Prinicipal Investigator
Translational research on retinal disorders
Home » Labs » Clinical Research Labs » Fischer Lab » Members » Dominik Fischer
M. Dominik Fischer
| Surname | Fischer |
| First name | M. Dominik |
| Nationality | German/Australian |
| Present position and title | Group leader, Professor of Ophthalmology, Prof. Dr. med, D.Phil |
Business address
Institute for Ophthalmic Research
Centre for Ophthalmology,
University of Tübingen
Elfriede-Aulhorn-Strasse 7
D-72076 Tübingen,
Germany
Phone: +49 (0)7071 29-87894
E-mail: dominik.fischer[at]uni-tuebingen.de
Academic Education
| Year | Degree | University | Field of study |
|---|---|---|---|
| 2012-2015 | DPhil, Clinical Neurosciences | University of Oxford | Retinal gene and stem cell therapy |
| 2005-2007 | Medical Doctorate (summa cum laude) | University of Witten/Herdecke | Anatomy & Physiology |
| 2000-2007 | Staatsexamen | University of Witten/Herdecke | Medicine |
Professional Experience
| Period | Institution | Position | Discipline |
|---|---|---|---|
| Since 2017 | Centre for Ophthalmology Tübingen, Germany | Oberarzt (Consultant / Attending) | medical & surgical retina |
| Since 2015 | Centre for Ophthalmology Tübingen, Germany | Group leader | Retinal gene therapy |
| 2013 - 2014 | Somerville College, University Oxford, UK | Tutorial Fellow | Neurophysiology |
| 2012 - 2015 | Nuffield Laboratory of Ophthalmology, University Oxford, UK | MRC Clinical Research Fellow | Clinical Neurosciences |
| 2012 - 2015 | Oxford Eye Hospital, Oxford University Hospital NHS Trust | Honorary Senior Specialist Registrar | Ophthalmology |
| 2007 - 2012 | Centre for Ophthalmology Tübingen, Germany | Specialist trainee in Ophthalmology | Ophthalmology |
| 2001 - 2003 | Department of Physiology, University of Pennsylvania | Visiting Scholar | Physiology / Neuroscience |
Additional information
Organization of Academic Events
| Date | Description |
|---|---|
| 2017 | 101st BWAV Meeting (Innovation in neuen Gefilden, Tübingen) |
| 2016 | Electronics and Biology — Restoration of Vision in Hereditary Retinal Degenerations (DOG annual meeting, Berlin) |
| 2015 | Gene Therapy Symposium (Centre for Ophthalmology, Tübingen) |
| 2015 | YouRetina symposium (EURETINA annual meeting, Nice) |
| 2014 | Cone function minisymposium (Centre for Ophthalmology, Tübingen) |
Academic Awards
| Date | Description |
|---|---|
| 2017 | Retina Award (Retina Förderpreis), German Ophthalmological Society |
| 2017 | Research Award, Deutsches Förderprogramm für Augenheilkunde von Bayer |
| 2016 | Henning-Zügel Foundation Award for basic and translational science |
| 2015 | Professorship, Eberhard Karls Universität Tübingen |
| 2015 | Inaugural Ophthalmologica Lecturer, EURETINA Executive Committee |
| 2015 - 2017 | European Leadership Development Program, European Society of Ophthalmology |
| 2014 | Doctoral Training Award, Medical Research Council & University of Oxford |
| 2013 & 2014 | Graduate Research Grant Award, Merton College, University of Oxford |
| 2012 | Leonardo Da Vinci Grant Award, European Commission |
| 2012 | MRC Clinical Research Training Fellowship, UK Medical Research Council |
| 2012 | Glaucoma Research Award, Initiative Auge e.V. |
| 2010 | Career Development Award, Karin and Ewald Hochbaum Foundation |
| 2008 | NIH Young Investigator Award, NEI & Foundation Fighting Blindness |
| 2001 - 2007 | Academic Scholarship, Friedrich Naumann Foundation |
| 2006 | Intercultural Research Award, Peter und Ruth Wirts Stiftung |
| 2002 | Department of Physiology Research Scholarship, University of Pennsylvania |
| 2002 | Best research poster award; European Medical Student Conference |
| 2001 - 2003 | e-fellow scholarship; Accenture et al. |
| 2001 | Research travel grant, Witten/Herdecke University Society |
| 2001 | Research Scholarship, Pennsylvania Muscle Institute |
| 2001 | Henry R. Viet Fellow, Myasthenia Gravis Foundation of America |
| 2000 | Research travel grant, Smith-Kline Beecham |
Academic Teaching and Services
| Date | Description |
|---|---|
| Since 2016 | Editorial Board Member, Ophthalmology PoC |
| Since 2014 | Associate Editor, BMC Ophthalmology |
| Since 2013 | Editorial Board Member, Journal of Ophthalmic Research |
| Since 2002 | Peer Review Activity (ad hoc) for: American Journal of Physiology, Journal of Neurology, Molecular Therapy, PLoS ONE, Canadian Journal of Veterinary Research, Molecular Therapy - Methods & Clinical Development, Ophthalmology, Vision Research, Investigative Ophthalmology and Vision Research, Graefe's Arch Clinical and Experimental Ophthalmology, Ocular Immunology and Inflammation, Optometry and Vision Science, Ophthalmologica, Journal of Veterinary Ophthalmology, Molecular Vision, BMC Ophthalmology, Progress in Retinal and Eye Research; |
Memberships
- Association for Research in Vision Science and Ophthalmology
- German Society of Gene Therapy
- German Ophthalmological Society
- European Society of Retina Specialists
- German Retina Society
- European Society of Gene and Cell Therapy
- American Academy of Ophthalmology
- Oxford Ophthalmological Congress
Past and Current Funding
| Date | Description |
|---|---|
| 2015 - 2016 | IZKF (University of Tuebingen): Ex vivo gene therapy in patient derived cell cultures to predict treatment efficacy |
| 2014 – 2017 | THOR (Kerstan Foundation): Clinical phase II gene therapy trial with AAV2.REP1 for the treatment of Choroideraemia |
| 2012 - 2018 | RD-CURE (Kerstan Foundation): Work-package 5 - Strategic Planning and Coordination of two independent Clinical phase I/II gene therapy trials |
| 2012 - 2015 | UK Medical Research Council: Optimising RPGR gene replacement as treatment for X-linked RP |
| 2011 | FAMT (University of Tuebingen): Spectral domain optical coherence tomography in pre-clinical development of novel treatment strategies |
| 2010 - 2011 | fortüne (University of Tuebingen): Therapeutic intervention in a mouse model for X-linked juvenile retinoschisis |
| 2009 - 2011 | HOPE: Hereditary Retinal Dystrophies - from Patients towards Therapies (BMBF): Translation of Novel Diagnostic Procedures and Evaluation of Experimental Therapies in Hereditary Retinal Disorders |
Selected Publications
- Reichel FF, Dauletbekov DL, Klein R, Peters T, Ochakovski GA, Seitz IP, Wilhelm B, Ueffing M, Biel M, Wissinger B, Michalakis S, Bartz Schmidt KU, Fischer MD (2017) AAV8 can induce innate and adaptive immune response in the primate eye. Mol Ther accepted for publication.
- Ochakovski GA, Peters T, Michalakis S, Wilhelm B, Bartz-Schmidt KU, Fischer MD (2017) Subretinal injection for gene therapy does not cause clinically significant outer nuclear layer thinning in normal primate foveae. Invest Ophthalmol Vis Sci accepted for publication.
- Lisowska J, Lisowski L, Kelbsch C, Maeda F, Richter P, Kohl S, Zobor D, Strasser T, Stingl K, Zrenner E, Peters T, Wilhelm H, Fischer MD, Wilhelm B, Consortium R-C (2017) Development of a Chromatic Pupillography Protocol for the First Gene Therapy Trial in Patients With CNGA3-Linked Achromatopsia. Invest Ophthalmol Vis Sci 58: 1274-1282.
- Hariri AH, Velaga SB, Girach A, Ip MS, Le PV, Lam BL, Fischer MD, Sankila EM, Pennesi ME, Holz FG, MacLaren RE, Birch DG, Hoyng CB, MacDonald IM, Black GC, Tsang SH, Bressler NM, Larsen M, Gorin MB, Webster AR, Sadda SR, Natural History of the Progression of Choroideremia Study G (2017) Measurement and Reproducibility of Preserved Ellipsoid Zone Area and Preserved Retinal Pigment Epithelium Area in Eyes With Choroideremia. Am J Ophthalmol 179: 110-117.
- Fischer MD, McClements ME, Martinez-Fernandez de la Camara C, Bellingrath JS, Dauletbekov D, Ramsden SC, Hickey DG, Barnard AR, MacLaren RE (2017) Codon optimized RPGR leads to improved stability and rescue with AAV8 gene therapy in two mouse models of X-linked retinitis pigmentosa. Mol Ther. May 24. pii: S1525-0016(17)30223-X.
- Ochakovski GA, Bartz-Schmidt KU, Fischer MD (2017) Retinal Gene Therapy: Surgical Vector Delivery in the Translation to Clinical Trials. Front Neurosci. Apr 3;11:174.
- Seitz IP, Achberger K, Liebau S, Fischer MD (2016) [Stem Cells for Retina Replacement]. Klin Monbl Augenheilkd 233(12):1350-1356.
- Fischer MD, Hickey DG, Singh MS, MacLaren RE (2016) Evaluation of an Optimized Injection System for Retinal Gene Therapy in Human Patients. Human gene therapy Part B Methods 27: 150-158.
- Fischer MD (2016) On Retinal Gene Therapy. Ophthalmologica 236: 1-7 DOI 10.1159/000445782.
- Bellingrath JS, Fischer MD (2015) Gene therapy as treatment concept for hereditary retinal disorders. Ophthalmologe in print.
- Balmer J, Stanzel BV, Fischer MD (2015) Stem cell therapy for retinal diseases. Ophthalmologe in print.
- Seitz IP, Zhour A, Kohl S, Llanova P, Peters T, Wilhelm B, Zrenner E, Ueffing M, Bartz Schmidt KU, Fischer MD (2015) Multimodal assessment of choroideremia patients defines pre-treatment characteristics. Graefes Arch Clin Exp Ophthalmol in print.
- Fischer MD, Goldmann T, Wallrapp C, Muhlfriedel R, Beck SC, Stern-Schneider G, Ueffing M, Wolfrum U, Seeliger MW (2013) Successful Subretinal Delivery and Monitoring of MicroBeads in Mice. PLoS One 8: e55173.
- Zhour A, Bolz S, Grimm C, Willmann G, Schatz A, Weber BH, Zrenner E, Fischer MD (2012) In vivo imaging reveals novel aspects of retinal disease progression in Rs1h(-/Y) mice but no therapeutic effect of carbonic anhydrase inhibition. Vet Ophthalmol 15 Suppl 2: 123-133.
- Shao Y, Keliris GA, Papanikolaou A, Fischer MD, Zobor D, Jagle H, Logothetis NK, Smirnakis SM (2013) Visual cortex organisation in a macaque monkey with macular degeneration. Eur J Neurosci 38: 3456-3464.
- Fischer MD, Zobor D, Keliris GA, Yibin S, W. SM, Haverkamp S, Jägle H, Logothetis NK, Smirnakis SM (2012) Detailed functional and structural characterization of a macular lesion in a rhesus macaque. Doc Ophthalmol 125: 179-194.
- Paquet-Durand F, Beck S, Michalakis S, Goldmann T, Huber G, Muhlfriedel R, Trifunovic D, Fischer MD, Fahl E, Duetsch G, Becirovic E, Wolfrum U, van Veen T, Biel M, Tanimoto N, Seeliger MW (2011) A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa. Hum Mol Genet 20: 941-947.
- Michalakis S, Muhlfriedel R, Tanimoto N, Krishnamoorthy V, Koch S, Fischer MD, Becirovic E, Bai L, Huber G, Beck SC, Fahl E, Buning H, Paquet-Durand F, Zong X, Gollisch T, Biel M, Seeliger MW (2010) Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function. Mol Ther 18: 2057-2063.
- Fischer MD, Huber G, Beck SC, Tanimoto N, Muehlfriedel R, Fahl E, Grimm C, Wenzel A, Reme CE, van de Pavert SA, Wijnholds J, Pacal M, Bremner R, Seeliger MW (2009) Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography. PLoS One 4: e7507.
- Fischer MD, Fleischhauer JC, Gillies MC, Sutter FK, Helbig H, Barthelmes D (2008) A new method to monitor visual field defects caused by photoreceptor degeneration by quantitative optical coherence tomography. Invest Ophthalmol Vis Sci 49: 3617-3621.
Dominik Fischer