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Forschungsinstitut fuer AugenheilkundeForschungsinstitut fuer AugenheilkundeForschungsinstitut fuer Augenheilkunde
Forschungsinstitut fuer Augenheilkunde
INSTITUTE FOR OPHTHALMIC RESEARCH
FORSCHUNGSINSTITUT FÜR AUGENHEILKUNDE

Tina Beyer

Research fellow, Dr. rer. nat.
 

Business address

Molecular Biology of Retinal Degenerations
Institute for Ophthalmic Research
University of Tübingen
Elfriede-Aulhorn-Strasse 7
D-72076 Tübingen,
Germany

Phone: +49 (0)7071 29-84955
Fax: +49 (0)7071 29-5777
E-mail: tina.beyer@uni-tuebingen.de

Academic Education

2011Dr. rer.nat, Embryology, University of Hohenheim, Stuttgart
2006Diploma, Biology, University of Hohenheim, Stuttgart

Professional Experience

03/2014–presentPostdoc, Ciliogenesis, Medical Proteome Center, Institute for Ophthalmic Research, University of Tuebingen
05/2013–02/2014Postdoc, CVB3 - induced cardiomyopathy, Sports Medicine, Medical Clinic, University of Tuebingen
05/2011–04/2013Sales representative, Lab equipment, Peqlab Biotechnology GmbH

Past and Current Funding

2022–2025DFG Einzelprojekt: Analysis of the molecular function of ALMS1
07/2021–06/2022fortüne programme – Faculty of Medicine, University of Tuebingen
09/2016–08/2018fortüne programme – Faculty of Medicine, University of Tuebingen
01/2007–12/2008LGF BW, scholarship

Memberships and Functions in Scientific Societies

  • German Society for Proteome Research
  • Junior Academy Tübingen

Selected Publications

  1. Beyer T, Diwan GD, Leonhard T, Dahlke K, Klose F, Stehle IF, Seda M, Bolz S, Woerz F, Russell RB, Jenkins D, Ueffing M, Boldt K. Ciliopathy-Associated Missense Mutations in IFT140 are Tolerated by the Inherent Resilience of the IFT Machinery. Mol Cell Proteomics. 2025 Mar;24(3):100916. doi: 10.1016/j.mcpro.2025.100916. Epub 2025 Jan 27. PMID: 39880085; PMCID: PMC11907452.
  2. Woerz F, Hoffmann F, Antony S, Bolz S, Jarboui MA, Junger K, Klose F, Stehle IF, Boldt K, Ueffing M, Beyer T. Interactome Analysis Reveals a Link of the Novel ALMS1-CEP70 Complex to Centrosomal Clusters. Mol Cell Proteomics. 2024 Jan;23(1):100701. doi: 10.1016/j.mcpro.2023.100701. Epub 2023 Dec 18. PMID: 38122899; PMCID: PMC10820798.
  3. Hoffmann, F., Bolz, S., Junger, K., Klose, F., Stehle, I.F., Ueffing, M., Boldt, K., and Beyer, T. (2023). Paralog-specific TTC30 regulation of Sonic hedgehog signaling. Front. Mol. Biosci. 10, 1268722. 10.3389/fmolb.2023.1268722.
  4. Stehle, I.F., Imventarza, J.A., Woerz, F., Hoffmann, F., Boldt, K., Beyer, T., Quinn, P.M., and Ueffing, M. (2024). Human CRB1 and CRB2 form homo- and heteromeric protein complexes in the retina. Life Sci. alliance 7. 10.26508/lsa.202302440.
  5. Beyer, T., Martins, T., Srikaran, J.J., Seda, M., Peskett, E., Klose, F., Junger, K., Beales, P.L., Ueffing, M., Boldt, K., et al. (2024). Affinity Purification of Intraflagellar Transport (IFT) Proteins in Mice Using  Endogenous Streptavidin/FLAG Tags. Methods Mol. Biol. 2725, 199–212. 10.1007/978-1-0716-3507-0_12.
  6. Aslanyan, M.G., Doornbos, C., Diwan, G.D., Anvarian, Z., Beyer, T., Junger, K., van Beersum, S.E.C., Russell, R.B., Ueffing, M., Ludwig, A., et al. (2023). A targeted multi-proteomics approach generates a blueprint of the ciliary ubiquitinome. Front. cell Dev. Biol. 11, 1113656. 10.3389/fcell.2023.1113656.
  7. Hoffmann, F., Bolz, S., Junger, K., Klose, F., Schubert, T., Woerz, F., Boldt, K., Ueffing, M., and Beyer, T. (2022). TTC30A and TTC30B Redundancy Protects IFT Complex B Integrity and Its Pivotal  Role in Ciliogenesis. Genes (Basel). 13. 10.3390/genes13071191.
  8. Beyer et al.; ‘Tissue- and isoform-specific protein complex analysis with natively processed bait proteins.’ J Proteomics (2021)
  9. Beyer T, Bolz S, Junger K, Horn N, Moniruzzaman M, Wissinger Y, Ueffing M, Boldt K. CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement. Mol Cell Proteomics. 2018 Jul;17(7):1285-1294. doi: 10.1074/mcp.RA117.000487. Epub 2018 Apr 3.
  10. May-Simera HL, Gumerson JD, Gao C, Campos M, Cologna SM, Beyer T, Boldt K, Kaya KD, Patel N, Kretschmer F, Kelley MW, Petralia RS, Davey MG, Li T. Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina. Cell Rep. 2016 Oct 25;17(5):1399-1413. doi: 10.1016/j.celrep.2016.09.089.
  11. Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R; UK10K Rare Diseases Group. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016 May 13;7:11491. doi: 10.1038/ncomms11491
  12. Beyer T, Thumberger T, Schweickert A, Blum M. Connexin26-mediated transfer of laterality cues in Xenopus. Biol Open. 2012 May 15;1(5):473-81. doi: 10.1242/bio.2012760. Epub 2012 Mar 30.
  13. Beyer T*, Danilchik M*, Thumberger T*, Vick P*, Tisler M, Schneider I, Bogusch S, Andre P, Ulmer B, Walentek P, Niesler B, Blum M, Schweickert A. Serotonin signaling is required for Wnt-dependent GRP specification and leftward flow in Xenopus.  Curr Biol. 2012 Jan 10;22(1):33-9. doi: 10.1016/j.cub.2011.11.027. Epub 2011 Dec 15. * equal authors