Kirsten Bucher
| Surname: | Bucher |
|---|---|
| First name(s): | Kirsten |
| Nationality: | German |
| Present position and title: | Postdoctoral research scientist; Dr. rer. nat. |
Business address
Institute for Ophthalmic Research
Centre for Ophthalmology,
University of Tübingen
Elfriede-Aulhorn-Strasse 7
D-72076 Tübingen,
Germany
Phone: +49 7071 29 87893
E-mail: kirsten.bucher@med.uni-tuebingen.de
Professional Experience
| Period | Institution | Position | Discipline |
|---|---|---|---|
| Since 2019 | Institute for Ophthalmic Research, Tübingen, Germany | Postdoctoral research scientist | Immune responses to retinal gene therapy |
| 2016 - 2018 | Department of Clinical Affairs; CRYOLIFE, Hechingen, Germany | Medical Writer | Clinical Research |
| 2010 - 2016 | Institute of Pharmacology and Toxicology, Tübingen, Germany | Postdoctoral research scientist | Immunopharmacology |
Academic Education
| Year | Degree | University | Field of study / Subjects |
|---|---|---|---|
| 2005-2010 | Dr. rer. nat. | University of Tübingen | Parasitology / Immunology |
| 1992-1995 | Staatsexamen | University of Tübingen | Biology and English |
| 1987-1992 | Studies of Biology; Subjects: Zoology, Parasitology, Pharmacology, Microbiology |
Professional Activities and Functions
Academic Teaching
| Date | Description |
|---|---|
| 2010 - 2016 | Seminar „General and systematic pharmacology and toxicology“ for medical students; Topics: Antiviral drugs, Asthma, Anti-microbial chemotherapy |
Past and Current Funding
| Date | Description |
|---|---|
| 2022 | Research grant from the PRO RETINA-Stiftung, Germany |
| 2019 - 2021 | DFG funded priority programme SPP 2127 |
Selected Publications
- Pfromm, J. K., Bonillo, M., Dauletbekov, D., Bucher, K.1 & Fischer, M. D., 2022. Plasmid-mediated gene transfer of Cas9 induces vector-related but not SpCas9-related immune responses in human retinal pigment epithelial cells. Sci Rep. 12, 13202. 1corresponding author and equal last author
- Bucher, K.1, Rodríguez-Bocanegra, E.1, Fischer, M.D. Benefits and shortcomings of in vitro model systems in the development of retinal genetic therapies. (Accepted at Klin Monbl Augenheilkd. Jan 2022); 1 equal first author
- Bucher, K., Rodríguez-Bocanegra, E., Dauletbekov, D., Fischer, M.D., 2021. Immune responses to retinal gene therapy using adeno-associated viral vectors – Implications for treatment success and safety. Prog. Retin. Eye Res. 83, 100915.
- Rodríguez-Bocanegra, E., Wozar, F., Seitz, I.P., Reichel, F.F.L., Ochakovski, A., Bucher, K., Wilhelm, B., Bartz-Schmidt, K.U., Peters, T., Fischer, M.D., 2021. Longitudinal evaluation of hyper-reflective foci in the retina following subretinal delivery of adeno-associated virus in non-human primates. Transl. Vis. Sci. Technol. 10, 1–14.
- Beer-Hammer, S., Lee, S.C., Mauriac, S.A., Leiss, V., Groh, I.A.M., Novakovic, A., Piekorz, R.P., Bucher, K., Chen, C., Ni, K., Singer, W., Harasztosi, C., Schimmang, T., Zimmermann, U., Pfeffer, K., Birnbaumer, L., Forge, A., Montcouquiol, M., Knipper, M., Nürnberg, B., Rüttiger, L., 2018. Gα i Proteins are Indispensable for Hearing. Cell. Physiol. Biochem. 47, 1509–1532.
- Bucher, K., Schmitt, F., Mothes, B., Blumendeller, C., Schäll, D., Piekorz, R., Hirsch, E., Nürnberg, B., Beer-Hammer, S., 2017. Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia. Cell Commun. Signal. 15, 1–1
- Mothes, B.1, Bucher, K.1, Ammon-Treiber, S., Schwab, M., Piekorz, R.P., Hirsch, E., Nürnberg, B., Beer-Hammer, S., 201 P110γ/δ double-deficiency induces eosinophilia and ige production but protects from ova-induced airway inflammation. PLoS One 11, 1–19. ; 1 equal first author
- Tsvetkov D., Shymanets A., Huang Y., Bucher K., Piekorz R., Hirsch E., Beer-Hammer S., Harteneck C., Gollasch M., B. Nürnberg B., 2016. Better Understanding of Phosphoinositide 3-Kinase (PI3K) Pathways in Vasculature: Towards Precision Therapy Targeting Angiogenesis and Tumor Blood Supply. Biochemistry (Moscow) 81, 691-699.
- Carevic, M., Öz, H., Fuchs, K., Laval, J., Schroth, C., Frey, N., Hector, A., Bilich, T., Haug, M., Schmidt, A., Autenrieth, S.E., Bucher, K., Beer-Hammer, S., Gaggar, A., Kneilling, M., Benarafa, C., Gao, J.L., Murphy, P.M., Schwarz, S., Moepps, B., Hartl, D., 2016. CXCR1 Regulates Pulmonary Anti- Pseudomonas Host Defense. J. Innate Immun. 8, 362–373.
- Bucher, K., Schmitt, F., Autenrieth, S.E., Dillmann, I., Nürnberg, B., Schenke-Layland, K., Beer-Hammer, S., 2015. Fluorescent Ly6G antibodies determine macrophage phagocytosis of neutrophils and alter the retrieval of neutrophils in mice. J. Leukoc. Biol. 98, 365–372.
- Schmitt, F., Schäll, D., Bucher, K., Schindler, T.I., Hector, A., Biedermann, T., Zemlin, M., Hartl, D., Beer-Hammer, S., 2015. SLy2 controls the antibody response to pneumococcal vaccine through an IL-5Rα-dependent mechanism in B-1 cells. Eur. J. Immunol. 45, 60–70.
- Shymanets, A., Prajwal, Bucher, K., Beer-Hammer, S., Harteneck, C., Nürnberg, B., 2013. P87 and p101 subunits are distinct regulators determining class I B phosphoinositide 3-kinase (PI3K) specificity. J. Biol. Chem. 288, 31059–31068.
- Bucher, K., Dietz, K., Lackner, P., Pasche, B., Fendel, R., Mordmüller, B., Ben-Smith, A., Hoffmann, W.H., 2011. Schistosoma co-infection protects against brain pathology but does not prevent severe disease and death in a murine model of cerebral malaria. Int. J. Parasitol. 41, 21–31.
- Bahamontes-Rosa N., Bucher K., Held J., Robin A., Hoffmann W. H., Flitsch S. L., Kremsner P. G., Kun J. F., 2009. In vivo anti-malarial effect of the β-amino alcohol 1t on Plasmodiumberghei. Parasitology Research 104, 1459-1464.