Clark Lab

Molecular mechanisms driving age-related macular degeneration

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Alexander Viktor Tschulakow

Surname Tschulakow
First name Alexander Viktor
Nationality German
Present position and title Postdoc Dr.rer.nat.

Business address

Institute for Ophthalmic Research
Eberhard Karls University of Tübingen
Elfriede-Aulhorn-Strasse 7
D-72076 Tübingen,
Germany

Phone: +49 7071 29-84774
E-mail: Alexander.Tschulakow[at]med.uni-tuebingen.de

Academic Education

Year Degree University Field of study
2018 Dr.rer.nat. Eberhard Karls University of Tuebingen Ophthalmology, tumor biology
2007 Diploma in Humanbiology E-M.-Arndt University of Greifswald Molecular microbiology

Professional Experience

Period Institution Position Discipline
2018 postdoc Centre for Ophthalmology, Tuebingen
Section of Experimental Vitreoretinal Surgery		 Ophthalmology
2013-2018 Doctoral candidate Centre for Ophthalmology, Tuebingen
Section of Experimental Vitreoretinal Surgery		 Ophthalmology
2010-2011 research assistant Baptist University Hong Kong Tumor biology
2010 research assistant University of Mainz Tumor biology
2008-2009 research assistant University of Luebeck Immunology, sleep studies

Selected Publications

  1. Penetration, distribution, and elimination of remofuscin/soraprazan in Stargardt mouse eyes following a single intravitreal injection using pharmacokinetics and transmission electron microscopic autoradiography: Implication for the local treatment of Stargardt's disease and dry age-related macular degeneration. 
    Julien-Schraermeyer S, Illing B, Tschulakow A, Taubitz T, Guezguez J, Burnet M, Schraermeyer U.
    Pharmacol Res Perspect. 2020 Dec;8(6):e00683. doi: 10.1002/prp2.683. PMID: 33164337; PMCID: PMC7649431.

  2. Removal of RPE lipofuscin results in rescue from retinal degeneration in a mouse model of advanced Stargardt disease: Role of reactive oxygen species.
    Fang Y, Taubitz T, Tschulakow AV, Heiduschka P, Szewczyk G, Burnet M, Peters T, Biesemeier A, Sarna T, Schraermeyer U, Julien-Schraermeyer S.
    Free Radic Biol Med. 2022 Mar;182:132-149. doi: 10.1016/j.freeradbiomed.2022.02.025. Epub 2022 Feb 25. PMID: 35219849.

  3. A new rat model of treatment-naive quiescent choroidal neovascularization induced by human VEGF165 overexpression.
    Liu S, Biesemeier AK, Tschulakow AV, Thakkar HV, Julien-Schraermeyer S, Schraermeyer U.
    Biol Open. 2020 Feb 21. pii: bio.048736. doi: 10.1242/bio.048736. [Epub ahead of print]

  4. Fundus autofluorescence, spectral-domain optical coherence tomography, and histology correlations in a Stargardt disease mouse model.
    Fang Y, Tschulakow AV, Taubitz T, Illing B, Biesemeier A, Julien-Schraermeyer S, Radu RA, Jiang Z, Schraermeyer U.
    FASEB J. 2020 Mar;34(3):3693-3714. doi: 10.1096/fj.201901784RR. Epub 2020 Jan 27.

  5. Data showing the shapes of cones and Müller cells within the fovea of monkeys reconstructed from serial sections and focused ion beam analysis.
    Schraermeyer U; Schmelzle S; Tschulakow AV.
    Data Brief. 2018 Sep 5;20:1332-1336. doi: 10.1016/j.dib.2018.08.195. eCollection 2018 Oct.

  6. Ultrastructural alterations in the retinal pigment epithelium and photoreceptors of a Stargardt patient and three Stargardt mouse models: indication for the central role of RPE melanin in oxidative stress.
    Taubitz T, Tschulakow AV, Tikhonovich M, Illing B, Fang Y, Biesemeier A, Julien-Schraermeyer S, Schraermeyer U.
    PeerJ. 2018 Jul 19;6:e5215. doi: 10.7717/peerj.5215. eCollection 2018.

  7. The anatomy of the foveola reinvestigated.
    Tschulakow AV., Oltrup T, Bende T, Schmelzle S, Schraermeyer U.
    PeerJ 2018 Mar 12, 6, e4482. doi:10.7717/peerj.4482

  8. The radioprotector ortho-phospho-L-tyrosine (pTyr) attenuates the side effects of fractionated irradiation in retinoblastoma mouse models but also decreases the local tumour control.
    Tschulakow AV, Dittmann K, Huber SM, Klumpp D, Stegen B, Schraermeyer U, Rodemann HP, Julien-Schraermeyer S.
    Radiother Oncol. 2017 Jul 12; pii: S0167-8140(17)30434-6. doi: 10.1016/j.radonc.2017.06.023.

  9. Effects of intravitreally injected Fc fragment on rat eyes.
    Taubitz T, Steinbrenner LP, Tschulakow AV, Biesemeier A, Julien-Schraermeyer S, Schraermeyer U.
    Graefes Arch Clin Exp Ophthalmol. 2016 Dec 25; 4(12):2401-2409. doi: 10.1007/s00417-016-3511-y.

  10. Establishment of a novel retinoblastoma (Rb) nude mouse model by intravitreal injection of human Rb Y79 cells - comparison of in vivo analysis versus histological follow up.
    Tschulakow AV, Schraermeyer U, Rodemann HP, Julien-Schraermeyer S.
    Biol Open. 2016 Nov 15; 5(11):1625-1630. doi: 10.1242/bio.019976.

  11. The Effects of VEGF-A-inhibitors aflibercept and ranibizumab on the ciliary body and iris of monkeys.
    Ludinsky M; Christner S; Su N; Taubitz T; Tschulakow AV; Biesemeier AK; Julien S; Schraermeyer U.
    Graefes Arch Clin Exp Ophthalmol. 2016 Jun 25; 4(6):1117-25. doi: 10.1007/s00417-016-3344-8.

  12. Effects of a single intravitreal injection of aflibercept and ranibizumab on glomeruli of monkeys.
    Tschulakow AV, Christner S, Julien S, Ludinsky M, van der Giet M, Schraermeyer U.
    PLoS One. 2014 Nov 21; 9(11):e113701. doi: 10.1371/journal.pone.0113701.

  13. First study of oral Artenimol-R in advanced cervical cancer: clinical benefit, tolerability and tumour markers.
    Jansen FH, Adoubi I, Kouassi Comoe JC, De Cnodder T, Jansen N, Tschulakow AV, Efferth T.
    Anticancer Res. 2011 Nov 31; 4417-4422. doi: -

  14. Sleep and circadian rhythm regulate circulating complement factors and immunoregulatory properties of C5a.
    Reis ES, Lange T, Köhl G, Herrmann A, Tschulakow AV, Naujoks J, Born J, Köhl J.
    Brain Behav Immun. 2011 Oct 25; (7):1416-26. doi: 10.1016/j.bbi.2011.04.011.

  15. A new approach to the memory of water.
    Tschulakow AV, Yan Y, Klimek W.
    Homeopathy. 2005 Oct 9; 4, 241-247. doi: 10.1016/j.homp.2005.07.003.