Ueffing Lab

Molecular Biology of Retinal Degenerations

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Cell Death Mechanisms

Comparative analysis of cell death associated enzymatic activities in ten different models for retinal degeneration.

A very interesting aspect of our research is that most of the biochemical processes we found to be involved in photoreceptor neurodegeneration are not normally associated with established cell death mechanisms such as apoptosis or necrosis. We believe that we may instead be facing a novel form of cell death that could be highly relevant not only for photoreceptors but also for many other types of neurodegenerative diseases. The retina could provide us with unique possibilities to study and further elucidate such a novel cell death mechanism.

Related Publications

  1. Sahaboglu A, Paquet-Durand O, Dietter J, Dengler K, Bernhard-Kurz S, Ekström P, Hitzmann B, Ueffing M, Paquet-Durand F: Retinitis Pigmentosa: Rapid neurodegeneration is governed by slow cell death mechanisms. Cell Death Dis. 4, e488, 2013.
  2. Wei T, Schubert T*, Paquet-Durand F*, Tanimoto N, Chang L, Koeppen K, Ott T, Griesbeck O, Seeliger M, Euler T, Wissinger B: Light driven calcium signals in mouse cone photoreceptors. J Neurosci, 32: 6981-94, 2012.
  3. Trifunović D, Sahaboglu A, Kaur J, Mencl S, Zrenner E, Ueffing M, Arango-Gonzalez B, Paquet-Durand F: Neuroprotective Strategies for the Treatment of Inherited Photoreceptor Degeneration. Curr Mol Med, 12: 598-612, 2012.
  4. Jaumann M, Dettling J, Gubelt M, Zimmermann U, Gerling A, Paquet-Durand F, Feil S, Wolpert S, Franz C, Varakina K, Xiong H, Brandt N, Kuhn S, Geisler HS, Rohbock K, Ruth P, Schlossmann J, Hütter J, Sandner P, Feil R, Engel J, Knipper M, Rüttiger L: cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. Nat Med, 18:252-9, 2012.
  5. Paquet-Durand F, Beck S, Michalakis S, Goldmann T, Huber G, Mühlfriedel R, Trifunovic D, Fischer MD, Fahl E, Duetsch G, Becirovic E, Wolfrum U, van Veen T, Biel M, Tanimoto N, Seeliger MW: A key role for cyclic–nucleotide gated (CNG) channels in cGMP-related Retinitis Pigmentosa. Hum Mol Gen, 20:941-7, 2011.
  6. Sancho-Pelluz J, Alavi MV, Sahaboglu A, Kustermann S, Farinelli P, Azadi S, van Veen T, Romero FJ, Paquet-Durand F, Ekström P: Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse. Cell Death Dis, 1: e24, 2010.
  7. Trifunović D, Dengler K, Michalakis S, Zrenner E, Wissinger B, Paquet-Durand F: cGMP-dependent cone photoreceptor degeneration in the cpfl1 mouse retina. J Comp Neurol, 518:3604-17, 2010.
  8. Michalakis S, Mühlfriedel R, Tanimoto N, Krishnamoorthy V, Koch S, Fischer MD, Becirovic E, Bai L, Huber G, Beck SC, Fahl E, Büning H, Paquet-Durand F, Zong X, Gollisch T, Biel M, Seeliger MW: Restoration of Cone Vision in the CNGA3−/− Mouse Model of Congenital Complete Lack of Cone Photoreceptor Function. Mol Ther, 18:2057-63, 2010.
  9. Paquet-Durand F, Sanges D, McCall J, Silva J, van Veen T, Marigo V, Ekström P: Photoreceptor rescue and toxicity induced by different calpain inhibitors. J Neurochem, 115:930-40, 2010.
  10. Sahaboglu A, Tanimoto N, Kaur J, Sancho-Pelluz J, Huber G, Fahl E, Arango-Gonzalez B, Zrenner E, Ekström P, Löwenheim H, Seeliger MW, Paquet-Durand F: PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function. PLoS One, 5:e15495, 2010.