Clark Lab
Molecular mechanisms driving age-related macular degeneration
Sarah de Jong
| Surname | de Jong |
|---|---|
| First name | Sarah |
| Nationality | German |
| Present position and title | Post-doctoral research associate |
Business address
Institute for Ophthalmic Research
Eberhard Karls University of Tübingen
Elfriede-Aulhorn-Strasse 7
D-72076 Tübingen,
Germany
Phone: +49 7071 29-87891
E-mail: sarah.de-jong[at]med.uni-tuebingen.de
Academic Education
| Year | Degree | University | Field of study |
|---|---|---|---|
2015-2017 | MSc | Lund University | Biomedicine |
2011-2014 | Bsc | Heinrich-Heine Universität Düsseldorf | General Biology |
Professional Experience
| Period | Institution | Position | Discipline |
|---|---|---|---|
2017-2021 | Radboud University Medical Center | To be awarded: PhD | Functional genomics in age-related macular degeneration |
Selected Publications
- de Jong S, Koolen L, de Breuk A, Albert S, Hoyng CB, Katti S, Hollander AI, Garanto A. Generation of an iPSC line (SCTCi014-A) and isogenic control line (SCTCi014-A-1) from an age-related macular degeneration patient carrying the variant c.355G>A in the CFI gene. Stem cell Res. 2022 Apr;62:102797
- de Jong S, Koolen L, de Breuk A, Albert S, Hoyng CB, Katti S, Hollander AI, Garanto A. Generation of an iPSC line (SCTCi015-A) and isogenic control line (SCTCi015-A-1) from an age-related macular degeneration patient carrying the variant c.355G>A in the CFI gene. Stem cell Res. 2022 Apr;62:102796
- de Jong S, de Breuk A, Bakker B, Katti S, Hoyng CB, Nilsson SC, Blom AM, van den Heuvel LP, den Hollander AI, Volokhina EB. Functional analysis of variants in complement factor I identified in age-related macular degeneration and atypical hemolytic uremic syndrome. Front. Immunol. 2022 Jan: 12:789897
- de Jong S*, de Breuk A*, Volokhina EB, Bakker B, Garanto A, Fauser S, Katti S, Hoyng CB, Lechanteur YTE, van den Heuvel LP, den Hollander AI. Systemic complement levels in patients with age-related macular degeneration carrying rare or low frequency variants in the CFH gene. Hum Mol Genet. 2022 Feb 3;31(3):455-470.
*These authors contributed equally to this work. - de Jong S, Gagliardi G, Garanto A, de Breuk A, Lechanteur YTE, Katti S, van den Heuvel LP, Volokhina EB, den Hollander AI. Implications of genetic variation in the complement system in age-related macular degeneration. Prog Retin Eye Res. 2021 Sep;84: 100952.
- de Jong S, Volokhina EB, de Breuk A, Nilsson SC, de Jong EK, van der Kar NCAJ, Bakker B, Hoyng CB, van den Heuvel LP, Blom AM, den Hollander AI. Effect of rare coding variants in the CFI gene on Factor I expression levels. Hum Mol Genet. 2020;29:2313-232
- Kremlitzka M*, Geerlings MJ*, de Jong S, Bakker B, Nilsson SC, Fauser S, Hoyng CB, de Jong EK, den Hollander AI, Blom AM. Functional analyses of rare genetic variants in complement component C9 identified in patients with age-related macular degeneration. Hum Mol Genet. 2018;27:2678-2688.
*These authors contributed equally to this work.
Sarah de Jong