Clark Lab

Molecular mechanisms driving age-related macular degeneration

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Research Projects (current)

The Clark lab has an ever-evolving landscape of specific projects that focus on our Main Research Themes. Currently, these include:

  • Elucidating the extracellular matrix (ECM) interaction properties of FHL-1 and the FHR proteins, and the consequences for complement activation on ECM
  • Employing Artificial Intelligence in disease risk and progression analysis for AMD and diabetic retinopathy
  • Investigating the mechanisms underlying AAV-mediated immunogenicity in patients receiving gene-therapies
  • Understanding the influence of ECM re-modelling in destabilising RPE cell homeostasis and the effect on retinal resilience and longevity
  • Investigating the role of Inter-Alpha-Inhibitor Heavy Chain 3 (ITIH3) in age-related macular degeneration
  • A comprehensive molecular analysis and iPSC model of early adult-onset macular degeneration to better understand age-related macular degeneration.
  • Development and utilisation of the Helmut Ecker Eye Tissue Resource (HEETR) to elucidate molecular pathology of AMD
  • Investigating the Influence of Genetic Variation Associated with Age-Related Macular Degeneration on Plasma Levels of Complement Regulatory Proteins