Schnichels Lab

Neuroprotection & Drug Delivery

2020

  1. Mueller-Buehl AM, Doepper H, Grauthoff S, Kiebler T, Peters L, Hurst J, Kuehn S, Bartz-Schmidt KU, Dick HB, Joachim SC, Schnichels S+ Oxidative stress-induced retinal damage is prevented by mild hypothermia in an ex vivo model of cultivated porcine retinas. Clin Exp Ophthalmol. 2020 Feb 19. doi: 10.1111/ceo.13731. [Epub ahead of print] IF: 3,411

2019

  1. Schnichels S+ Young DOG @ Vision Camp 2019 Ophthalmologe. 2019 Sep;116(9): 897-898. IF: 0,679, Editorial
  2. Schnichels S+, Kiebler T, Hurst J, Maliha AM, Löscher M, Dick HB, Bartz-Schmidt KU, Joachim SC Retinal Organ Cultures as Alternative Research Models. Altern Lab Anim. 2019 Mar;47(1):19-29. IF: 1.326, Review
  3. Klemm P, Hurst J, Dias Blak M, Herrmann T, Melchinger M, Bartz-Schmidt KU, Zeck G, Schultheiss M, Spitzer MS, Schnichels S+ Hypothermia protects retinal ganglion cells against hypoxia-induced cell death in a retina organ culture model. Clin Exp Ophthalmol. 2019 Nov;47(8):1043-1054. doi: 10.1111/ceo.13565. Epub 2019 Jul 2 IF: 3,411
  4. Maliha AM, Kühn S, Hurst J, Herms F, Fehr M, Bartz-Schmidt KU, Dick HB, Joachim SC & Schnichels S+ Diminished apoptosis in hypoxic porcine retina explant cultures through hypothermia Scientific Reports 2019 Mar 20;9(1):4898. IF: 4,011
  5. Mueller S, Krupp C, Schnichels S, Hofmann J, Spitzer M, Bartz-Schmidt KU, Szurman P, Januschowski K. Investigating retinal toxicity of a lutein-based dye in a model of isolated and perfused bovine retina. Graefes Arch Clin Exp Ophthalmol. 2019 Feb 20. [Epub ahead of print] IF: 2,250
  6. Januschowski K, Schnichels S, Hurst J, Hohenadl C, Reither C, Rickmann A, Pohl L, Bartz-Schmidt KU & Spitzer MS Ex vivo biophysical characterization of a hydrogel-based artificial vitreous substitute. PLoS One. 2019 Jan 7;14(1):e0209217.. eCollection 2019. IF: 2,766

2018

  1. Wu Z, Troll J, Jeong HH, Wei Q, Stang M, Ziemssen F, Wang Z, Dong M, Schnichels S, Qiu T & Fischer P A swarm of slippery micropropellers penetrates the vitreous body of the eye. Sci Adv. 2018 Nov 2;4(11):eaat4388. IF: 12,804
  2. Schnichels S+ Wie schreibe ich ein Paper. Ophthalmologe. 2018 Sep;115(9):797-798. IF: 0,679, Editorial

2017

  1. Spitzer MS & Schnichels S Dwarf with gigantic future potential. Ophthalmologe. 2018 Mar;115(3):182-183 Epub: 2017 Dec 19. IF: 0,679, Editorial
  2. de Vries JW, Schnichels S*, Hurst J, Strudel L, Gruszka A, Kwak M, Bartz-Schmidt KU, Spitzer MS & Herrmann A DNA nanoparticles for ophthalmic drug delivery. Biomaterials. 2018 Mar;157:98-106. Epub 2017 Nov 29. IF: 10,279
  3. Hurst J, Vitkute M, Hofmann K, Müller S, Löscher M, Bartz-Schmidt KU, Spitzer MS, Schnichels S# & Januschowski K Comparison of Different Cell Culture Media in the Model of the Isolated and Superfused Bovine Retina: Investigating the Limits of More Physiological Perfusion Solutions. Curr Eye Res. 2018 Feb;43(2):232-243. Epub 2017 Nov 7. IF: 1,672
  4. Löscher M, Hurst J, Strudel L, Spitzer MS & Schnichels S+ Nanoparticles as drug delivery systems in ophthalmology. Ophthalmologe. 2018 Mar;115(3):184-189. Epub: 2017 Nov 6. Review IF: 0,679, Review
  5. Schnichels S+, Blak M, Hurst J, Dorfi T, Bartz-Schmidt KU, Ziemssen F, Spitzer MS & Schultheiss M Establishment of a retinal hypoxia organ culture model. Biol Open. 2017 Jul 15;6(7):1056-1064. IF: 2,217
  6. Ebner M, Mariacher S, Hurst J, Szurman P, Schnichels S, Spitzer MS & Januschowski K. Characterization of a Standardized Ex-vivo Porcine Model to Assess Short Term Intraocular Pressure Changes and Trabecular Meshwork Vitality After Pars Plana Vitrectomy with Different Silicone Oil and BSS Tamponades. Curr Eye Res. 2017 Apr 25:1-6. Epub 2017 Apr 25. IF: 2,120
  7. Hurst J, Kuehn S, Jashari A, Tsai T, Bartz-Schmidt KU, Schnichels S+# & Joachim SC. A novel porcine ex vivo retina culture model for oxidative stress induced by H₂O₂. Altern Lab Anim. 2017 Mar;45(1):11-25. IF: 1,865
  8. Hurst J, Schnichels S, Spitzer MS, Bartz-Schmidt KU, Farecki ML, Szurman P & Januschowski K Negative Effects of Acid Violet-17 and MBB Dual In Vitro on Different Ocular Cell Lines. Curr Eye Res. 2017 Aug;42(8). Epub 2017 Mar 30. IF: 2,120
  9. Schnichels S, Schneider N, Hohenadl C, Hurst J, Schatz A, Januschowski K & Spitzer MS Efficacy of two different thiol-modified crosslinked hyaluronate formulations as vitreous replacement compared to silicone oil in a model of retinal detachment. PLoS One. 2017 Mar 1;12(3) eCollection 2017. IF: 2,766
  10. Kuehn S, Hurst J, Jashari A, Ahrens K, Tsai T, Wunderlich IM, Dick HB, Joachim SC# & Schnichels S+ The Novel Induction of Retinal Ganglion Cell Apoptosis in Porcine Organ Culture by NMDA — An Opportunity for the Replacement of Animals in Experiments Altern Lab Anim. 2016 Dec;44(6):557-568. IF: 1,012
  11. Kuehn S, Hurst J, Rensinghoff F, Tsai T, Grauthoff S, Satgunarajah Y, Dick HB, Schnichels S#+ & Joachim SC. Degenerative effects of cobalt-chloride treatment on neurons and microglia in a porcine retina organ culture model. Exp Eye Res. 2017 Feb;155:107-120. Epub 2017 Jan 12. IF: 3,152
  12. Schultheiss M, Schnichels S, Konrad EM, Bartz-Schmidt KU, Zahn G, Caldirola P, Fsadni MG, Caram-Lelham N & Spitzer MS. α5β1-Integrin inhibitor (CLT-28643) effective in rabbit trabeculectomy model. Acta Ophthalmol. 2017 Feb;95(1):e1-e9. Epub 2016 Aug 31. IF: 3,324
  13. Süsskind D, Hurst J, Rohrbach JM & Schnichels S Novel mouse model for primary uveal melanoma: a pilot study. Clin Exp Ophthalmol. 2017 Mar;45(2):192-200. doi: 10.1111/ceo.12814. Epub 2016 Sep 7. IF: 3,217

2016

  1. Mariacher S, Ebner M, Januschowski K, Hurst J, Schnichels S & Szurman P Investigation of a novel implantable suprachoroidal pressure transducer for telemetric intraocular pressure monitoring. Exp Eye Res. 2016 Oct;151:54-60. Epub 2016 Jul 22. IF: 3,332
  2. Schnichels S+, Dorfi T, Schultheiss M, Arango-Gonzalez B, Bartz-Schmidt KU, Januschowski K, Spitzer MS & Ziemssen F Ex-vivo-examination of ultrastructural changes in organotypic retina culture using near-infrared imaging and optical coherence tomography. Exp Eye Res. 2016 Jun;147:31-6. Epub 2016 Apr 21. IF: 3,332
  3. Süsskind D, Hagemann U, Schrader M, Januschowski K, Schnichels S & Aisenbrey S Toxic effects of melphalan, topotecan and carboplatin on retinal pigment epithelial cells. Acta Ophthalmol. 2016 Aug;94(5):471-8. Epub 2016 Feb 19. IF: 3,157
  4. Schultheiss M, Schnichels S+, Hermann T, Hurst J, Feldkaemper M, Arango-Gonzalez B, Ueffing M, Bartz-Schmidt KU, Zeck G & Spitzer MS Hypothermia Protects and Prolongs the Tolerance Time of Retinal Ganglion Cells against Ischemia. PLoS One. 2016 Feb 5;11(2):e0148616. eCollection 2016. IF: 2,806
  5. Januschowski K, Krupp C, Mueller S, Hofmann K, Schnichels S, Hagemann U, Spitzer MS, Bartz-Schmidt KU & Aisenbrey S Investigating short-term toxicity of melphalan in a model of an isolated and superfused bovine retina. Graefes Arch Clin Exp Ophthalmol. 2016 Jan;254(1):91-6. Epub 2015 Sep 3. IF: 2,349

2015

  1. Januschowski K, Mueller S, Krupp C, Spitzer MS, Hurst J, Schultheiss M, Bartz-Schmidt KU, Szurman P & Schnichels S Glutamate and hypoxia as a stress model for the isolated perfused vertebrate retina. J Vis Exp. 2015 Mar 22;(97). IF: 1,113

2014

  1. Januschowski K, Mueller S, Dollinger R, Schnichels S, Hofmann J, Spitzer MS, Bartz-Schmidt KU, Szurman P & Thaler S Investigating retinal toxicity of tempol in a model of isolated and perfused bovine retina. Graefes Arch Clin Exp Ophthalmol. 2014 Jun;252(6):935-41. Epub 2014 May 2. IF: 1,908
  2. Schultheiss M, Schnichels S+, Mlynczak T, Hofmann J, Bartz-Schmidt KU, Szurman P & Spitzer MS Cyclosporine A Protects RGC-5 Cells From Excitotoxic Cell Death J Glaucoma. 2014 Apr-May;23(4):219-24. IF: 2,106
  3. Januschowski K, Schnichels S+, Hagemann U, Koch V, Hofmann J, Spitzer MS, Bartz-Schmidt KU, Szurman P, Lüke M & Aisenbrey S Electrophysiological toxicity testing of VEGF Trap-Eye in an isolated perfused vertebrate retina organ culture model. Acta Ophthalmol. 2014 Jun;92(4):e305-11. Epub 2013 Nov 8. IF: 2,844

2013

  1. Schnichels S, Hagemann U, Januschowski K, Hofmann J, Bartz-Schmidt KU, Szurman P, Spitzer MS & Aisenbrey S Comparative toxicity and proliferation testing of aflibercept, bevacizumab and ranibizumab on different ocular cells. Br J Ophthalmol. 2013 Jul;97(7):917-23. Epub 2013 May 17. IF: 2,809
  2. Schultheiss M, Januschowski K, Ruschenburg H, Schramm C, Schnichels S, Szurman P, Bartz-Schmidt KU & Spitzer MS Dulbecco's Modified Eagle Medium is neuroprotective when compared to standard vitrectomy irrigation solution. Graefes Arch Clin Exp Ophthalmol. 2013 Jun;251(6):1613-9. Epub 2013 Jan 11. IF: 2,333

2012

  1. Spitzer MS, Sat M, Schramm C, Schnichels S, Schultheiss M, Yoeruek E, Dzhelebov D & Szurman P Biocompatibility and Antifibrotic Effect of UV-Cross-Linked Hyaluronate as a Release-System for Tranilast after Trabeculectomy in a Rabbit Model-a Pilot Study Curr Eye Res. 2012 Jun;37(6):463-70. IF: 1,710
  2. Januschowski K, Zhour A, Lee A, Maddani R, Mueller S, Spitzer MS, Schnichels S, Schultheiss M, Doycheva D, Bartz-Schmidt KU & Szurman P Testing the Biocompatibility of a Glutathione-containing Intra-ocular Irrigation Solution by Using an Isolated Perfused Bovine Retina Organ Culture Model - an Alternative to Animal Testing Altern Lab Anim. 2012 Mar;40(1):23-32. IF: 1,373
  3. Schnichels S+, Schultheiß M, Hofmann J, Szurman P, Bartz-Schmidt KU & Spitzer MS Trichostatin A induces apoptosis and cell death at the concentration recommended to differentiate the RGC-5 cell line Neurochem Int. 2012 May;60(6):581-91. Epub 2012 Feb 25. IF: 2,659
  4. Schultheiß M, Ruschenburg H, Schramm C, Januschowski K, Schnichels S, Biedermann T, Szurman P & Spitzer MS Neuroprotective effects of a taurine containing irrigation solution for vitrectomy Retina 2012 Jul;32(7):1343-9. Epub 2012 Feb 8. IF: 2,825
  5. Schultheiß M, Schnichels S, Miteva K, Warstat K, Szurman P, Spitzer MS & van Linthout S Staurosporine induces apoptosis at the lowest concentration that leads to “differentiation” of the RGC-5 cell line Graefes Arch Clin Exp Ophthalmol 2012 Aug;250(8):1221-9. Epub 2012 Jan 6. IF: 1,932
  6. Schnichels S, Heiduschka P & Julien S RGMA and neogenin protein expression are influenced by lens injury following optic nerve crush in the rat retina Graefes Arch Clin Exp Ophthalmol. 2012 Jan;250(1):39-50. Epub 2011 Sep 2. IF: 1,932
  7. Suesskind D, Schatz A, Schnichels S, Coupland SE, Lake SL, Wissinger B, Bartz-Schmidt KU & Henke-Fahle S GDF-15: a novel serum marker for metastases in uveal melanoma patients Graefes Arch Clin Exp Ophthalmol. 2012 Jun;250(6):887-95. Epub 2011 Sep 1. IF: 1,932

2011

  1. Gaub P, Joshi Y, Wuttke A, Naumann U, Schnichels S, Heiduschka P & Di Giovanni S The histone acetyltransferase p300 promotes intrinsic axonal regeneration. Brain. 2011 Jul;134(Pt 7):2134-48. IF: 9,457
  2. Schnichels S, Heiduschka P & Julien S Different spatial and temporal protein expressions of RGMA and neogenin in the rat optic nerve after optic nerve crush with and without lens injury J Neurosci Res. 2011 Apr;89(4):490-505. Epub 2011 Feb 2. IF: 2,783

2010

  1. Heiduschka P, Julien S, Schüttauf F & Schnichels S+ Loss of retinal function in aged DBA/2J mice – new insights into retinal neurodegeneration Exp Eye Res. 2010 Nov;91(5):779-83. Epub 2010 Sep 9. IF: 2,817
  2. Heiduschka P, Schnichels S, Fuhrmann N, Hofmeister S, Schraermeyer U, Wissinger B & Alavi MV Retinal ganglion cells are primarily affected in an animal model of OPA1 associated autosomal dominant optic atrophy. Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1424-31 2009 Oct 15. IF: 3,466

2007 - 2009

  1. Schraermeyer M, Schnichels S, Julien S, Heiduschka P, Bartz-Schmidt KU & Schraermeyer U Ultrastructural Analysis of the Pigment Dispersion Syndrome in DBA/2J Mice. Graefes Arch Clin Exp Ophthalmol. 2009 Nov;247(11):1493-504. Epub 2009 Jul 30. IF: 2,102
  2. Julien S, Kreppel F, Beck S, Heiduschka P, Brito V, Schnichels S, Kochanek S & Schraermeyer U A reproducible and quantifiable model of choroidal neovascularization induced by VEGF A165 after subretinal adenoviral gene transfer in the rabbit. Mol Vis. 2008 Jul 30;14:1358-72. IF: 2,464
  3. Julien S, Schnichels S, Teng H, Tassew N, Henke-Fahle S, Mueller BK & Monnier PP Purkinje cell survival in organotypic cultures: implication of Rho and its downstream effector ROCK. J Neurosci Res. 2008 Feb 15;86(3):531-6. IF: 2,238
  4. Schnichels S, Conrad S, Warstat K, Henke-Fahle S, Skutella T, Schraermeyer U & Julien S Gene expression of the repulsive guidance molecules/neogenin in the developing and mature mouse visual system: C57BL/6J vs. the glaucoma model DBA/2J. Gene Expr Patterns. 2007 Dec;8(1):1-11. Epub 2007 Sep 18. IF: 3,086