinal (stimulation at the ganglion cell side) and subretinal ( stimulation at the bipolar/photoreceptor side) approach. A lot of studies have reported about the severely degenerated mice model rd1 in both epiretinal and subretinal configuration. However less is known about the rd10 mice model which has a slow progression of degeneration which is a close correlate to human retinitis pigmentosa.
  2. Spatial component of desensitization in subretinal approach which would be a suitable correlate towards understanding the phosphene fading in patients with Tübingen retinal implant.

Academic Education

Year Degree University Field of study
2012-present Ph.D. University of Tübingen, International Max Planck Research School (IMPRS) Neuroscience
2009-2011 M.Sc University of Tübingen Neuroscience
2004-2008 Bachelors in Technology( B.Tech) Amity University, U.P, India Biotechnology

Professional Experience

Period Institution Position Discipline
06-11/2011 Institute of Ophthalmic Research, Tuebingen, Germany Guest Scientist Ophthamology
04-07/2010 Max Planck Institute of Developmental Biology, Tuebingen, Germany Research Assistant Developmental Biology
2008-2009 Imperial Life Sciences Pvt. Ltd., Gurgaon,India Application Manager Biotech( Genomics)

Additional information

  • Hertie Clinical Brain Research Scholarship 09/2009 - 10/2010
  • NMI Stipend from 11/2010 - 5/2011
  • Pro-Retina Ph.D. Stipendium Awardee 2013
  • Best Poster Award - ICNPD 2012, Freiburg i.Br., Germany
  • President Guide, Orissa awarded by President of India-K.R Narayan
  • Award for best Interpersonal and Team Skill Management-Amity University 2008
  • Star Achiever Amity Institute of Biotechnology, Amity University Lucknow Campus Batch 2004-2008

Publications

  1. Jalligampala A, Sekhar S, Zrenner E, Rathbun DL: Optimal voltage stimulation parameters for network-mediated responses in wild type and rd10 mouse retinal ganglion cells; J Neural Eng. 2017 Feb 3;14(2):026004. doi: 10.1088/1741-2552/14/2/026004. [Epub ahead of print]
  2. Rathbun DL and Jalligampala A (2012). Electrically Evoked Responses Of Retinal Ganglion Cells In Wild Type and Rd10 Mouse Retinas.. Front. Comput. Neurosci. Conference Abstract: Bernstein Conference 2012. doi: 0.3389/conf.fncom.2012.55.00084