Nitric oxide modulates contrast suppression in a subset of mouse retinal ganglion cells
The results in a publication of an important scientific collaboration between the IOR in Tübingen and the IdV in Paris.
This publication in eLife presents the results of a scientific collaboration between the IOR in Tübingen and the IdV in Paris.
This work gives the first detailed analysis of the modulatory effects of nitric oxide (NO) on retinal ganglion cells (RGCs), providing valuable insights for visual neuroscience and highlighting the complexity of retinal processing.
Neuromodulators play a crucial role in the regulation of neuronal circuits across the nervous system. Nitric oxide (NO) is an important neuromodulator, particularly in the retina, where it influences light adaptation, gain control and gap junctional coupling. However, its effect on retinal ganglion cells (RGCs), which transmit visual signals to the brain, remains unclear.
In this study, researchers from these two renowned vision research institutes used advanced techniques - two-photon calcium imaging and multi-electrode array (MEA) recordings - to investigate how nitric oxide (NO) affects light-evoked activity in RGCs of the mouse retina.
Here is the link to the original publication: “Nitric oxide modulates contrast suppression in a subset of mouse retinal ganglion cells”
Dominic Gonschorek, Matías A Goldin, Jonathan Oesterle, Tom Schwerd-Kleine, Ryan Arlinghaus, Zhijian Zhao, Timm Schubert, Olivier Marre, Thomas Euler
