Ueffing Lab

Molecular Biology of Retinal Degenerations

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Angela Armento

Surname Armento
First name Angela
Nationality Italian
Present position and title

Postdoc, Dr. rer. nat

Business address

Institute for Ophthalmic Research
University of Tübingen
Elfriede-Aulhorn-Strasse 7
D-72076 Tübingen,

Phone: +49 (0)7071 29-84953
Fax: +49 (0)7071 29-5777
E-mail: angela.armento@uni-tuebingen.de

Academic Education

Year Degree University Field of study



University of Tuebingen

Cellular and Molecular Neuroscience


Master degree

University of Parma

Medical, Pharmaceutical and Veterinary Biotechnologies


Bachelor degree

University of Parma


Professional Experience

Period Institution Position Discipline



University of Tuebingen, Institute for Ophthalmic research

Complement system in age-related macular degeneration



University of Tuebingen, Institute for Ophthalmic research

Understing molecular drivers of Age-related macular degeneration



University of Tuebingen, Hertie Institute for Clinical Brain Research

The role of carboxypeptidase E in the “go or grow” hypothesis in glioblastoma”



Erasmus Placement Scholarship: Training in Children Hospital, University of Tuebingen

Travel Grants


Retinal Degeneration (RD) meeting and BrightFocus Fast track workshop Travel Award


Prize for young scientist (travel) award 7th Mildred Scheel Cancer Conference

Funded Grants


Fortüne Junior Antrag nr. 2640-0-0. Impact of Complement Factor H Y402H polymorphism on RPE cells and AMD pathology.

Selected Publications

  1. Merle DA, Provenzano F, Jarboui MA, Kilger E, Clark SJ, Deleidi M, Armento A.* and Ueffing M.. mTOR inhibition via Rapamycin treatment partially reverts the deficit in energy metabolism caused by FH loss in RPE cells. Antioxidants. 2021. *co-last author

  2. Armento A, Murali A, Marzi J, Arango-Gonzalez B, Kilger E, Clark SJ, et al. FH loss in RPE cells causes retinal degeneration in a human RPE-porcine retinal explant co-culture model. Biomolecules. 2021;11(11):1621.

  3. Armento A, Schmidt TL, Sonntag I, Merle D, Jarboui MA, Kilger E, et al. CFH loss in human RPE cells leads to inflammation and complement system dysregulation via the NF-κB pathway. IJMS 2021.

  4. Armento A, Ueffing M, Clark SJ. The complement system in age-related macular degeneration. Cell Mol Life Sci. 2021;78(10):4487-505.

  5. Samardzija M, Corna A, Gomez-Sintes R, Jarboui MA, Armento A, Roger JE, et al. HDAC inhibition ameliorates cone survival in retinitis pigmentosa mice. Cell Death Differ. 2021;28(4):1317-32.

  6. Armento A, Honisch S, Panagiotakopoulou V, Sonntag I, Jacob A, Bolz S, et al. Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells. Sci Rep. 2020;10(1):10320.

  7. Armento A, Ehlers J, Schotterl S, Naumann U. Molecular Mechanisms of Glioma Cell Motility. In: De Vleeschouwer S, editor. Glioblastoma. Brisbane (AU)2017.

  8. Armento A, Ilina EI, Kaoma T, Muller A, Vallar L, Niclou SP, et al. Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors. Int J Oncol. 2017;51(2):702-14.

  9. Ilina EI, Armento A, Sanchez LG, Reichlmeir M, Braun Y, Penski C, et al. Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux. Oncotarget. 2017;8(40):67567-91.

  10. Chiu M, Tardito S, Pillozzi S, Arcangeli A, Armento A, Uggeri J, et al. Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts. Br J Cancer. 2014;111(6):1159-67.