Clark Lab

Molecular mechanisms driving age-related macular degeneration

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Sarah de Jong

Surname de Jong
First name Sarah
Nationality German
Present position and title Post-doctoral research associate

Business address

Institute for Ophthalmic Research
Eberhard Karls University of Tübingen
Elfriede-Aulhorn-Strasse 7
D-72076 Tübingen,

Phone: +49 7071 29-87891

Academic Education

Year Degree University Field of study



Lund University




Heinrich-Heine Universität Düsseldorf

General Biology

Professional Experience

Period Institution Position Discipline


Radboud University Medical Center

To be awarded: PhD

Functional genomics in age-related macular degeneration

Selected Publications

  1. de Jong S, de Breuk A, Bakker B, Katti S, Hoyng CB, Nilsson SC, Blom AM, van den Heuvel LP, den Hollander AI, Volokhina EB. Functional analysis of variants in complement factor I identified in age-related macular degeneration and atypical hemolytic uremic syndrome. Front. Immunol. 2021, in press.
  2. de Jong S*, de Breuk A*, Volokhina EB, Bakker B, Garanto A, Fauser S, Katti S, Hoyng CB, Lechanteur YTE, van den Heuvel LP, den Hollander AI. Systemic complement levels in patients with age-related macular degeneration carrying rare or low frequency variants in the CFH gene. Hum Mol Genet. 2021, in press. *These authors contributed equally to this work.
  3. de Jong S, Gagliardi G, Garanto A, de Breuk A, Lechanteur YTE, Katti S, van den Heuvel LP, Volokhina EB, den Hollander AI. Implications of genetic variation in the complement system in age-related macular degeneration. Prog Retin Eye Res. 2021 Sep;84: 100952.
  4. de Jong S, Volokhina EB, de Breuk A, Nilsson SC, de Jong EK, van der Kar NCAJ, Bakker B, Hoyng CB, van den Heuvel LP, Blom AM, den Hollander AI. Effect of rare coding variants in the CFI gene on Factor I expression levels. Hum Mol Genet. 2020;29:2313-232
  5. Kremlitzka M*, Geerlings MJ*, de Jong S, Bakker B, Nilsson SC, Fauser S, Hoyng CB, de Jong EK, den Hollander AI, Blom AM. Functional analyses of rare genetic variants in complement component C9 identified in patients with age-related macular degeneration. Hum Mol Genet. 2018;27:2678-2688. *These authors contributed equally to this work.