Over the years the Clark lab has generated a series of publicly (scientific)-available resources to help others advance their research. These include:

The Helmut Ecker Eye Tissue Resource (HEETR)

Founded in 2015 by Prof. Simon Clark and Prof. Paul Bishop, the HEETR contains frozen, unfixed, eye tissues from >1200 genotyped and phenotyped human donors. See - https://www.eye-tuebingen.de/facilities/eye-tissue-resource

Transcriptome and genome datasets for retinal gene expression

This includes 1,483,595 significant cis-expression quantitative trait loci (eQTLs) impacting 9,959 and 3,699 genes in Neurosensory retina (NSR) and the retinal pigment epithelium (RPE), respectively. This study increases understanding of gene expression regulation in the human retina and is available through the European Genome-Phenome Archive (EGA) https://ega-archive.org/studies/EGAS50000001443

Translational resources

The lab’s translational portfolio includes the development of novel complement modifiers that can be used as therapeutics in complement-mediated diseases of the eye, as well as around the body. We also help develop new diagnostic tools for complement driven disease and methods for patient stratification for future treatment.

Recently, our translational work has focused on the delivery of suitable complement modifiers to the human eye. These therapeutics have been specifically designed to function in the eye’s unique environment and architecture, and a spin-out company - Complement Therapeutics - has been formed to facilitate the transition of this work into the clinic and patients suffering AMD.