Zrenner Lab

Pathophysiology of Vision

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Ayse Sahaboglu

SurnameSahaboglu
First nameAyse
NationalityTurkish
Present position and titleProject leader, Dr.rer.nat.

Business address

Institute for Ophthalmic Research
University of Tübingen
Elfriede-Aulhorn-Strasse 7
D-72076 Tübingen,
Germany

Phone: +49 (0)7071 29 80769
Fax: +49 (0) 7071 29 5777
E-mail: ayse.sahaboglu-tekgoez[at]uni-tuebingen.de

Academic Education

Year Degree University Field of study
2008 - 2012 Dr. rer. nat., Doctoral thesis completed in May 2012: “Investigation of cGMP mediated PARP activity in retinal degeneration” University of Tübingen Life Sciences
2003 - 2006 MSc in Biology, Master thesis completed in May 2006: The investigations of apoptosis in ischemia-reperfusion induced rat retina Harran University Biology
2001 - 2003 Master student in Biology Gazi University Biology
1997 - 2001 Bachelor of Science, Department of Biological Sciences, Elazig, Turkey Firat University Biology

Professional Experience

Period Position
08.2017 - present Project leader of DFG funded project. Institute for Ophthalmic Research, Tubingen, Germany.
11.2016 - 08.2017 Project leader of Tistou & Charlotte Kerstan Foundation funded project “Neuroprotection of photoreceptors” Institute for Ophthalmic Research, Tubingen, Germany.
10.2015 - 10.2016 Project leader of DFG funded project “Investigating new therapeutic targets for inherited photoreceptor degeneration: Secondary medical indications for PARP inhibitors used in cancer treatment” Institute for Ophthalmic Research, Tubingen, Germany.
09.2015 - 10.2015 Project leader of Tistou & Charlotte Kerstan Foundation funded project “Personalized medicine: PARP inhibition as a means to save photoreceptors in Pde6a mutant mouse retina, genotype matched to human Retinitis Pigmentosa patients”. Institute for Ophthalmic Research, Tubingen, Germany.
2012 - 2015 Postdoc, DRUGSFORD (EU project); 304963, Preclinical development of drugs and drug delivery technology for the treatment of inherited photoreceptor degeneration.
2010 - 2012 Researcher, Deutsche Forschungsgemeinschaft (DFG) project, PA1751/3-1, The importance of protein kinase G (PKG) for cGMP-dependent cell death and neuroprotection in inherited retinal neurodegeneration Institute for Ophthalmic Research, Tubingen, Germany.
2008 - 2010 Marie Curie PhD fellow for Early Stage Research Training 'NEUROTRAIN', Institute For Ophthalmic Research, Tubingen, Germany.
2007 - 2008 Expert, Central Laboratory, Harran University, S.Urfa, Turkey.
2004 - 2006 Research assistant, department of Biology, Harran University, S.Urfa, Turkey

Professional Activities and Functions

Funded Projects

08.2017 - 07.2020 DFG (Deutsche Forschungsgemeinschaft) SA3040/3-1
10.2016 - 31.2018 Kerstan Foundation: SAH001/2017 (Principal investigator)
10.2015 - 10.2016 DFG (Deutsche Forschungsgemeinschaft) SA3040/1-1 (Principal investigator)
09.2015 - 02.2016 Kerstan Foundation: SAH001/2016 (Principal investigator)

Awards

2016, 2017 German Ophthalmological Society (DOG) award for project proposal
2015 Travel award of DAAD, Germany, for ARVO 2015 meeting, Denver (Colorado, USA).
2015 Travel award of Pro Retina, Germany for Mechanism of Neurodegeneration meeting, EMBO, Heidelberg, Germany.
2007 Travel Award, TUBITAK (The Scientific and Technological Research Council of Turkey) for Xth National Course in Stereological Methods and Applications
2006 International Scientific Publication Encouragement, ULAKBIM (Turkish Academic Network and Information Center)
2005 Travel Award, TUBITAK (The Scientific and Technological Research Council of Turkey) for Neuroscience

Invited Peer Review

2016- Peer reviewer, Cell & Tissue Research
2015- Peer reviewer, Turkish Jorrnal of Biology
2014- Peer reviewer, PeerJ
2013- Peer reviewer, Current Eye Research
2013- Peer reviewer, Elseiver, Gene

Research interest

  • Poly and mono ADP ribosylation
  • Neuronal cell death and survival
  • Retinal disorders

Additional information

Professional Association Memberships

2014- Federation of European Neuroscience Societies, (FENS)

2013-

Deutsche Gesellschaft für DNA- Reparaturforschung (DGDR)

2009-

The Association for Research in Vision and Ophthalmology (ARVO)

Publications

  1. Sahaboglu A, Sharif A, Feng L, Secer E, Zrenner E, Paquet-Durand F. (2017). Temporal progression of PARP activity in the Prph2 mutant rd2 mouse: Neuroprotective effects of the PARP inhibitor PJ34. PLoS ONE, doi 10.1371/journal.pone.0181374.
  2. Sahaboglu A, Barth M, Secer E, del Amo EM, Urtti, Arsenijevic  Y, Zrenner E, Paquet-Durand F. (2016). Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration Nature; Scientific Reports, doi: 10.1038/srep39537.
  3. Jiao K#, Sahaboglu A#, Zrenner E, Ueffing M, Ekström P, Paquet-Durand F. (2016). PARP inhibition preserves photoreceptors in compound heterozygous Pde6a mutant retina genotype matched to human Retinitis Pigmentosa. Cell Death Discovery. doi:10.1038/cddiscovery.2016.40. #These authors contributed equally
  4. Trifunović D, Arango-Gonzalez B, Comitato A, Barth M, Sahaboglu A, del Amo EM, Kulkarni M, Hauck SM, Ueffing M, Urtti A, Arsenijevic Y, Marigo V, Paquet-Durand F. (2016) HDAC inhibition protects degenerating cone photoreceptors in vivo. Human Molecular Genetics. pii: ddw275.
  5. Valdes J, Trachsel-Moncho L, Sahaboglu A, Trifunovic D, Miranda M, Ueffing M, Paquet-Durand F, Schmachtenberg O (2016) Organotypic retinal explant cultures as in vitro alternative for diabetic retinopathy studies. ALTEX. doi: 10.14573/altex.1603111.
  6. Sothilingam V, Garcia-Garrido M, Jiao K, Buena-Atienza E, Sahaboglu A, Trifunović D, Balendran S, Grau T, Beck SC, Schön C, Biel M, Mühlfriedel R, Michalakis S, Wissinger B, Seeliger MW, Paquet-Durand F. (2015) Retinitis Pigmentosa:  Impact of different Pde6a point mutations on the disease phenotype. Human Molecular Genetics. doi: 10.1093/hmg/ddv275.
  7. Schubert T, Gleiser C, Heiduschka P, Franz C, Nagel-Wolfrum K, Sahaboglu A, Weisschuh N, Eske G, Rohbock K, Rieger N, Paquet-Durand F, Wissinger B, Wolfrum U,  Hirt B, Singer W, Rüttiger L, Zimmermann U, Knipper M. (2015) Deletion of Myosin VI causes slow retinal optic neuropathy and age-related macular degeneration (AMD)-like retinal phenotype. Cellular and Molecular Life Sciences. Doi:10.1007/s00018-015-1913-3.
  8. Arango-Gonzalez B, Trifunović D, Sahaboglu A, Kranz K, Michalakis S, Farinelli P, Koch S, Fred Koch F, Cottet  S, Janssen-Bienhold U, Dedek K, Biel M, Zrenner E, Euler T, Ekström P, Ueffing M, Paquet-Durand F. (2014) Hereditary retinal degeneration is governed by a novel non-apoptotic cell death mechanism. PLoS ONE 9(11): e112142.
  9. Sahaboglu A, Tanimoto N, Bolz B, Garcia Garrido M,  Ueffing M, Seeliger MW, Löwenheim H,  Ekström P, Paquet-Durand F. (2014) Knockout of PARG110 confers resistance to cGMP induced toxicity in mammalian photoreceptors. Cell Death and Disease. doi: 10.1038/cddis.2014.208.
  10. Sahaboglu A, Bolz S, Lowenheim H, Paquet-Durand F (2014) Expression of Poly(ADP-ribose) glycohydrolase in wild-type and PARG-110 knock-out retina. Adv Exp Med Biol.  doi: 10.1007/978-1-4614-3209-8_59.
  11. Paquet-Durand F, Sahaboglu A, Dietter J, Paquet-Durand O, Hitzmann B, Ueffing M,  Ekström P (2014) How long does a photoreceptor cell take to die? Implications for the causative cell death mechanisms. Adv Exp Med Biol.  Doi:10.1007/978-1-4614-3209-8_73.
  12. Du J, Cleghorn WM, Contreras L, Lindsay K, Rountree AM, Chertov AO, Turner SJ, Sahaboglu A, Linton J, Sadilek M, Satrústegui J, Sweet IR, Paquet-Durand F, Hurley JB. (2013) Inhibition of mitochondrial pyruvate transport by Zaprinast causes massive accumulation of aspartate at the expense of glutamate in retinas. The Journal of Biological Chemistry. Doi: 10.1074/jbc.M113.507285.
  13. Sahaboglu A, Paquet-Durand O, Dengler K, Bernhard-Kurz S, Hitzmann B, Ueffing M, Paquet-Durand F. (2013) Retinitis Pigmentosa: Rapid neurodegeneration is governed by slow cell death mechanisms. Cell Death and Disease. Doi:10.1038/cddis.2013.12
  14. Trifunović D, Sahaboglu A, Kaur J, Mencl S, Zrenner E, Ueffing M, Arango-Gonzalez B, Paquet-Durand F. (2012) Neuroprotective Strategies for the Treatment of Inherited Photoreceptor Degeneration. Curr Mol Med. 12(5):598-612.
  15. Kaur J, Mencl S, Sahaboglu A, van Veen T, Zrenner E, Ekstrom P, Paquet Durand F, Arango-Gonzalez B. (2011) Calpain and PARP Activation during Photoreceptor Cell Death in P23H and S334ter Rhodopsin Mutant Rats. PLoS ONE. 6 (7):e22181.
  16. Sahaboglu A, Tanimoto N, Kaur J, Sancho-Pelluz J, Huber G, Fahl E, Arango-Gonzalez B, Zrenner E, Ekström P, Löwenheim H, Seeliger M, Paquet-Durand F. (2010) PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function. PLoS ONE 5(11): e15495.
  17. Sancho-Pelluz J, Alavi M, Sahaboglu A, Kustermann S, Farinelli P, Azadi S, van Veen T, Romero FJ, Paquet-Durand F, Ekström P. (2010) Excessive HDAC activation critical for neurodegeneration in the rd1 mouse. Cell Death & Disease, doi:10.1038/cddis.2010.4.
  18. Huber G, Beck SC, Grimm C, Sahaboglu-Tekgoz, A, Paquet-Durand F, Wenzel A, Seeliger MW, Fischer MD. (2009) Spectral domain optical coherence tomography in mouse models of retinal degeneration. Investigative Ophthalmology & Visual Science 50(12):5888-5995.
  19. Dilsiz N, Sahaboglu A, Yıldız MZ, and Reichenbach A. (2006) Protective effects of various antioxidants during ischemia-reperfusion in the rat retina. Graefe’s Archive for Clinical and Experimental Ophthalmology 244 (5): 627-633.