Principal Investigator

Ocular Neurodegeneration

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Mathias Seeliger

First nameMathias
Present position and titleProf. Dr. med. Dipl.-Ing.
Group leader Ocular Neurodegeneration Research Group

Business address

Institute for Ophthalmic Research
Centre for Ophthalmology,
University of Tübingen
Elfriede-Aulhorn-Straße 7
72076 Tübingen

Phone: +49 (0)7071 29-80718
Fax: +49 (0)7071 29-4789
E-mail: see[at]

Academic Education

Year Degree University Field of study
2008 Heisenberg-Professur Eberhard-Karls University Tuebingen W3 Ocular Neurodegeneration
2003 Habilitation (PD) Eberhard-Karls University Tuebingen Experimental Ophthalmology
1996 Ph.D. (Dr. med.) Ruhr-University Bochum Medicine
1994 MD Ruhr-University Bochum Medicine
1988 Dipl.-Ing. Ruhr-University Bochum Electrical Engineering
1986/87 (DAAD stipend) Purdue Univ., West Lafayette, IN, USA Electrical Engineering

Professional Experience

Period Institution Position Discipline
2004 Univ. of Missouri, Columbia, MO, USA Visiting Professor Veterinary Ophthalmology
since 2003 University Eye Hospital Tübingen
(now Centre of Ophthalmology)
Group leader (C2) Experimental Ophthalmology
2001-2003 University Eye Hospital Tübingen Group leader (C1) Experimental Ophthalmology
1997-2001 University Eye Hospital Tübingen Research Fellow Ophthalmology
1994-1996 University Eye Hospital Tübingen Resident Ophthalmology

Major Publications

  1. Chen D, Opavsky R, Pacal M, Tanimoto N, Wenzel P, Seeliger MW, Leone G, Bremner R (2007) Rb-mediated neuronal differentiation through cell cycle independent regulation of E2f3a. PLoS Biol 5: E179-1:16.
  2. Tolmachova T, Anders R, Abrink M, Bugeon L, Dallman MJ, Futter CE, Ramalho JS, Tonagel F, Tanimoto N, Seeliger MW, Huxley C, Seabra MC (2006) Cell-autonomous retinal degeneration in a conditional knock-out mouse model of choroideremia. J Clin Invest  116, 386-394.
  3. Grimm C, Wenzel A, Groszer M, Mayser H, Seeliger MW, Bauer C, Gassmann M, Reme CE (2002) HIF-1–induced erythropoietin in the hypoxic retina protects against light–induced retinal degeneration. Nat Med 8: 718-724.
  4. Seeliger MW, Grimm C, Ståhlberg F, Friedburg C, Jaissle G, Zrenner E, Guo H, Remé ChE, Humphries P, Hofmann F, Biel M, Fariss RN, Redmond TM, Wenzel A (2001). New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis. Nat Genet 29: 70-74.
  5. Biel M, Seeliger MW, Pfeifer A, Kohler K, Gerstner A, Ludwig A, Jaissle G, Fauser S, Zrenner E, Hofmann F (1999). Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3. Proc Natl Acad Sci USA 96: 7553-7557.